Update on anti-phospholipid antibodies in SLE: the Hopkins’ Lupus Cohort
Abstract
Anti-phospholipid antibodies are common in patients in the Hopkins’ Lupus Cohort: 47% have anti-cardiolipin, 32.5% anti-β 2 -glycoprotein I and 26% lupus anticoagulant (by dRVVT confirmatory testing). Systemic lupus erythematosus patients with the lupus anticoagulant at baseline have a 50% chance of a deep venous thrombosis/pulmonary embolus in the next 20 years. Anti-phospholipid antibodies differ in their association with thrombosis: the lupus anticoagulant is most strongly associated with arterial and venous thrombosis and is the only anti-phospholipid antibody associated with myocardial infarction. Anti-phospholipid antibodies are not associated with atherosclerosis. Lupus (2010) 19, 419—423.
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Earlier work reported that lupus anticoagulant was more common in Caucasians.
“While it was previously reported that LAC was more prevalent in Caucasians (15), the association between Hispanic ethnicity and the higher odds of positive aPL and/or LAC has not been previously reported.”
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- Authors
- Petri, M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Petri, M.
- ORCID
- Petri, M.
- Venue
- Lupus
- Publisher
- SAGE Publications
- Published
- 2010-03-30
- Volume
- 19
- Issue
- 4
- Pages
- 419-423
- ISSN
- 0961-2033 (ISSN-L)
- 1477-0962
- OpenAlex
- W1981177602
- Cited by
- 98
- References
- 14
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 11 · 2016: 5 · 2015: 10 · 2014: 1 · 2013: 15 · 2012: 13
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lupus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 43737)
- National Center for Research Resources (M01 RR-00052, M01RR000052)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- antiphospholipid antibodies, systemic lupus erythematosus, anticardiolipin antibodies, anti-beta2-glycoprotein I antibodies, lupus anticoagulant, deep vein thrombosis, pulmonary embolism, arterial thrombosis, myocardial infarction, atherosclerosis
- MeSH terms
- Female, Humans, Longitudinal Studies, Lupus Erythematosus, Systemic, Male, Myocardial Infarction, Pulmonary Embolism, Thrombosis, Time Factors, Cohort Studies, Lupus Coagulation Inhibitor, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin, beta 2-Glycoprotein I
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