Cited by 143Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Early-onset Alzheimer’s disease is associated with greater pathologic burden.

Marshall, Gad A., Fairbanks, Lynn A., Tekin, Sibel, Vinters, Harry V., Cummings, Jeffrey L.·2007·Journal of Geriatric Psychiatry and Neurology

DOI 10.1177/0891988706297086

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Abstract

Two subtypes of Alzheimer's disease (AD) have been commonly identified: early- and late-onset forms. Previous studies suggest that early-onset AD patients have more neuritic plaques (NPs) and neurofibrillary tangles (NFTs). In the current study, NP and NFT counts were performed for 8 brain regions in 25 subjects with definite AD. A repeated-measures analysis of variance of mean regional NP and NFT counts for early- and late-onset groups was performed. A significant between-subject effect indicating greater overall NP and NFT burden in the early-onset group was observed (NP: F = 6.8, df = 1, P = .015; NFT: F = 7.5, df = 1, P = .012). This analysis supports the hypothesis that early-onset AD is associated with greater pathologic burden than late-onset AD. This suggests that late-onset AD patients have less cognitive reserve than early-onset patients and require fewer pathologic changes to exhibit cognitive deterioration.

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Self-citation

Authors: Marshall, G. A., Fairbanks, L. A., Tekin, S., Vinters, H. V., & Cummings, J. L.
Affiliations: University of California, Los Angeles (US)
Florham Park, New Jersey
ORCID: Marshall, Gad A.
Tekin, Sibel
Vinters, Harry V.
Cummings, Jeffrey L.
Venue: Journal of Geriatric Psychiatry and Neurology
Publisher: SAGE Publications
Published: 2007-03
Volume: 20
Issue: 1
Pages: 29-33
ISSN: 0891-9887 (ISSN-L)
1552-5708
DOI: 10.1177/0891988706297086
OpenAlex: W2069461843
Cited by: 143
References: 20
Citations by year: 2026: 5 · 2025: 10 · 2024: 16 · 2023: 12 · 2022: 10 · 2021: 13 · 2020: 11 · 2019: 5 · 2018: 3 · 2017: 10 · 2016: 6 · 2015: 10 · 2014: 1 · 2013: 9 · 2012: 6
FWCI: 2.42
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Geriatric Psychiatry and Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P50AG016570)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: early-onset Alzheimer's disease, late-onset Alzheimer's disease, Alzheimer's disease subtypes, neuritic plaques, neurofibrillary tangles, cognitive reserve, cognitive decline
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebral Cortex, Diagnosis, Differential, Dominance, Cerebral, Female, Humans, Male, Middle Aged, Retrospective Studies, Synapses, Cohort Studies, Neurofibrillary Tangles, Plaque, Amyloid

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Early-onset Alzheimer’s disease is associated with greater pathologic burden.

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