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Early-onset Alzheimer’s disease is associated with greater pathologic burden.
Abstract
Two subtypes of Alzheimer's disease (AD) have been commonly identified: early- and late-onset forms. Previous studies suggest that early-onset AD patients have more neuritic plaques (NPs) and neurofibrillary tangles (NFTs). In the current study, NP and NFT counts were performed for 8 brain regions in 25 subjects with definite AD. A repeated-measures analysis of variance of mean regional NP and NFT counts for early- and late-onset groups was performed. A significant between-subject effect indicating greater overall NP and NFT burden in the early-onset group was observed (NP: F = 6.8, df = 1, P = .015; NFT: F = 7.5, df = 1, P = .012). This analysis supports the hypothesis that early-onset AD is associated with greater pathologic burden than late-onset AD. This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration.
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“EOAD patients have shown a greater extent of neuritic plaque and neurofibrillary tangle burden in the frontal and parietal lobes than LOAD patients in postmortem studies (Marshall et al., 2007).”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Marshall et al., 2007
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Metadata
- Authors
- Marshall, G. A., Fairbanks, L. A., Tekin, S., Vinters, H. V., & Cummings, J. L.
- Affiliations
- University of California, Los Angeles (US)
- Florham Park, New Jersey
- Venue
- Journal of Geriatric Psychiatry and Neurology
- Publisher
- SAGE Publications
- Published
- 2007-03
- Volume
- 20
- Issue
- 1
- Pages
- 29-33
- ISSN
- 0891-9887 (ISSN-L)
- 1552-5708
- OpenAlex
- W2069461843
- Cited by
- 143
- References
- 20
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 16 · 2023: 12 · 2022: 10 · 2021: 13 · 2020: 11 · 2019: 5 · 2018: 3 · 2017: 10 · 2016: 6 · 2015: 10 · 2014: 1 · 2013: 9 · 2012: 6
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Geriatric Psychiatry and Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50AG016570)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- early-onset Alzheimer's disease, late-onset Alzheimer's disease, Alzheimer's disease subtypes, neuritic plaques, neurofibrillary tangles, cognitive reserve, cognitive decline
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebral Cortex, Diagnosis, Differential, Dominance, Cerebral, Female, Humans, Male, Middle Aged, Retrospective Studies, Synapses, Cohort Studies, Neurofibrillary Tangles, Plaque, Amyloid
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