Cited by 113Effects and risks of endocrine disrupting chemicalsAutism Spectrum Disorder ResearchSexual Differentiation and Disorders

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Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder: The Role of Endocrine Disruptors in Autism Etiopathogenesis

Kardas, Fatih, Bayram, Ayse Kacar, Demirci, Esra, Akin, Leyla, Ozmen, Sevgi, Kendirci, Mustafa, Canpolat, Mehmet, Oztop, Didem Behice, Narin, Figen, Gumus, Hakan, Kumandas, Sefer, Per, Huseyin·2016·Journal of Child Neurology

DOI 10.1177/0883073815609150

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Abstract

The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), and bisphenol A (BPA), 1 of the endocrine disruptors, among phthalates. The study included 48 children with autism spectrum disorder (27 boys, 21 girls) and 41 healthy subjects (24 boys, 17 girls) as controls. Serum MEHP, DEHP, and BPA levels were measured by using high-performance liquid chromatography. Children with autism spectrum disorder had significantly increased serum MEHP, DEHP, and BPA concentrations (0.47 ± 0.14 µg/ml, 2.70 ± 0.90 µg/ml, 1.25 ± 0.30 ng/ml) compared to healthy control subjects (0.29 ± 0.05 µg/ml, 1.62 ± 0.56 µg/ml, 0.88 ± 0.18 ng/ml) respectively ( P = .000). The fact that higher serum MEHP, DEHP, and BPA were found levels in the autism spectrum disorder group compared to healthy controls suggests that endocrine disruptors may have a role in the pathogenesis of autism spectrum disorders.

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Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,772
Autism as a strongly genetic disorder: evidence from a British twin study
Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995) · Psychological Medicine · doi:10.1017/s0033291700028099 · Cited by 2,461
Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS)
Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. (1980) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02408436 · Cited by 2,432
Autism
Lai, M.-C., Lombardo, M. V., & Baron-Cohen, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61539-1 · Cited by 2,371
Bisphenol A and human health: A review of the literature
Rochester, J. R. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.08.008 · Cited by 2,018
Prevalence of Autism Spectrum Disorders in a Total Population Sample
Kim, Y. S., Leventhal, B. L., Koh, Y.-J., Fombonne, E., Laska, E., Lim, E.-C., Cheon, K.-A., Kim, S.-J., Kim, Y.-K., Lee, H., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10101532 · Cited by 1,524
The genetics of autism
Muhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 940
A Physiologically Based Approach To the Study of Bisphenol a and Other Estrogenic Chemicals On the Size of Reproductive Organs, Daily Sperm Production, and Behavior
Saal, F. S. V., Cooke, P. S., Buchanan, D. L., Palanza, P., Thayer, K. A., Nagel, S. C., Parmigiani, S., & Welshons, W. V. (1998) · Toxicology and Industrial Health · doi:10.1177/074823379801400115 · Cited by 757
Organophosphate Pesticide Exposure and Neurodevelopment in Young Mexican-American Children
Eskenazi, B., Marks, A. R., Bradman, A., Harley, K. G., Barr, D. B., Johnson, C. B., Morga, N., & Jewell, N. P. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9828 · Cited by 716
Metabolism of phthalates in humans
Frederiksen, H., Skakkebaek, N. E., & Andersson, A. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600243 · Cited by 652
Autism
Levy, S. E., Mandell, D. S., & Schultz, R. T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61376-3 · Cited by 651
Traffic-Related Air Pollution, Particulate Matter, and Autism
Volk, H. E., Lurmann, F., Penfold, B., Hertz-Picciotto, I., & McConnell, R. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.266 · Cited by 638
Environmental toxicants and autism spectrum disorders: a systematic review
Rossignol, D. A., Genuis, S. J., & Frye, R. E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.4 · Cited by 458
Prenatal phthalate exposure is associated with childhood behavior and executive functioning
Engel, S. M., Miodovnik, A., Canfield, R. L., Zhu, C., Silva, M. J., Calafat, A. M., & Wolff, M. S. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901470 · Cited by 441
Elevated maternal C-reactive protein and autism in a national birth cohort
Brown, A. S., Sourander, A., Hinkka-Yli-Salomäki, S., McKeague, I. W., Sundvall, J., & Surcel, H.-M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.197 · Cited by 343
Defining key features of the broad autism phenotype: A comparison across parents of multiple‐ and single‐incidence autism families
Losh, M., Childress, D., Lam, K., & Piven, J. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30612 · Cited by 316
Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice
Wolstenholme, J. T., Taylor, J. A., Shetty, S. R. J., Edwards, M., Connelly, J. J., & Rissman, E. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025448 · Cited by 169 · cited 1×
“It has been reported that gestational exposure to BPA can influence social interactions in juvenile mice.(18) In the present study, the authors investigated the relationship between autism and endocrine disruptors such as phthalates (MEHP, DEHP), and BPA exposure.”
Background
Autism and environmental genomics
Herbert, M. R., Russo, J. P., Yang, S., Roohi, J., Blaxill, M. F., Kahler, S. G., Cremer, L., & Hatchwell, E. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.03.017 · Cited by 167
Di-(2-Ethylhexyl) Phthalate and Autism Spectrum Disorders
Testa, C., Nuti, F., Hayek, J., Felice, C. D., Chelli, M., Rovero, P., Latini, G., & Papini, A. M. (2012) · ASN NEURO · doi:10.1042/an20120015 · Cited by 150
Autism genetics: strategies, challenges, and opportunities
O'Roak, B. J., & State, M. W. (2008) · Autism Research · doi:10.1002/aur.3 · Cited by 150
Urinary Phthalates and Increased Insulin Resistance in Adolescents
Trasande, L., Spanier, A. J., Sathyanarayana, S., Attinà, T. M., & Blustein, J. (2013) · PEDIATRICS · doi:10.1542/peds.2012-4022 · Cited by 142
Toxicological Profile for Diethyl Phthalate
(2002) · CRC Press eBooks · doi:10.1201/9781420061888_ch74 · Cited by 123
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to 2,2-BIS(4-HYDROXYPHENYL)PROPANE
(EFSA), E. F. S. A. (2007) · EFSA Journal · doi:10.2903/j.efsa.2007.428 · Cited by 116
Bisphenol A and cardiometabolic risk factors in obese children
Khalil, N., Ebert, J. R., Wang, L., Belcher, S. M., Lee, M., Czerwinski, S. A., & Kannan, K. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.09.088 · Cited by 106
Exposure to diethylhexyl phthalate (DEHP) results in a heritable modification of imprint genes DNA methylation in mouse oocytes
Li, L., Zhang, T., Qin, X.-S., Ge, W., Ma, H.-G., Sun, L.-L., Hou, Z.-M., Chen, H., Chen, P., Qin, G., et al. (2014) · Molecular Biology Reports · doi:10.1007/s11033-013-2967-7 · Cited by 105
The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls
Akın, L., Kendırcı, M., Narin, F., Kurtoğlu, S., Saraymen, R., Kondolot, M., Koçak, S. Ö., & Elmalı, F. (2014) · Acta Paediatrica · doi:10.1111/apa.12885 · Cited by 105
Self-citation
Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands
Roelfsema, M. T., Hoekstra, R. A., Allison, C., Wheelwright, S., Brayne, C., Matthews, F. E., & Baron-Cohen, S. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1302-1 · Cited by 101
Bisphenol A induces oxidative stress and mitochondrial dysfunction in lymphoblasts from children with autism and unaffected siblings
Kaur, K., Chauhan, V. P. S., Gu, F., & Chauhan, A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.030 · Cited by 100
Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring
Jiang, Y., Xia, W., Zhu, Y., Li, X., Wang, D., Liu, J., Chang, H., Li, G., Xu, B., Chen, X., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.04.013 · Cited by 95
Flawed Experimental Design Reveals the Need for Guidelines Requiring Appropriate Positive Controls in Endocrine Disruption Research
Saal, F. S. V., Akingbemi, B. T., Belcher, S. M., Crain, D. A., Crews, D. P., Guidice, L. C., Hunt, P. A., Leranth, C., Myers, J. P., Nadal, Á., et al. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq048 · Cited by 81
Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation and mitochondrial dysfunction in the testis
Li, X., Fang, E. F., Scheibye‐Knudsen, M., Cui, H., Qiu, L., Li, J., He, Y., Huang, J., Bohr, V. A., Ng, T. B., et al. (2014) · Scientific Reports · doi:10.1038/srep06434 · Cited by 70
High-performance liquid chromatographic analysis of bisphenol A and 4-nonylphenol in serum, liver and testis tissues after oral administration to rats and its application to toxicokinetic study
Xiao, Q., Li, Y., Ouyang, H., Xu, P., & Wu, D. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.11.024 · Cited by 69
BPA-induced DNA hypermethylation of the master mitochondrial gene PGC-1α contributes to cardiomyopathy in male rats
Jiang, Y., Xia, W., Yang, J., Zhu, Y., Chang, H., Liu, J., Huo, W., Xu, B., Chen, X., Li, Y., et al. (2015) · Toxicology · doi:10.1016/j.tox.2015.01.001 · Cited by 61
Autism and Phthalate Metabolite Glucuronidation
Stein, T. P., Schluter, M. D., Steer, R. A., & Ming, X. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1822-y · Cited by 45
Mono-2-Ethylhexyl Phthalate Stimulates Androgen Production but Suppresses Mitochondrial Function in Mouse Leydig Cells With Different Steroidogenic Potential
Savchuk, I., Söder, O., & Svechnikov, K. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv042 · Cited by 38
Exposure to Environmental Toxins in Mothers of Children with Autism Spectrum Disorder
Kim, S. M., Han, D. H., Lyoo, H. S., Min, K. J., Kim, K. H., & Renshaw, P. F. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.2.122 · Cited by 37
Simultaneous Determination of Di(2-Ethylhexyl)phthalate and Mono(2-Ethylhexyl)phthalate in Human Plasma by High-Performance Liquid Chromatography
Paris, I., Ruggieri, F., Mazzeo, P., & Carlucci, G. (2003) · Analytical Letters · doi:10.1081/al-120024639 · Cited by 19
The Role of Endocrine Disruptors in Pubertal Development
Nebesio, T. D., & Pescovitz, O. H. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-499-5_20 · Cited by 11
Environmental Exposures That Increase the Risk of Autism Spectrum Disorders
Rodier, P. M. (2011) · Autism Spectrum Disorders · doi:10.1093/med/9780195371826.003.0055 · Cited by 11

Research works printed but not linked: 3

Agency for Toxic Substances and Disease Registry, 1995, Toxicological Profile for Diethylphthalate
Krug DA, 1993, Autism Screening Instrument for Educational Planning
Yeşilkaya E., 2008, J Current Pediatr, 6, 76

Sorted by citations

A Review of Biomonitoring of Phthalate Exposures
Wang, Y., Zhu, H., & Kannan, K. (2019) · Toxics · doi:10.3390/toxics7020021 · Cited by 755
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Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509
Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs
EFSA Panel on Food Contact Materials, E. A. P. A. (., Lambré, C., Baviera, J. M. B., Bolognesi, C., Chesson, A., Cocconcelli, P. S., Crebelli, R., Gott, D. M., Grob, K., Lampi, E., et al. (2023) · EFSA Journal · doi:10.2903/j.efsa.2023.6857 · Cited by 469
Phthalate exposure and neurodevelopment: A systematic review and meta-analysis of human epidemiological evidence
Radke, E. G., Braun, J. M., Nachman, R. M., & Cooper, G. S. (2020) · Environment International · doi:10.1016/j.envint.2019.105408 · Cited by 250
Developmental and behavioral alterations in zebrafish embryonically exposed to valproic acid (VPA): An aquatic model for autism
Chen, J., Lei, L., Tian, L., Hou, F., Roper, C., Ge, X., Zhao, Y., Chen, Y., Dong, Q., Tanguay, R. L., et al. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2018.01.002 · Cited by 125

See all 113

Authors: Kardas, F., Bayram, A. K., Demirci, E., Akin, L., Ozmen, S., Kendirci, M., Canpolat, M., Oztop, D. B., Narin, F., Gumus, H., Kumandas, S., & Per, H.
Affiliations: Department of Pediatrics, Division of Pediatric Nutrition and Metabolism, School of Medicine, Erciyes University, Kayseri, Turkey
Department of Pediatrics, Division of Pediatric Neurology, School of Medicine, Erciyes University, Kayseri, Turkey
Department of Child Psychiatry, School of Medicine, Erciyes University, Kayseri, Turkey
Department of Pediatrics, Division of Pediatric Endocrinology, School of Medicine, Erciyes University, Kayseri, Turkey
Erciyes University (TR)
ORCID: Canpolat, Mehmet
Narin, Figen
Venue: Journal of Child Neurology
Publisher: SAGE Publications
Published: 2015-10-08
Volume: 31
Issue: 5
Pages: 629-635
ISSN: 0883-0738 (ISSN-L)
1708-8283
DOI: 10.1177/0883073815609150
OpenAlex: W1929491033
Cited by: 107
References: 40
Citations by year: 2026: 9 · 2025: 4 · 2024: 16 · 2023: 9 · 2022: 6 · 2021: 17 · 2020: 16 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 4 · 2015: 1
FWCI: 4.18
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Child Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: autism spectrum disorder, phthalates, mono(2-ethylhexyl) phthalate, DEHP, bisphenol A, endocrine disruptors, serum biomarkers, children, autism pathogenesis, environmental exposure
MeSH terms: Autism Spectrum Disorder, Bisphenol A Compounds, Benzhydryl Compounds, Child, Child, Preschool, Chromatography, High Pressure Liquid, Diethylhexyl Phthalate, Female, Humans, Male, Phenols

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Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder: The Role of Endocrine Disruptors in Autism Etiopathogenesis

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