Collagen fibril diameters in the healing adult rabbit medial collateral ligament
Abstract
This study was carried out to test the hypothesis that improvements in ligament scar mechanical behavior during healing may be related, in part, to increases in collagen fibril diameters. Forty-eight adult female New Zealand White rabbits had standardized midsubstance gap injuries created in their right medial collateral ligaments (MCLs) and were allowed normal cage activity until sacrifice in groups of 12 at 3, 6, 14 or 40 weeks post-injury. Eight animals in each group had both MCLs tested biomechanically while 4 animals had transmission EM investigation of midsubstance collagen fibril diameters by a standardized protocol. Results of mechanical tests showed a three- to fourfold increase in scar strength and stiffness over the intervals of healing studied while there was no change in collagen mean fibril minimum diameters. These results demonstrate no correlation between material or structural properties of scar and collagen fibril diameters in this model of healing and suggest that other mechanisms for scar mechanical improvement under these conditions must be investigated.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
As ligament laxity persists, the affected joint and other structures in and around the knee joint are exposed to the risk of further damage.
“As ligament laxity persists, the affected joint and other structures in and around the knee joint are exposed to the risk of further damage [44,45].”
From Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint (2023) · cites this paper as [44]
Cites
Medial collateral ligament healing: A multidisciplinary assessment in rabbits
Frank, C., Woo, S. L.-Y., Amiel, D., Harwood, F., Gomez, M., & Akeson, W. (1983) · The American Journal of Sports Medicine · doi:10.1177/036354658301100602 · Cited by 367 · see citing works
Self-citationCollagen in Dermal Wound Repair
McPherson, J. M., & Piez, K. A. (1988) · The Molecular and Cellular Biology of Wound Repair · doi:10.1007/978-1-4615-1795-5_20 · Cited by 39 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Collagen Fibril Diameters in the Rabbit Medial Collateral Ligament Scar: A Longer Term Assessment
Frank, C., McDonald, D., & Shrive, N. (1997) · Connective Tissue Research · doi:10.3109/03008209709160226 · Cited by 115 · see citing works
Self-citationEarly medial collateral ligament scars have inferior creep behaviour
Thornton, G. M., Leask, G. P., Shrive, N. G., & Frank, C. B. (2000) · Journal of Orthopaedic Research · doi:10.1002/jor.1100180211 · Cited by 76 · see citing works
Self-citationPrimed Mesenchymal Stem Cells Alter and Improve Rat Medial Collateral Ligament Healing
Saether, E. E., Chamberlain, C. S., Aktas, E., Leiferman, E. M., Brickson, S. L., & Vanderby, R. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-015-9633-5 · Cited by 34 · see citing works
Basic Science of Ligament Healing: Medial Collateral Ligament Healing With and Without Treatment
Creighton, R. A., Spang, J. T., & Dahners, L. E. (2005) · Sports Medicine and Arthroscopy Review · doi:10.1097/01.jsa.0000173623.62717.03 · Cited by 25 · see citing works
Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint
Lee, C.-S., Jeon, O.-H., Han, S.-B., & Jang, K.-M. (2023) · Medicina · doi:10.3390/medicina59040725 · Cited by 7 · see citing works
“the affected joint and other structures in and around the knee joint are exposed to the risk of further damage [44,45].”
Background
- Authors
- Frank, C., McDonald, D., Bray, D., Bray, R., Rangayyan, R., Chimich, D., & Shrive, N.
- Affiliations
- University of Calgary (CA)
- University of Lethbridge (CA)
- Venue
- Connective Tissue Research
- Publisher
- Informa UK Limited
- Published
- 1992-01
- Volume
- 27
- Issue
- 4
- Pages
- 251-263
- ISSN
- 0300-8207 (ISSN-L)
- 1607-8438
- OpenAlex
- W2077460977
- Cited by
- 123
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 6 · 2012: 5
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Connective Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Arthritis Society
- Medical Research Council
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- collagen fibril diameter, ligament healing, medial collateral ligament, rabbit model, transmission electron microscopy, ligament biomechanics
- MeSH terms
- Animals, Biomechanical Phenomena, Cicatrix, Collagen, Female, Kinetics, Ligaments, Articular, Microscopy, Electron, Rabbits, Wound Healing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
