The association between post-traumatic stress disorder and coronary artery disease: a meta-analysis
Open accessAbstract
Objectives: There are some psychosocial factors that have similar importance to biological factors in the genesis of coronary diseases. However, reasons for high rates of coronary heart disease in individuals with post-traumatic stress disorder (PTSD) are yet to be fully elucidated. Using a meta-analysis, we investigated the longitudinal relationship between PTSD and coronary heart disease (CHD) as an independent factor in the aetiology of CHD. Methods: The databases of Medline, EBSCOhost and Psychoinfo were electronically searched for relevant articles. Results: The pooled hazard ratio (HR) for the magnitude of the relationship between PTSD and CHD was an HR of 1.61, and p-value of p < 0.0005, 95% confidence interval (CI) [1.46–1.77] before adjustment for depression in nine studies ( N = 151,144) that met inclusion criteria. The HR estimates for the seven depression-adjusted estimates was 1.46, and a p-value of p < 0.0005, 95% CI[0.26–1.69]. Conclusions: This study demonstrates an association between CHD and PTSD.
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PTSD is associated with a 61% increased risk of CHD (HR, 1.61 [95% CI, 1.46-1.77]).
“This analysis found that PTSD was associated with a 61% increased risk of CHD (hazard ratio [HR], 1.61 [95% CI, 1.46-1.77]). 22”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [22]
Individuals rated by trained observers as displaying a more positive affect had a 22% lower risk of incident CHD (HR, 0.78 [95% CI, 0.63-0.96]).
“In a prospective cohort study, individuals who were rated by trained observers as displaying a more positive affect had a 22% lower risk of incident CHD (HR, 0.78 [95% CI, 0.63-0.96]). 22”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [22]
The Results report an association between PTSD and incident CHD (HR 1.61), not between observer-rated positive affect and CHD. Searches for positive affect, trained observers, and the claimed HR of 0.78 found no passage addressing that finding in our copy. (LLM, conf=0.76)
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- Authors
- Akosile, W., Colquhoun, D., Young, R., Lawford, B., & Voisey, J.
- Affiliations
- PhD Candidate, Addiction Medicine specialist and Addiction Psychiatrist, School of Psychology and Counselling, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia
- Greenslopes Private Hospital (AU)
- Queensland University of Technology (AU)
- Venue
- Australasian Psychiatry
- Publisher
- SAGE Publications
- Published
- 2018-08-16
- Volume
- 26
- Issue
- 5
- Pages
- 524-530
- ISSN
- 1039-8562 (ISSN-L)
- 1440-1665
- OpenAlex
- W2886585883
- Semantic Scholar
- 8d177ce9ac23d977d3e661208670523a58cc53cc
- Cited by
- 56
- References
- 22
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 9 · 2020: 1 · 2019: 2 · 2018: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.qut.edu.au
- Locations
- Australasian Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
- Keywords
- post-traumatic stress disorder, coronary artery disease, psychosocial risk factors, depression, cardiovascular risk
- MeSH terms
- Coronary Artery Disease, Depressive Disorder, Humans, Stress Disorders, Post-Traumatic, Comorbidity
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