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Cited by 279Diet and metabolism studiesAutism Spectrum Disorder ResearchChild Nutrition and Feeding Issues

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

Application of a Ketogenic Diet in Children With Autistic Behavior: Pilot Study

Evangeliou, Athanasios, Vlachonikolis, Ioannis, Mihailidou, Helen, Spilioti, Martha, Skarpalezou, Astrinia, Makaronas, Nikolaos, Prokopiou, Ahilleas, Christodoulou, Panagiotis, Liapi-Adamidou, Georgia, Helidonis, Emmanouel, Sbyrakis, Stylianos, Smeitink, Jan·2003·Journal of Child Neurology
DOI 10.1177/08830738030180020501
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Abstract

A pilot prospective follow-up study of the role of the ketogenic diet was carried out on 30 children, aged between 4 and 10 years, with autistic behavior. The diet was applied for 6 months, with continuous administration for 4 weeks, interrupted by 2-week diet-free intervals. Seven patients could not tolerate the diet, whereas five other patients adhered to the diet for 1 to 2 months and then discontinued it. Of the remaining group who adhered to the diet, 18 of 30 children (60%), improvement was recorded in several parameters and in accordance with the Childhood Autism Rating Scale. Significant improvement (> 12 units of the Childhood Autism Rating Scale) was recorded in two patients (pre-Scale: 35.00 +/- 1.41[mean +/- SD]), average improvement (> 8-12 units) in eight patients (pre-Scale: 41.88 +/- 3.14[mean +/- SD]), and minor improvement (2-8 units) in eight patients (pre-Scale: 45.25 +/- 2.76 [mean +/- SD]). Although these data are very preliminary, there is some evidence that the ketogenic diet may be used in autistic behavior as an additional or alternative therapy.

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Research works printed but not linked: 7

  1. Wilder RM, 1921, Mayo Clin Proc, 2, 307
  2. Bujas-Petkovic Z., 1989, Lijek Vjesn, 111, 458
  3. Eaton I.: Epilepsy, in Thomas B (ed): Manual of Dietetic Practice. Oxford, Blackwell Science Ltd, 1988, 489—497.
  4. Reichelt KL, 1991, Tidsskr Nor Laegeforen, 111, 1286
  5. 10.1023/A:1025861522935 · DOI
  6. Eaton J.: Ketogenic diet for epilepsy, in Shaw V, Lawson M (eds): Clinical Paediatric Dietetics . Oxford, Blackwell Science Ltd , 1994,168-174.
  7. Wing RR, 1995, Int J Obes Relat Metab Disord, 19, 811

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Metadata

Authors
Evangeliou, A., Vlachonikolis, I., Mihailidou, H., Spilioti, M., Skarpalezou, A., Makaronas, N., Prokopiou, A., Christodoulou, P., Liapi-Adamidou, G., Helidonis, E., Sbyrakis, S., & Smeitink, J.
Affiliations
  • University of Crete (GR)
  • Children's Hospital Agia Sophia (GR)
  • Center of Mental Health, Heraklion, Crete, Greece
  • Center of Mental Health, Chania, Crete, Greece
  • National and Kapodistrian University of Athens (GR)
  • Department of Pediatrics, University Hospital Nijmegen, Nijmegen, The Netherlands
Corresponding author
Evangeliou, Athanasios
ORCID
Venue
Journal of Child Neurology
Publisher
SAGE Publications
Published
2003-02
Volume
18
Issue
2
Pages
113-118
ISSN
  • 0883-0738 (ISSN-L)
  • 1708-8283
DOI
10.1177/08830738030180020501
OpenAlex
W1966556786
Cited by
279
References
28
Citations by year
2026: 6 · 2025: 13 · 2024: 19 · 2023: 20 · 2022: 34 · 2021: 22 · 2020: 25 · 2019: 10 · 2018: 17 · 2017: 17 · 2016: 14 · 2015: 10 · 2014: 11 · 2013: 13 · 2012: 5
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Child Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords
ketogenic diet, autism spectrum disorder, autistic behavior, dietary therapy, Childhood Autism Rating Scale, dietary adherence, children, complementary and alternative medicine
MeSH terms
Autistic Disorder, Child, Child, Preschool, Dietary Carbohydrates, Dietary Proteins, Female, Humans, Ketone Bodies, Male, Pilot Projects, Severity of Illness Index, Treatment Outcome

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