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Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications
Abstract
The purpose of the present study was to fabricate polymeric nanoparticles as drug carriers for encapsulated curcumin with enhanced anti-colorectal cancer applications. Nanoparticles were formulated from chitosan and gum arabic, natural polysaccharides, via an emulsification solvent diffusion method. The formation of curcumin nanoparticles was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimeter. The results show that curcumin was entrapped in carriers with +48 mV, 136 nm size, and high encapsulation efficiency (95%). Based on an in vitro release study, we inferred that curcumin nanoparticles could tolerate hydrolysis due to gastric juice or small intestinal enzymes, and therefore, it should reach the colon largely intact. In addition, curcumin nanoparticles had higher anti-colorectal cancer properties than free curcumin due to greater cellular uptake. Therefore, we concluded that curcumin was successfully encapsulated in chitosan-gum arabic nanoparticles with superior anti-colorectal cancer activity.
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“10.1016/j.bcp.2009.09.003”
Cited work 10.1016/j.bcp.2009.09.003 · retracted 2016-02-15 · notice 10.1016/j.bcp.2015.11.008 · this paper published 2015-07-13
Citations
Cites
1 retracted
Anand, P., Nair, H. B. B., Sung, B., Kunnumakkara, A. B., Yadav, V. R., TEKMAL, R. R., & Aggarwal, B. B. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.003 · Cited by 575
RetractedBioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Curcumin as “Curecumin”: From kitchen to clinic
Goel, A., Kunnumakkara, A. B., & Aggarwal, B. B. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.016 · Cited by 2,274
Antioxidant and radical scavenging properties of curcumin
Ak, T. P., & Gülçın, İ. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.05.003 · Cited by 1,942
Stability of curcumin in buffer solutions and characterization of its degradation products
Wang, Y., Pan, M., Cheng, A., Lin, L., Ho, Y., Hsieh, C., & Lin, J. (1997) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(96)02024-9 · Cited by 1,709
Sharma, R. A., Gescher, A. J., & Steward, W. P. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.05.009 · Cited by 1,701
Bisht, S., Feldmann, G., Soni, S., Ravi, R. K., Karikar, C., Maitra, A., & Maitra, A. (2007) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-5-3 · Cited by 1,113
Kunnumakkara, A. B., Anand, P., & Aggarwal, B. B. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.009 · Cited by 1,083
Chitosan: A Unique Polysaccharide for Drug Delivery
Felt, O., Buri, P. A., & Gurny, R. (1998) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049809089942 · Cited by 774
Das, R. K., Kasoju, N., & Bora, U. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.05.009 · Cited by 646
Kawamori, T., Lubet, R., Steele, V. E., Kelloff, G. J., Kaskey, R. B., Rao, C. V., & Reddy, B. S. (1999) · PubMed · Cited by 589
Chitosan-Based Particles as Controlled Drug Delivery Systems
Prabaharan, M., & Mano, J. F. (2004) · Drug Delivery · doi:10.1080/10717540590889781 · Cited by 564
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications
Vauthier, C., Dubernet, C., Fattal, E., Pinto‐Alphandary, H., & Couvreur, P. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(03)00041-3 · Cited by 537
Anitha, A., Deepagan, V. G., Rani, V. V. D., Menon, D., Nair, S. V., & Jayakumar, R. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.01.005 · Cited by 523
Niwa, T., Takeuchi, H., Hino, T., Kunou, N., & Kawashimà, Y. (1993) · Journal of Controlled Release · doi:10.1016/0168-3659(93)90097-o · Cited by 480
SPECTRAL AND PHOTOCHEMICAL PROPERTIES OF CURCUMIN
Chignell, C. F., Bilskj, P., Reszka, K. J., Motten, A. G., Sik, R. H., & Dahl, T. A. (1994) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1994.tb05037.x · Cited by 441
Role of Curcumin in Cancer Therapy
Shishodia, S., Chaturvedi, M. M., & Aggarwal, B. B. (2007) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2007.04.001 · Cited by 413
Evaluation of infrared spectroscopic techniques for analysing chitosan
Domszy, J. G., & Roberts, G. A. F. (1985) · Die Makromolekulare Chemie · doi:10.1002/macp.1985.021860815 · Cited by 408
Goel, A., Boland, C. R., & Chauhan, D. P. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00655-3 · Cited by 384
Anitha, A., Maya, S., Deepa, N., Chennazhi, K. P., Nair, S. V., Tamura, H., & Jayakumar, R. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.08.008 · Cited by 353
Li, M., & Feng, S. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00440-0 · Cited by 288
Sun, J., Bi, C., Chan, H. M., Sun, S., Zhang, Q., & Zheng, Y. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.06.032 · Cited by 277
Espinosa‐Andrews, H., Sandoval-Castilla, O., Vázquez‐Torres, H., Vernon‐Carter, E. J., & Lobato‐Calleros, C. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.08.040 · Cited by 276
Curcumin-loaded biocompatible thermoresponsive polymeric nanoparticles for cancer drug delivery
Rejinold, N. S., Muthunarayanan, M., Divyarani, V. V., Sreerekha, P. R., Chennazhi, K. P., Nair, S. V., Tamura, H., & Jayakumar, R. (2011) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2011.04.006 · Cited by 247
Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery
Lv, Q., Yu, A., Xi, Y., Li, H., Song, Z., Cui, J., Cao, F., & Zhai, G. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.01.014 · Cited by 205
Duan, J., Mansour, H. M., Zhang, Y., Deng, X., Chen, Y., Wang, J., Pan, Y., & Zhao, J. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.01.020 · Cited by 194
Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry
Darżynkiewicz, Z., Halicka, H. D., & Zhao, H. L. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6199-0_9 · Cited by 189
In vitro and cell uptake studies for targeting of ligand anchored nanoparticles for colon tumors
Jain, A., & Jain, S. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.08.008 · Cited by 174
Desai, K. G. H., & Park, H. J. (2005) · Drug Development Research · doi:10.1002/ddr.10416 · Cited by 165
Cellular uptake and anticancer effects of mucoadhesive curcumin-containing chitosan nanoparticles
Chuah, L., Roberts, C. J., Billa, N., Abdullah, S., & Rosli, R. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.01.007 · Cited by 156
Novel carboxymethyl chitin nanoparticles for cancer drug delivery applications
Dev, A., Mohan, J. C., Sreeja, V., Tamura, H., Patzke, G. R., Hussain, F., Weyeneth, S., Nair, S. V., & Jayakumar, R. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.10.038 · Cited by 153
Feng, R., Song, Z., & Zhai, G. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s33607 · Cited by 139
Liu, J., Xu, L., Liu, C., Zhang, D., Wang, S., Deng, Z., Lou, W., Xu, H., Bai, Q., & Ma, J. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.04.036 · Cited by 114
Popat, A., Karmakar, S., Jambhrunkar, S., Xu, C., & Yu, C. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.03.005 · Cited by 110
Studies on the stability of turmeric constituents
Pfeiffer, E., Hoehle, S. I., Sólyom, A. M., & Metzler, M. (2002) · Journal of Food Engineering · doi:10.1016/s0260-8774(02)00264-9 · Cited by 76
Enhanced Apoptotic Effect of Curcumin Loaded Solid Lipid Nanoparticles
Kakkar, V., Bhushan, S., Santosh, K. G., & Pal, K. I. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300209k · Cited by 65
Ehrig, K., Kilinc, M. O., Chen, N. G., Stritzker, J., Buckel, L., Zhang, Q., & Szalay, A. A. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-79 · Cited by 65
Zou, T., Percival, S. S., Cheng, Q., Li, Z., Rowe, C. A., & Gu, L. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.05.006 · Cited by 64
Tiwari, A. (2008) · Journal of Polymer Research · doi:10.1007/s10965-008-9176-4 · Cited by 60
Lu, J., Cai, Y.-J., & Ding, J. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0824-3 · Cited by 48
Yoo, B. K., Baskaran, R., Madheswaran, T., Sundaramoorthy, P., & Kim, H. M. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s61823 · Cited by 47
Annison, G., Trimble, R. P., & Topping, D. L. (1995) · Journal of Nutrition · doi:10.1093/jn/125.2.283 · Cited by 46
The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression.
Kirkpatrick, K. L., Newbold, R. F., & Mokbel, K. (2004) · Journal of Carcinogenesis · doi:10.1186/1477-3163-3-1 · Cited by 38
Yeh, C., Chang, C.-K., Cheng, K., Li, Y., Zhang, Y. W., & Cheng, J. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2011/796723 · Cited by 16
Fluorometric Determination of Vanillin with 4,5-Dimethyl-o-phenylenediamine
Katayama, M., Mukai, Y., & Taniguchi, H. (1987) · Analytical Sciences · doi:10.2116/analsci.3.369 · Cited by 9
Research works printed but not linked: 2
- Kawamori T, 1999, Cancer Res, 59, 597
- Baskaran R, 2014, Int J Nanomedicine, 9, 3119
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Elmowafy, M., Shalaby, K., Elkomy, M. H., Alsaidan, O. A., Gomaa, H. A. M., Abdelgawad, M. A., & Mostafa, E. M. (2023) · Polymers · doi:10.3390/polym15051123 · Cited by 373
Curcumin Nanoformulations for Colorectal Cancer: A Review
Wong, K. E., Ngai, S. C., Chan, K., Lee, L., Goh, B. H., & Chuah, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00152 · Cited by 270
Mehanny, M., Hathout, R. M., Geneidi, A. S., & Mansour, S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.018 · Cited by 190
dos Santos, A. M., Carvalho, S. G., Meneguin, A. B., Sábio, R. M., Gremião, M. P. D., & Chorilli, M. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.026 · Cited by 178
Dietary fiber-based colon-targeted delivery systems for polyphenols
Tang, H.-Y., Fang, Z., & Ng, K. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.04.028 · Cited by 147
Metadata
- Authors
- Udompornmongkol, P., & Chiang, B.-H.
- Affiliations
- National Taiwan University (TW)
- Corresponding author
- Chiang, Been-Huang
- ORCID
- Chiang, Been-Huang
- Venue
- Journal of Biomaterials Applications
- Publisher
- SAGE Publications
- Published
- 2015-07-13
- Volume
- 30
- Issue
- 5
- Pages
- 537-546
- ISSN
- 0885-3282 (ISSN-L)
- 1530-8022
- OpenAlex
- W1414029200
- Cited by
- 101
- References
- 45
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 7 · 2017: 6 · 2016: 5
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomaterials Applications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- curcumin, polymeric nanoparticles, chitosan, gum arabic, colorectal cancer, drug delivery, encapsulation efficiency, in vitro drug release, cellular uptake, anticancer activity
- MeSH terms
- Antineoplastic Agents, Cell Survival, Colon, Curcumin, Drug Carriers, Gum Arabic, Humans, Hydrolysis, Rectum, Colorectal Neoplasms, Cell Line, Tumor, Chitosan, Nanoparticles
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