Diffusion Tensor Imaging Analysis of Frontal Lobes in Pediatric Traumatic Brain Injury
Open accessAbstract
This study examined the use of diffusion tensor imaging in detecting white matter changes in the frontal lobes following pediatric traumatic brain injury. A total of 46 children (ages 8-16 years) with moderate to severe traumatic brain injury and 47 children with orthopedic injury underwent 1.5 Tesla magnetic resonance imaging (MRI) at 3 months postinjury. Conventional MRI studies were obtained along with diffusion tensor imaging. Diffusion tensor imaging metrics, including fractional anisotropy, apparent diffusion coefficient, and radial diffusivity, were compared between the groups. Significant group differences were identified, implicating frontal white matter alterations in the injury group that were predictive of later Glasgow Outcome Scale ratings; however, focal lesions were not related to the Glasgow Outcome Scale ratings. Injury severity was also significantly associated with diffusion tensor imaging metrics. Diffusion tensor imaging holds great promise as an index of white matter integrity in traumatic brain injury and as a potential biomarker reflective of outcome.
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Diffusion tensor imaging provides information about the white matter microstructure and fiber tract integrity and is emerging as a valuable tool in refining the diagnosis, prognosis, and management of mTBI.
“Diffusion tensor imaging (DTI), however, provides information about the white matter microstructure and fiber tract integrity and is emerging as a valuable tool in refining the diagnosis, prognosis, and management of mTBI [5, 149, 196].”
From The neuropathology of sport (2014) · cites this paper as [149]
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McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422 · see citing works
- Authors
- Oni, M. B., Wilde, E. A., Bigler, E. D., McCauley, S. R., Wu, T. C., Yallampalli, R., Chu, Z., Li, X., Hunter, J. V., Vasquez, A. C., & Levin, H. S.
- Affiliations
- Baylor College of Medicine (US)
- Brigham Young University (US)
- Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas
- ORCID
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 2010-03-23
- Volume
- 25
- Issue
- 8
- Pages
- 976-984
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- PMC
- PMC3227397
- OpenAlex
- W1964969158
- Cited by
- 73
- References
- 49
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 9 · 2016: 1 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 9
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS021889, NS021889)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- pediatric traumatic brain injury, diffusion tensor imaging, frontal lobe, white matter integrity, fractional anisotropy, apparent diffusion coefficient, radial diffusivity, Glasgow Outcome Scale, injury severity, outcome prediction, biomarkers
- MeSH terms
- Adolescent, Brain Injuries, Child, Diffusion, Female, Frontal Lobe, Humans, Male, Nerve Fibers, Myelinated, Predictive Value of Tests, Prognosis, Prospective Studies, Biomarkers, Anisotropy, Glasgow Outcome Scale, Diffusion Tensor Imaging
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