Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging
Abstract
OBJECTIVE: Cytoarchitectonic changes in the anterior cingulate cortex, hippocampus, subiculum, entorhinal cortex, amygdala, mammillary bodies, and septum were reported in a postmortem study of autism. Previously, the authors found smaller cingulate volume and decreased metabolism of the cingulate in seven autistic patients. In this study, they measured the volume and glucose metabolism of the amygdala, hippocampus, and cingulate gyrus in an expanded group of 17 patients with autism spectrum disorders (autism [N=10] or Asperger's disorder [N=7]) and 17 age- and sex-matched healthy volunteers. METHOD: Subjects performed a serial verbal learning test during (18)F-deoxyglucose uptake. The amygdala, hippocampus, and cingulate gyrus were outlined on magnetic resonance imaging scans, volumes of the structures were applied to matching coregistered positron emission tomography scans, and three-dimensional significance probability mapping was performed. RESULTS: Significant metabolic reductions in both the anterior and posterior cingulate gyri were visualized in the patients with autism spectrum disorders. Both Asperger's and autism patients had relative glucose hypometabolism in the anterior and posterior cingulate as confirmed by analysis of variance; regional differences were also found with three-dimensional significance probability mapping. No group differences were found in either the metabolism or the volume of the amygdala or the hippocampus. However, patients with autism spectrum disorders showed reduced volume of the right anterior cingulate gyrus, specifically in Brodmann's area 24'. CONCLUSIONS: Compared with age- and sex-matched healthy volunteers, patients with autism spectrum disorders showed significantly decreased metabolism in both the anterior and posterior cingulate gyri.
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Several neuroimaging studies have found support for a hypofunctional ACC in autism.
“Concerning ASD, several neuroimaging studies have found support for a hypofunctional ACC in autism (Gomot et al., 2006; Haznedar et al., 2000; Ohnishi et al., 2000)”
From Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: An EEG event-related potential study (2008) · cites this paper as Haznedar et al., 2000
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- Authors
- Haznedar, M. M., Buchsbaum, M. S., Wei, T.-C., Hof, P. R., Cartwright, C., Bienstock, C. A., & Hollander, E.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Venue
- American Journal of Psychiatry
- Published
- 2000-12-01
- Volume
- 157
- Issue
- 12
- Pages
- 1994-2001
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2119674528
- Cited by
- 420
- References
- 28
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 18 · 2023: 5 · 2022: 16 · 2021: 15 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 13 · 2016: 13 · 2015: 24 · 2014: 18 · 2013: 21 · 2012: 19
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, Asperger syndrome, anterior cingulate cortex, posterior cingulate cortex, glucose hypometabolism, amygdala, hippocampus, limbic system, brain volume, regional cerebral glucose metabolism
- MeSH terms
- Adult, Amygdala, Autistic Disorder, Female, Glucose, Gyrus Cinguli, Hippocampus, Humans, Limbic System, Magnetic Resonance Imaging, Male, Task Performance and Analysis, Tomography, Emission-Computed, Verbal Learning, Fluorodeoxyglucose F18, Asperger Syndrome
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