The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Fibrin Sealant Adhesive Systems: A Review of Their Chemistry, Material Properties and Clinical Applications
Abstract
Fibrin sealants (FS) are the most successful tissue adhesives to date. They have many advantages over adhesive technologies such as cyanoacrylates and marine adhesives in terms of biocompatibility, biodegradation and hemostasis. There are several commercial products in Europe but none in the United States due to the current regulatory stance against pooled plasma blood products. Blood banks and interested investigators have implemented single-and patient autologous-donor production methods with some success. This article will review the history of FS research and development and describe the chemistry of fibrin(ogen) and the production of commercial and research products. Fibrin sealant and purified fibrin characterization is compared and contrasted. The material and adhesive properties are described, and a survey of the clinical applications in which FS has been used is included as well.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Pierschbacher, M. D., & Ruoslahti, E. (1984) · Nature · doi:10.1038/309030a0 · Cited by 3,658
Nature's underwater adhesive specialist
Waite, J. H. (1987) · International Journal of Adhesion and Adhesives · doi:10.1016/0143-7496(87)90048-0 · Cited by 588
Ferry, J. D., & MORRISON, P. R. (1947) · Journal of the American Chemical Society · doi:10.1021/ja01194a066 · Cited by 381
Identification of membrane proteins mediating the interaction of human platelets
Phillips, D. R., Jennings, L. K., & Edwards, H. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.86.1.77 · Cited by 379
FIBRIN SUTURE OF PERIPHERAL NERVES
Young, J. Z., & Medawar, P. B. (1940) · The Lancet · doi:10.1016/s0140-6736(01)07978-8 · Cited by 375
Grinnell, F., Feld, M., & Minter, D. (1980) · Cell · doi:10.1016/0092-8674(80)90526-7 · Cited by 353
Waite, J. H. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32805-9 · Cited by 341
Fibrin glue: the perfect operative sealant?
Gibble, J. W., & Ness, P. M. (1990) · Transfusion · doi:10.1046/j.1537-2995.1990.30891020337.x · Cited by 293
USE OF THROMBIN AND FIBRINOGEN IN SKIN GRAFTING: PRELIMINARY REPORT
CRONKITE, E. P. (1944) · Journal of the American Medical Association · doi:10.1001/jama.1944.02850140022006 · Cited by 214
Bergel, S. (1909) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0029-1201395 · Cited by 197
Cited by
Tough adhesives for diverse wet surfaces
Li, J., Celiz, A. D., Yang, J., Yang, Q., Wamala, I., Whyte, W., Seo, B. R., Vasilyev, N. V., Vlassak, J. J., Suo, Z., et al. (2017) · Science · doi:10.1126/science.aah6362 · Cited by 1,598
Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding
Hickman, D. A., Pawlowski, C. L., Sekhon, U. D. S., Marks, J., & Gupta, A. S. (2018) · Advanced Materials · doi:10.1002/adma.201700859 · Cited by 583
Elastomeric biomaterials for tissue engineering
Chen, Q., Liang, S., & Thouas, G. A. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.05.003 · Cited by 564
Topological Adhesion of Wet Materials
Yang, J., Bai, R., & Suo, Z. (2018) · Advanced Materials · doi:10.1002/adma.201800671 · Cited by 465
Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.
Suh, T. T., Holmbäck, K., Jensen, N. J., Daugherty, C. C., Small, K., Simon, D. I., Potter, S., & Degen, J. L. (1995) · Genes & Development · doi:10.1101/gad.9.16.2020 · Cited by 425
Metadata
- Authors
- Sierra, D. H.
- Venue
- Journal of Biomaterials Applications
- Publisher
- SAGE Publications
- Published
- 1993-04
- Volume
- 7
- Issue
- 4
- Pages
- 309-352
- ISSN
- 0885-3282 (ISSN-L)
- 1530-8022
- OpenAlex
- W2023396624
- Cited by
- 354
- References
- 35
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fibrin Sealant Adhesive Systems: A Review of Their Chemistry, Material Properties and Clinical Applications. https://app.cochat.ai/papers/10.1177/088532829300700402
- The paper
- Sierra, D. H. (1993). Fibrin Sealant Adhesive Systems: A Review of Their Chemistry, Material Properties and Clinical Applications. Journal of Biomaterials Applications. https://doi.org/10.1177/088532829300700402
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
