The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Mechanistic Aspects of the Interactions Between Fluoride and Dental Enamel
Abstract
For many years after the discovery of its caries preventive effect, fluoride was thought to be primarily active by lowering the solubility of the apatitic mineral phase of the dental hard tissues. Recent findings have shed new light on the mechanisms by which fluoride inhibits or delays dental caries. Fluoride present in the oral fluids alters the rate of the naturally occurring dissolution and reprecipitation processes at the tooth-oral fluid interface. Demineralization of enamel is inhibited by concentrations of fluoride in the sub-ppm range. Likewise, remineralization of incipient caries lesions (the earliest stage of enamel caries) is accelerated by trace amounts of fluoride. As these two processes comprise dental caries the physiological balance between hard tissue breakdown and repair is favorably shifted by fluoride. The driving force for both phenomena is thermodynamic, that is, fluorapatite or a fluoridated hydroxyapatite may form when fluoride is supplied at low concentrations. This article critically reviews the current information about tooth-fluoride interactions, both from laboratory and clinical studies.
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Citations
Cites
Alternating Demineralization and Remineralization of Artificial Enamel Lesions
ten Cate, J. M., & Duijsters, P. P. E. (1982) · Caries Research · doi:10.1159/000260599 · Cited by 630
Self-citationFluoridated Hydroxyapatite Solubility and Caries Formation
Moreno, E. C., Kresak, M., & Zahradnik, R. T. (1974) · Nature · doi:10.1038/247064a0 · Cited by 347
In vitro Studies on the Effects of Fluoride on De- and Remineralization
Cate, J. M. T. (1990) · Journal of Dental Research · doi:10.1177/00220345900690s120 · Cited by 284
Influence of Fluoride in Solution on Tooth Demineralization
ten Cate, J. M., & Duijsters, P. P. E. (1983) · Caries Research · doi:10.1159/000260667 · Cited by 281
Self-citationRational Use of Fluorides in Caries Prevention: A Concept Based on Possible Cariostatic Mechanisms
Fejerskov, O., Thylstrup, A., & Larsen, M. J. (1981) · Acta Odontologica Scandinavica · doi:10.3109/00016358109162285 · Cited by 270
Physicochemical Aspects of Fluoride-Apatite Systems Relevant to the Study of Dental Caries
Moreno, E. C., Kresak, M., & Zahradnik, R. T. (2009) · Caries Research · doi:10.1159/000260299 · Cited by 251
Influence of Fluoride in Solution on Tooth Demineralization
ten Cate, J. M., & Duijsters, P. P. E. (1983) · Caries Research · doi:10.1159/000260711 · Cited by 250
Self-citationFeatherstone, J. D. B., Glena, R., Shariati, M., & Shields, C. P. (1990) · Journal of Dental Research · doi:10.1177/00220345900690s121 · Cited by 240
Self-citationThe solubility of fluorapatite and its relationship to that of calcium fluoride
McCann, H. G. (1968) · Archives of Oral Biology · doi:10.1016/0003-9969(68)90014-9 · Cited by 226
Remmeralization of Artificial Enamel Lesions in vitro
ten Cate, J. M., & Arends, J. (1977) · Caries Research · doi:10.1159/000260279 · Cited by 193
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Cited by
Oral diseases: a global public health challenge
Peres, M. A., Macpherson, L. M. D., Weyant, R. J., Daly, B., Venturelli, R., Mathur, M. R., Listl, S., Celeste, R. K., Guarnizo-Herreño, C. C., Kearns, C., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31146-8 · Cited by 4,054
Pitts, N. B., Zero, D. T., Marsh, P. D., Ekstrand, K., Weintraub, J. A., Ramos-Gomez, F., Tagami, J., Twetman, S., Tsakos, G., & Ismail, A. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.30 · Cited by 1,823
Prevention and reversal of dental caries: role of low level fluoride
Featherstone, J. D. B. (1999) · Community Dentistry and Oral Epidemiology · doi:10.1111/j.1600-0528.1999.tb01989.x · Cited by 989
Self-citationEarly childhood caries update: A review of causes, diagnoses, and treatments
Dülgergil, Ç., Dalli, M., Hamidi, M., & Çolak, H. (2013) · Journal of Natural Science, Biology and Medicine · doi:10.4103/0976-9668.107257 · Cited by 734
Mechanisms of Action of Fluoride for Caries Control
Buzalaf, M. A. R., Pessan, J. P., Honório, H. M., & ten Cate, J. M. (2011) · Monographs in Oral Science · doi:10.1159/000325151 · Cited by 554
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Metadata
- Authors
- ten Cate, J. M., & Featherstone, J. D. B.
- Venue
- Critical Reviews in Oral Biology & Medicine
- Publisher
- SAGE Publications
- Published
- 1991-07
- Volume
- 2
- Issue
- 3
- Pages
- 283-296
- ISSN
- 1045-4411 (ISSN-L)
- 1544-1113
- OpenAlex
- W1962450038
- Cited by
- 434
- References
- 52
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- ten Cate, J. M., & Featherstone, J. D. B. (1991). Mechanistic Aspects of the Interactions Between Fluoride and Dental Enamel. Critical Reviews in Oral Biology & Medicine. https://doi.org/10.1177/10454411910020030101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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