The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Dim Nighttime Light Impairs Cognition and Provokes Depressive-Like Responses in a Diurnal Rodent
Open accessAbstract
Circadian disruption is a common by-product of modern life. Although jet lag and shift work are well-documented challenges to circadian organization, many more subtle environmental changes cause circadian disruption. For example, frequent fluctuations in the timing of the sleep/wake schedule, as well as exposure to nighttime lighting, likely affect the circadian system. Most studies of these effects have focused on nocturnal rodents, which are very different from diurnal species with respect to their patterns of light exposure and the effects that light can have on their activity. Thus, the authors investigated the effect of nighttime light on behavior and the brain of a diurnal rodent, the Nile grass rat. Following 3 weeks of exposure to standard light/dark (LD; 14:10 light [~150 lux] /dark [0 lux]) or dim light at night (dLAN; 14:10 light [~150 lux] /dim [5 lux]), rats underwent behavioral testing, and hippocampal neurons within CA1, CA3, and the dentate gyrus (DG) were examined. Three behavioral effects of dLAN were observed: (1) decreased preference for a sucrose solution, (2) increased latency to float in a forced swim test, and (3) impaired learning and memory in the Barnes maze. Light at night also reduced dendritic length in DG and basilar CA1 dendrites. Dendritic length in the DG positively correlated with sucrose consumption in the sucrose anhedonia task. Nighttime light exposure did not disrupt the pattern of circadian locomotor activity, and all grass rats maintained a diurnal activity pattern. Together, these data suggest that exposure to dLAN can alter affective responses and impair cognition in a diurnal animal.
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In the citing paper
“Studies of light at night exposure in diurnal rodent species generally yield similar affective responses to nocturnal rodents57,58.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [58]
In the citing paper
“Additionally, diurnal rats exposed to dim light at night (5 lux) for 3 weeks demonstrated increased depressive-like behavior and reduced dendritic length within CA1 and dentate gyrus58.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [58]
In the citing paper
“As with constant light, exposure to dim light at night induces depressive-like behavior in multiple species of rodents58–60,95.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [58]
In the citing paper
“There is substantial literature showing that environmental noise228,229 and light230–233 can adversely impact sleep and that neighborhoods that are active at night may directly impact sleep through these.”
From Sleep, Health, and Society (2017) · cites this paper as [230]
In the citing paper
“There is substantial literature showing that environmental noise228,229 and light230–233 can adversely impact sleep and that neighborhoods that are active at night may directly impact sleep through these.”
From Sleep, Health, and Society (2017) · cites this paper as [230]
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Cited by
Sorted by citations
Circadian rhythm disruption and mental health
Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030
Self-citationLight as a central modulator of circadian rhythms, sleep and affect
LeGates, T. A., Fernandez, D. C., & Hattar, S. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3743 · Cited by 1,001
Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738
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The Effects of Light at Night on Circadian Clocks and Metabolism
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Self-citation
Metadata
- Authors
- Fonken, L. K., Kitsmiller, E., Smale, L., & Nelson, R. J.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- Michigan State University (US)
- Corresponding author
- Fonken, Laura K.
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 2012-08
- Volume
- 27
- Issue
- 4
- Pages
- 319-327
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W2160296060
- Cited by
- 203
- References
- 40
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 16 · 2023: 11 · 2022: 20 · 2021: 14 · 2020: 15 · 2019: 11 · 2018: 16 · 2017: 19 · 2016: 11 · 2015: 11 · 2014: 13 · 2013: 16
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biological Rhythms (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- American Heart Association
- United States - Israel Binational Science Foundation
- United States-Israel Binational Science Foundation
- Israel Science Foundation
- Division of Integrative Organismal Systems
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- dim light at night, circadian rhythm disruption, diurnal rodents, Nile grass rat, cognitive impairment, depression-like behavior, hippocampus, learning and memory, forced swim test, circadian locomotor activity, artificial light at night
- MeSH terms
- Analysis of Variance, Animals, Circadian Rhythm, Cognition, Corticosterone, Dendrites, Depressive Disorder, Food Preferences, Light, Male, Motor Activity, Neurons, Swimming, Photoperiod, Maze Learning, Dentate Gyrus, Murinae, CA1 Region, Hippocampal, CA3 Region, Hippocampal
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