Coagulation and inflammatory markers in Alzheimer's and vascular dementia
Abstract
Alzheimer's disease is classified as a degenerative dementia while vascular dementia is known to be associated with atherothrombosis and classical vascular risk factors. However, over the last decade, there is increasing evidence of the role of haemostatic factors and inflammatory mechanisms in the pathogenesis of Alzheimer's disease. Serum markers of hypercoagulability and markers of inflammation could lead to thrombosis, accelerated atherogenesis and resulting dementia of both Alzheimer's and vascular dementia. In this case control study, we studied these serum markers of coagulation and inflammation in patients suffering from dementia.
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Hypercoagulable states may induce micro-vascular disease and induce vascular dementia and Alzheimer's disease.
“Additionally, hypercoagulable states may induce micro-vascular disease and induce vascular dementia and AD [185].”
From Cognitive decline following acute viral infections: literature review and projections for post-COVID-19 (2022) · cites this paper as [185]
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- Authors
- Gupta, A., Watkins, A., Thomas, P., Majer, R., Habubi, N., Morris, G., & Pansari, K.
- Affiliations
- Glangwili General Hospital (GB)
- Corresponding author
- Gupta, A.
- Venue
- International Journal of Clinical Practice
- Publisher
- Wiley
- Published
- 2004-12-23
- Volume
- 59
- Issue
- 1
- Pages
- 52-57
- ISSN
- 1368-5031 (ISSN-L)
- OpenAlex
- W2149524374
- Cited by
- 87
- References
- 62
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 3 · 2021: 10 · 2020: 2 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, vascular dementia, hypercoagulability, coagulation markers, inflammatory markers, hemostatic factors, atherothrombosis, atherogenesis, dementia pathogenesis, serum biomarkers
- MeSH terms
- Alzheimer Disease, Analysis of Variance, Blood Coagulation Disorders, Blood Coagulation Factors, Blood Coagulation Tests, Fibrinogen, Humans, Inflammation, Risk Factors, Dementia, Vascular, Biomarkers, Case-Control Studies
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