Cited by 113Dementia and Cognitive Impairment ResearchPharmaceutical Practices and Patient OutcomesSchizophrenia research and treatment

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Antipsychotic Use in Dementia: Is There a Problem and Are There Solutions?

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Kirkham, Julia, Sherman, Chelsea, Velkers, Clive, Maxwell, Colleen, Gill, Sudeep, Rochon, Paula, Seitz, Dallas·2017·The Canadian Journal of Psychiatry

DOI 10.1177/0706743716673321PMC PMC5317021

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Abstract

Antipsychotics are necessary for many older adults to treat major mental illnesses or reduce distressing psychiatric symptoms. Current controversy exists over the role of antipsychotics in the management of neuropsychiatric symptoms (NPS) in persons with dementia. Although some NPS may be appropriately and safely treated with antipsychotics, a fine balance must be achieved between the benefits of these medications, which are often modest, and adverse events, which may have significant consequences. Approximately one-third of all persons with dementia are currently prescribed antipsychotic medications, and there is significant variation in the use of antipsychotics across care settings and providers. Reducing the inappropriate or unnecessary use of antipsychotics among persons with dementia has been the focus of increasing attention owing to better awareness of the potential problems associated with these medications. Several approaches can be used to curb the use of antipsychotics among persons with dementia, including policy or regulatory changes, public reporting, and educational outreach. Recently, there has been encouraging evidence of a downward trend in the use of antipsychotics in many long-term care settings, although prescribing rates are still higher than what is likely optimal. Although reducing the inappropriate use of antipsychotics is a complex task, psychiatrists can play an important role via the provision of clinical care and research evidence, contributing to improved care of persons with dementia in Canada and elsewhere.

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Authors: Kirkham, J., Sherman, C., Velkers, C., Maxwell, C., Gill, S., Rochon, P., & Seitz, D.
Affiliations: Queen's University (CA)
University of Waterloo (CA)
Women's College Hospital (CA)
Corresponding author: Seitz, Dallas
ORCID: Kirkham, Julia
Maxwell, Colleen
Gill, Sudeep
Rochon, Paula
Seitz, Dallas
Venue: The Canadian Journal of Psychiatry
Publisher: SAGE Publications
Published: 2016-10-08
Volume: 62
Issue: 3
Pages: 170-181
ISSN: 0706-7437 (ISSN-L)
1497-0015
DOI: 10.1177/0706743716673321
PMC: PMC5317021
OpenAlex: W2529748942
Cited by: 113
References: 100
Citations by year: 2026: 6 · 2025: 13 · 2024: 10 · 2023: 14 · 2022: 19 · 2021: 18 · 2020: 14 · 2019: 14 · 2018: 3 · 2017: 2
FWCI: 5.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: The Canadian Journal of Psychiatry (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Consortium canadien en neurodégénérescence associée au vieillissement
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: antipsychotic drugs, dementia, neuropsychiatric symptoms, inappropriate prescribing, prescribing variation, long-term care, adverse drug reactions, prescribing policy, public reporting, clinician education, role of psychiatrists
MeSH terms: Dementia, Humans, Drug Prescriptions, Antipsychotic Agents

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Antipsychotic Use in Dementia: Is There a Problem and Are There Solutions?

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