The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Brain-Body Pathways Linking Psychological Stress and Physical Health
Open accessAbstract
Psychological stress is thought to arise from appraisal processes that ascribe threat-related meaning to experiences that tax or exceed our coping ability. Neuroimaging research indicates that these appraisal processes originate in brain systems that also control physiological stress reactions in the body. Separate lines of research in health psychology and behavioral medicine indicate that these physiological stress reactions confer risk for physical disease. Accordingly, integrative research that cuts across historically separated disciplines may help to define the brain-body pathways linking psychological stress to physical health. We describe recent studies aimed at this goal, focusing on studies of the brain bases of stressor-evoked cardiovascular system reactions and heart disease risk. We also outline an interpretive framework for these studies, as well as needs for next-generation models and metrics to better understand how the brain encodes and embodies stress in relation to health.
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“We look at illness-promoting psychological processes that emerge in the minds of children with FND and that function—in a top-down fashion—to activate and modulate the stress system, thereby contributing to the activation or maintenance of the illness process [23,24,25,26,27].”
From Illness-Promoting Psychological Processes in Children and Adolescents with Functional Neurological Disorder (2023) · cites this paper as [25]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The child’s expectations will thus be reflected in her body, thoughts, and feelings and can potentially, through a range of mind–brain–body pathways, affect the course of her symptoms [24,25,27,38,39].”
From Illness-Promoting Psychological Processes in Children and Adolescents with Functional Neurological Disorder (2023) · cites this paper as [25]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Both the actual experience of social rejection and subsequent rejection-related thoughts and feelings function to activate neural networks that mediate the subjective experience of pain (>2/3 of the current cohort) [110,111,112] and stress-system activation (autonomic system component) [25], both of which are known to modulate aberrant neural network function in paediatric FND [39,113].”
From Illness-Promoting Psychological Processes in Children and Adolescents with Functional Neurological Disorder (2023) · cites this paper as [25]
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Citations
Cites
Psychological stress and the coping process
Lazarus, R. S. (1966) · Medical Entomology and Zoology · Cited by 7,164
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Neural regulation of endocrine and autonomic stress responses
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Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Rethinking the Emotional Brain
LeDoux, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.004 · Cited by 1,594 · cited 1×
“In contrast, the amygdala may be crucial for learning associations between aversive events (signaled in part by PAG) and other sensory cues (LeDoux, 2012).”
BackgroundDifferential projections of the infralimbic and prelimbic cortex in the rat
Vertes, R. P. (2004) · Synapse · doi:10.1002/syn.10279 · Cited by 1,550
Cannon, W. B. (1932) · The American Journal of the Medical Sciences · doi:10.1097/00000441-193212000-00028 · Cited by 1,259
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227
Neural mechanisms of autonomic, affective, and cognitive integration
Critchley, H. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20749 · Cited by 1,214
Research works printed but not linked: 2
- Muscatell K. A., Eisenberger N. I. (2012). (See References). A recent review of the neuroimaging literature on stressor-evoked changes in the autonomic, neuroendocrine, and immune systems.
- Roy M., Shohamy D., Wager T. D. (2012). (See References). A review and meta-analysis focusing on the role of the vmPFC as a hub that links meaningful and self-relevant conceptual information about situations, contexts, and other constructs with brainstem areas important for visceral control.
Cited by
Sorted by citations
Items 101–101 of 101
Kozlowska, K., Schollar-Root, O., Savage, B., Hawkes, C., Chudleigh, C., Raghunandan, J., Scher, S., & Helgeland, H. (2023) · Children · doi:10.3390/children10111724 · Cited by 14
“The child’s expectations will thus be reflected in her body, thoughts, and feelings and can potentially, through a range of mind–brain–body pathways, affect the course of her symptoms [24,25,27,38,39].”
Background
Metadata
- Authors
- Gianaros, P. J., & Wager, T. D.
- Affiliations
- University of Pittsburgh (US)
- University of Colorado Boulder (US)
- Venue
- Current Directions in Psychological Science
- Publisher
- SAGE Publications
- Published
- 2015-08
- Volume
- 24
- Issue
- 4
- Pages
- 313-321
- ISSN
- 0963-7214 (ISSN-L)
- 1467-8721
- PMC
- PMC4535428
- OpenAlex
- W2220884112
- Cited by
- 290
- References
- 43
- Citations by year
- 2026: 23 · 2025: 34 · 2024: 33 · 2023: 34 · 2022: 28 · 2021: 24 · 2020: 25 · 2019: 25 · 2018: 28 · 2017: 16 · 2016: 19 · 2015: 1
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Directions in Psychological Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL089850)
- National Institute of Mental Health (R01MH076136, R37MH076136)
- National Institute on Drug Abuse (R01DA035484)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- psychological stress, stress appraisal, physiological stress response, cardiovascular reactivity, heart disease risk
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