Cited by 103Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Decreased C-Reactive Protein Levels in Alzheimer Disease

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O'Bryant, Sid E., Waring, Stephen C., Hobson, Valerie, Hall, James R., Moore, Carol B., Bottiglieri, Teodoro, Massman, Paul, Diaz-Arrastia, Ramon·2010·Journal of Geriatric Psychiatry and Neurology

DOI 10.1177/0891988709351832PMC PMC3204581

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Abstract

C-reactive protein (CRP) is an acute-phase reactant that has been found to be associated with Alzheimer disease (AD) in histopathological and longitudinal studies; however, little data exist regarding serum CRP levels in patients with established AD. The current study evaluated CRP levels in 192 patients diagnosed with probable AD (mean age = 75.8 ± 8.2 years; 50% female) as compared to 174 nondemented controls (mean age = 70.6 ± 8.2 years; 63% female). Mean CRP levels were found to be significantly decreased in AD (2.9 µg/mL) versus controls (4.9 µg/mL; P = .003). In adjusted models, elevated CRP significantly predicted poorer (elevated) Clinical Dementia Rating Scale sum of boxes (CDR SB) scores in patients with AD. In controls, CRP was negatively associated with Mini-Mental State Examination (MMSE) scores and positively associated with CDR SB scores. These findings, together with previously published results, are consistent with the hypothesis that midlife elevations in CRP are associated with increased risk of AD development though elevated CRP levels are not useful for prediction in the immediate prodrome years before AD becomes clinically manifest. However, for a subgroup of patients with AD, elevated CRP continues to predict increased dementia severity suggestive of a possible proinflammatory endophenotype in AD.

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Authors: O'Bryant, S. E., Waring, S. C., Hobson, V., Hall, J. R., Moore, C. B., Bottiglieri, T., Massman, P., & Diaz-Arrastia, R.
Affiliations: Department of Neurology, F. Marie Hall Institute for Rural & Community Health, Texas Tech University Health Sciences Center, Lubbock, Texas,
Marshfield Clinic Research Foundation (US)
Texas Tech University (US)
University of North Texas Health Science Center (US)
The University of Texas Southwestern Medical Center (US)
Baylor University Medical Center (US)
Baylor College of Medicine (US)
ORCID: Waring, Stephen C.
Hall, James R.
Bottiglieri, Teodoro
Diaz-Arrastia, Ramon
Venue: Journal of Geriatric Psychiatry and Neurology
Publisher: SAGE Publications
Published: 2009-11-20
Volume: 23
Issue: 1
Pages: 49-53
ISSN: 0891-9887 (ISSN-L)
1552-5708
DOI: 10.1177/0891988709351832
PMC: PMC3204581
OpenAlex: W2056433678
Cited by: 103
References: 42
Citations by year: 2026: 4 · 2025: 2 · 2024: 6 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 1 · 2018: 9 · 2017: 6 · 2016: 1 · 2015: 8 · 2014: 5 · 2013: 13 · 2012: 2
FWCI: 3.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Geriatric Psychiatry and Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01 AG17869, P30AG012300, P30AG-12300)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: C-reactive protein, Alzheimer's disease, acute phase proteins, dementia severity, Clinical Dementia Rating, Mini-Mental State Examination, inflammation, prodromal Alzheimer's disease, endophenotypes, serum biomarkers
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, C-Reactive Protein, Dementia, Female, Humans, Immunoassay, Male, Mental Status Schedule, Middle Aged, Predictive Value of Tests, Psychiatric Status Rating Scales, Severity of Illness Index, Time Factors, Biomarkers, Linear Models

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Decreased C-Reactive Protein Levels in Alzheimer Disease

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