No Long-Term Effect of Behavioral Treatment on Psychotropic Drug Use for Agitation in Alzheimer's Disease Patients
Abstract
To determine if teaching caregivers behavior management techniques (BMTs) reduces long-term psychotropic use in Alzheimer's disease (AD) patients, we examined 12-month follow-up data from a 4-month randomized study com paring placebo, BMTs, trazodone, and haloperidol for the treatment of agitated behaviors in persons with AD. After 4 months, treatment was allowed with any agent. Between 42.8% and 51% of AD patients received additional psy chotropics between 4 and 12 months. The relative risk of being prescribed any psychotropic drug after the 4-month trial was at or about 1.0 for subjects in each drug arm or placebo arm versus BMTs. We concluded that teaching caregivers BMTs did not diminish long-term prescription of psychotropic drugs. (J Geriatr Psychiatry Neurol 2002; 15:95-98).
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One small study, where participants' agitation levels were unspecified, showed immediate improvement in agitation during bathing compared with the control group.
“One small study, where participants' agitation levels were unspecified, showed immediate improvement in agitation during bathing compared with the control group. 39”
From Non-pharmacological interventions for agitation in dementia: systematic review of randomised controlled trials (2014) · cites this paper as [39]
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- Authors
- Weiner, M. F., Tractenberg, R. E., Sano, M., Logsdon, R., Teri, L., Galasko, D., Gamst, A., Thomas, R., & Thal, L. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- University of California San Diego (US)
- Columbia University (US)
- University of Washington (US)
- Venue
- Journal of Geriatric Psychiatry and Neurology
- Publisher
- SAGE Publications
- Published
- 2002-06
- Volume
- 15
- Issue
- 2
- Pages
- 95-98
- ISSN
- 0891-9887 (ISSN-L)
- 1552-5708
- OpenAlex
- W2113891227
- Cited by
- 22
- References
- 18
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Geriatric Psychiatry and Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 10483)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, agitation, caregiver education, psychotropic drugs, trazodone, haloperidol, long-term drug use
- MeSH terms
- Aged, Alzheimer Disease, Behavior Therapy, Female, Follow-Up Studies, Haloperidol, Humans, Interviews as Topic, Male, Psychiatric Status Rating Scales, Psychomotor Agitation, Psychotropic Drugs, Time Factors, Antipsychotic Agents, Anti-Anxiety Agents, Trazodone, Caregivers
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