The DOI matches its Crossref record; 116 of the 118 references it cites were found in a registry or an index.
Guidelines for the Pharmacotherapy of Schizophrenia in Adults
Open accessAbstract
Objective: The present guidelines address the pharmacotherapy of schizophrenia in adults across different stages, phases, and symptom domains. Method: Guidelines were developed using the ADAPTE process, which takes advantage of existing guidelines. Six guidelines were identified for adaptation, with recommendations extracted from each. For those specific to the pharmacotherapy of schizophrenia in adults, a working group selected between guidelines and recommendations to create an adapted guideline. Results: Recommendations can be categorized into 6 areas that include 1) first-episode schizophrenia, 2) acute exacerbation, 3) relapse prevention and maintenance treatment, 4) treatment-resistant schizophrenia, 5) clozapine-resistant schizophrenia, and 6) specific symptom domains. For each category, recommendations are made based on the available evidence, which is discussed and linked to other established guidelines. Conclusions: In most cases, evidence-based recommendations are made that can be used to guide current clinical treatment and decision making. Notably, however, there is a paucity of established evidence to guide treatment decision making in the case of clozapine-resistant schizophrenia, a subsample that represents a sizable proportion of those with schizophrenia.
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“yet recommendations on their use in the clinical routine care differ from one guideline to another, and their current use is still limited despite their proved efficacy on long-term patient management [26].”
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Self-citation
Metadata
- Authors
- Remington, G., Addington, D., Honer, W., Ismail, Z., Raedler, T., & Teehan, M.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- University of Calgary (CA)
- University of British Columbia (CA)
- Dalhousie University (CA)
- Corresponding author
- Remington, Gary
- Venue
- The Canadian Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2017-07-13
- Volume
- 62
- Issue
- 9
- Pages
- 604-616
- ISSN
- 0706-7437 (ISSN-L)
- 1497-0015
- PMC
- PMC5593252
- OpenAlex
- W2737472140
- Cited by
- 332
- References
- 118
- Citations by year
- 2026: 29 · 2025: 32 · 2024: 46 · 2023: 38 · 2022: 66 · 2021: 56 · 2020: 23 · 2019: 28 · 2018: 13 · 2017: 1
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Canadian Journal of Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hotchkiss Brain Institute, University of Calgary
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, pharmacotherapy, adults, first-episode schizophrenia, acute exacerbation, relapse prevention, maintenance therapy, treatment-resistant schizophrenia, clozapine-resistant schizophrenia, antipsychotic drugs, symptom domains, evidence-based recommendations
- MeSH terms
- Adult, Canada, Humans, Schizophrenia, Antipsychotic Agents, Practice Guidelines as Topic, Evidence-Based Medicine
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