Cited by 101Curcumin's Biomedical ApplicationsAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

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Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications

Udompornmongkol, Panisa, Chiang, Been-Huang·2015·Journal of Biomaterials Applications

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Abstract

The purpose of the present study was to fabricate polymeric nanoparticles as drug carriers for encapsulated curcumin with enhanced anti-colorectal cancer applications. Nanoparticles were formulated from chitosan and gum arabic, natural polysaccharides, via an emulsification solvent diffusion method. The formation of curcumin nanoparticles was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimeter. The results show that curcumin was entrapped in carriers with +48 mV, 136 nm size, and high encapsulation efficiency (95%). Based on an in vitro release study, we inferred that curcumin nanoparticles could tolerate hydrolysis due to gastric juice or small intestinal enzymes, and therefore, it should reach the colon largely intact. In addition, curcumin nanoparticles had higher anti-colorectal cancer properties than free curcumin due to greater cellular uptake. Therefore, we concluded that curcumin was successfully encapsulated in chitosan-gum arabic nanoparticles with superior anti-colorectal cancer activity.

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Authors: Udompornmongkol, P., & Chiang, B.-H.
Affiliations: National Taiwan University (TW)
Corresponding author: Chiang, Been-Huang
ORCID: Chiang, Been-Huang
Venue: Journal of Biomaterials Applications
Publisher: SAGE Publications
Published: 2015-07-13
Volume: 30
Issue: 5
Pages: 537-546
ISSN: 0885-3282 (ISSN-L)
1530-8022
DOI: 10.1177/0885328215594479
OpenAlex: W1414029200
Cited by: 101
References: 45
Citations by year: 2026: 5 · 2025: 13 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 7 · 2017: 6 · 2016: 5
FWCI: 2.11
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Biomaterials Applications (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: curcumin, polymeric nanoparticles, chitosan, gum arabic, colorectal cancer, drug delivery, encapsulation efficiency, in vitro drug release, cellular uptake, anticancer activity
MeSH terms: Antineoplastic Agents, Cell Survival, Colon, Curcumin, Drug Carriers, Gum Arabic, Humans, Hydrolysis, Rectum, Colorectal Neoplasms, Cell Line, Tumor, Chitosan, Nanoparticles

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Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications

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