The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Minocycline hydrochloride loaded mPEG-PCLA membranes: Preparation and in vitro evaluation for periodontitis therapy
Abstract
This study was aimed at alleviating shortcomings in the treatment of periodontitis by preparation of a biopolymer membrane loaded with minocycline hydrochloride (MH) inserted into periodontal pockets to treat infections. Monomethoxy-poly (ethylene glycol)-poly (ε-caprolactone-co-L-lactide) (mPEG-PCLA) is a biocompatible and biodegradable amphiphilic block copolymer. It, therefore, has attracted considerable attention in drug delivery systems and periodontal treatment. We chose it as a membrane material for MH-drug loading. The MH-loaded membranes were prepared by the solvent casting technique with the content of 5, 8 and 10 wt.%, respectively. Fourier transform infrared spectra (FTIR) revealed no interaction between MH and polymer. The drug-loaded membrane surface morphology was investigated by scanning electron microscopy (SEM). In vitro release studies showed that the initial drug release exceeded 40% within 24 h, followed by a sustained release for up to 2 weeks, which would enable the therapeutic level to maintain over a longer time. The antibacterial activity studies in vitro demonstrated a positive effect on the periodontal pathogen. MH drug-loaded membranes have no adverse effect on the growth of periodontal ligament fibroblasts in the MTT test. The study suggests that mPEG-PCLA membranes containing MH are a potential antibacterial drug delivery system for local treatment of periodontitis.
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Cites
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Cited by
Azhari, Z., Smith, P. C., McMahon, S., Wang, W., & Cameron, R. E. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03228-8 · Cited by 8
Kumar, A., Verma, A. K., Chandra, P., & Rastogi, V. (2025) · Current Drug Discovery Technologies · doi:10.2174/0115701638353043250613185624
Wang, X., Liu, P., Chen, X., Zhou, H., Jiang, T., Gao, P., & Kuang, X. (2026) · ACS Applied Bio Materials · doi:10.1021/acsabm.6c00068
Metadata
- Authors
- Wang, N., Huang, Z., Wang, S., Lang, M., & Zhang, X.
- Affiliations
- Shanghai Jiao Tong University (CN)
- School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China
- East China University of Science and Technology (CN)
- Corresponding author
- Zhang, Xiuyin
- Venue
- Journal of Bioactive and Compatible Polymers
- Publisher
- SAGE Publications
- Published
- 2021-04-16
- Volume
- 36
- Issue
- 3
- Pages
- 212-224
- ISSN
- 0883-9115 (ISSN-L)
- 1530-8030
- OpenAlex
- W3154097394
- Semantic Scholar
- cd44a1c555d511d7de26a1121e5f0c9ef2cc3f8d
- Cited by
- 3
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1
- FWCI
- 0.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
- Locations
- Journal of Bioactive and Compatible Polymers (publishedVersion)
- Funders
- National Natural Science Foundation of China (No. 81070857)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Keywords
- minocycline hydrochloride, periodontitis, periodontal pockets, antibacterial drug delivery, sustained drug release, periodontal ligament fibroblasts, periodontal pathogens, biodegradable block copolymers, solvent casting
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- The paper
- Wang, N., Huang, Z., Wang, S., Lang, M., & Zhang, X. (2021). Minocycline hydrochloride loaded mPEG-PCLA membranes: Preparation and in vitro evaluation for periodontitis therapy. Journal of Bioactive and Compatible Polymers. https://doi.org/10.1177/0883911521992795
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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