Do antibodies to β2-glycoprotein 1 contribute to the better characterization of the antiphospholipid syndrome?
Abstract
The aim of this study was to determine if the measurement of anti-beta2-glycoprotein I antibodies (abeta2-GPI) in serum levels contributes to the better characterization of the clinical situation of patients with antiphospholipid syndrome (APS). For this purpose abeta2-GPI of both isotypes was measured in 42 patients with APS and 32 SLE patients without APS. Clinical records of all patients were thoroughly reviewed. The presence of abeta2-GPI was correlated with the clinical manifestations of APS and compared with the presence of anticardiolipin antibodies (aCL) and lupus anticoagulant (LA) activity. There was a positive correlation between levels of aCL and abeta2-GPI for both IgG and IgM isotypes (rho of Spearman=0.82 and 0. 64 respectively, P=0.0001). Both antibodies presented significantly higher titres in LA positive patients (P<0.05). The specificity for APS was 91% for IgG abeta2-GPI vs 75% for IgG aCL and 87% for IgM abeta2-GPI vs 81% for IgM aCL. 68% of patients with thrombosis of 100% of patients with thrombocytopenia showed positive tests for all three markers (aCL, LA, abeta2-GPI). Simultaneous presence of circulating LA and high titres of both aCL and abeta2-GPI identify a subset of patients with primary APS (PAPS) who have a more severe clinical course of the disease. Although the specificity of abeta2-GPI IgG is higher than that of aCL IgG, when all three tests are performed abeta2-GPI testing provides only additional information to that of aCL and LA. Therefore, we concluded that the abeta2-GPI test should not be considered as a substitute for conventional LA or aCL assays. However, performance of abeta2-GPI seems to be important in PAPS with high aCL titres, to alert the physician about the risk for the worst course of the illness.
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Positivity for multiple antiphospholipid antibody tests is associated with thromboembolic events more frequently than positivity for a single test.
“multiple positivity in tests exploring the presence of antiphospholipid (aPL) antibodies (lupus anticoagulant [LA], anticardiolipin [aCL], and anti- 2 -glycoprotein I [anti- 2 GPI] antibodies) is associated with thromboembolic events (TEs) more frequently than single test positivity.[1][2][3][4][5]”
From Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study (2011) · cites this paper as [1]
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- Authors
- Detková, D., Gil-Aguado, A., Lavilla, P., Cuesta, M. V., Fontaán, G., & Pascual-Salcedo, D.
- Affiliations
- Hospital Universitario La Paz (ES)
- Immunology Unit, Department of Internal Medicine and Hematology Service, Hospital La Paz, Madrid, Spain
- ORCID
- Venue
- Lupus
- Publisher
- SAGE Publications
- Published
- 1999-07
- Volume
- 8
- Issue
- 6
- Pages
- 430-438
- ISSN
- 0961-2033 (ISSN-L)
- 1477-0962
- OpenAlex
- W2073886537
- Cited by
- 41
- References
- 38
- Citations by year
- 2016: 1 · 2015: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lupus (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- antiphospholipid syndrome, anti-beta2-glycoprotein I antibodies, anticardiolipin antibodies, lupus anticoagulant, primary antiphospholipid syndrome, thrombosis, thrombocytopenia, diagnostic specificity, systemic lupus erythematosus
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antibody Specificity, Autoantibodies, Female, Glycoproteins, Humans, Immunoglobulin Isotypes, Male, Middle Aged, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome, beta 2-Glycoprotein I
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