The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Circadian Clocks in the Immune System
Open accessAbstract
The immune system is a complex set of physiological mechanisms whose general aim is to defend the organism against non-self-bodies, such as pathogens (bacteria, viruses, parasites), as well as cancer cells. Circadian rhythms are endogenous 24-h variations found in virtually all physiological processes. These circadian rhythms are generated by circadian clocks, located in most cell types, including cells of the immune system. This review presents an overview of the clocks in the immune system and of the circadian regulation of the function of immune cells. Most immune cells express circadian clock genes and present a wide array of genes expressed with a 24-h rhythm. This has profound impacts on cellular functions, including a daily rhythm in the synthesis and release of cytokines, chemokines and cytolytic factors, the daily gating of the response occurring through pattern recognition receptors, circadian rhythms of cellular functions such as phagocytosis, migration to inflamed or infected tissue, cytolytic activity, and proliferative response to antigens. Consequently, alterations of circadian rhythms (e.g., clock gene mutation in mice or environmental disruption similar to shift work) lead to disturbed immune responses. We discuss the implications of these data for human health and the areas that future research should aim to address.
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Cites
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“For example, macrophages stimulated with LPS at different times after synchronization of their clocks in vitro will show a rhythm of secretion of tumor necrosis factor α (TNFα) (Keller et al., 2009).”
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The mPer2 gene encodes a functional component of the mammalian circadian clock
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Circadian Clock Proteins and Immunity
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Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6C hi Inflammatory Monocytes
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Cited by
Molecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
The Circadian Clock and Human Health
Roenneberg, T., & Merrow, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.011 · Cited by 1,004
Circadian control of brain glymphatic and lymphatic fluid flow
Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, F. F., Metcalfe, T., Nguyen, R., Benrais, A., & Nedergaard, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18115-2 · Cited by 704
Circadian disruption and human health
Fishbein, A. B., Knutson, K. L., & Zee, P. C. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148286 · Cited by 468
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216
“Finally, there is increasing awareness of the effects of the cellular circadian clock and diet on cellular metabolism driving immune responses [195, 307, 308], with differences in housing conditions and significant variability in macronutrient composition of ad libitum ‘standard’ chow between institutions.”
Background
Metadata
- Authors
- Labrecque, N., & Cermakian, N.
- Venue
- Journal of Biological Rhythms
- Publisher
- SAGE Publications
- Published
- 2015-04-20
- Volume
- 30
- Issue
- 4
- Pages
- 277-290
- ISSN
- 0748-7304 (ISSN-L)
- 1552-4531
- OpenAlex
- W2109338856
- Cited by
- 466
- References
- 68
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- green
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