The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder: The Role of Endocrine Disruptors in Autism Etiopathogenesis
Abstract
The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), and bisphenol A (BPA), 1 of the endocrine disruptors, among phthalates. The study included 48 children with autism spectrum disorder (27 boys, 21 girls) and 41 healthy subjects (24 boys, 17 girls) as controls. Serum MEHP, DEHP, and BPA levels were measured by using high-performance liquid chromatography. Children with autism spectrum disorder had significantly increased serum MEHP, DEHP, and BPA concentrations (0.47 ± 0.14 µg/ml, 2.70 ± 0.90 µg/ml, 1.25 ± 0.30 ng/ml) compared to healthy control subjects (0.29 ± 0.05 µg/ml, 1.62 ± 0.56 µg/ml, 0.88 ± 0.18 ng/ml) respectively ( P = .000). The fact that higher serum MEHP, DEHP, and BPA were found levels in the autism spectrum disorder group compared to healthy controls suggests that endocrine disruptors may have a role in the pathogenesis of autism spectrum disorders.
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“Concerning bisphenol A, the published literature, mostly characterized by smaller case–control studies is also conflicting, reporting associations ranging from none to rather substantial links with clinical autism and autistic traits [203–206].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [204]
Citations
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Items 101–113 of 113
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Kanlayaprasit, S., Saeliw, T., Thongkorn, S., Panjabud, P., Kasitipradit, K., Lertpeerapan, P., Songsritaya, K., Yuwattana, W., Jantheang, T., Jindatip, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26720943
Kanlayaprasit, S., Saeliw, T., Thongkorn, S., Panjabud, P., Kasitipradit, K., Lertpeerapan, P., Songsritaya, K., Yuwattana, W., Jantheang, T., Jindatip, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25834257
Kanlayaprasit, S., Saeliw, T., Thongkorn, S., Panjabud, P., Kasitipradit, K., Lertpeerapan, P., Songsritaya, K., Yuwattana, W., Jantheang, T., Jindatip, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26720934
Kanlayaprasit, S., Saeliw, T., Thongkorn, S., Panjabud, P., Kasitipradit, K., Lertpeerapan, P., Songsritaya, K., Yuwattana, W., Jantheang, T., Jindatip, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26720925
Chemical Characterization of Toxic Elements in Plastic Utensils: Key Insights and Health Impacts
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Geng, J., Cao, L., Ni, C., Zhang, Y., Wei, Y., Shi, J., Liu, Y., Zhang, Q., Zhu, Y. L., Yuan, Q., et al. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.142699
Zheng, G., Wang, L., Wang, G., Zhang, Y., Han, X., Qiu, G., Sun, Y., Pei, L., Wu, S., & Li, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146317
Phthalates and Bisphenols as Endocrine-Disrupting Chemicals: Possible Determinants of Mood Disorders
Lastretti, M., Faa, A., Piras, M., Dessì, A., Paribello, P., Piludu, M., Orrù, G., Manchia, M., Faa, G., & Fanos, V. (2026) · Environments · doi:10.3390/environments13080425
Yang, G., Gong, C., Zheng, X., Chen, H., Wang, Y., Zhang, H., Hu, F., Wan, J., Zhu, Z., Sun, X., et al. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120659
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Metadata
- Authors
- Kardas, F., Bayram, A. K., Demirci, E., Akin, L., Ozmen, S., Kendirci, M., Canpolat, M., Oztop, D. B., Narin, F., Gumus, H., Kumandas, S., & Per, H.
- Affiliations
- Department of Pediatrics, Division of Pediatric Nutrition and Metabolism, School of Medicine, Erciyes University, Kayseri, Turkey
- Department of Pediatrics, Division of Pediatric Neurology, School of Medicine, Erciyes University, Kayseri, Turkey
- Department of Child Psychiatry, School of Medicine, Erciyes University, Kayseri, Turkey
- Department of Pediatrics, Division of Pediatric Endocrinology, School of Medicine, Erciyes University, Kayseri, Turkey
- Erciyes University (TR)
- Venue
- Journal of Child Neurology
- Publisher
- SAGE Publications
- Published
- 2015-10-08
- Volume
- 31
- Issue
- 5
- Pages
- 629-635
- ISSN
- 0883-0738 (ISSN-L)
- 1708-8283
- OpenAlex
- W1929491033
- Cited by
- 107
- References
- 40
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 16 · 2023: 9 · 2022: 6 · 2021: 17 · 2020: 16 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 4 · 2015: 1
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- autism spectrum disorder, phthalates, mono(2-ethylhexyl) phthalate, DEHP, bisphenol A, endocrine disruptors, serum biomarkers, children, autism pathogenesis, environmental exposure
- MeSH terms
- Autism Spectrum Disorder, Bisphenol A Compounds, Benzhydryl Compounds, Child, Child, Preschool, Chromatography, High Pressure Liquid, Diethylhexyl Phthalate, Female, Humans, Male, Phenols
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