Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats.

Jayo, Manuel J.; Register, Thomas C.; Hughes, Claude L.; Blas-Machado, Uriel; Sulistiawati, Erni; Borgerink, Hermina; Johnson, Christopher S.

doi:10.1177/107155760000700411

Cited by 35Estrogen and related hormone effectsReproductive Health and ContraceptionCancer Risks and Factors

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Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats.

Jayo, Manuel J., Register, Thomas C., Hughes, Claude L., Blas-Machado, Uriel, Sulistiawati, Erni, Borgerink, Hermina, Johnson, Christopher S.·2000·Journal of the Society for Gynecologic Investigation

DOI 10.1177/107155760000700411

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Abstract

Objectives Oral contraceptive (OC) therapy has long been known to produce hypoandrogenemia. However, androgens are not part of any OC therapy available to women. This project was designed to evaluate the effects of low-estradiol containing OC, with or without methyltestosterone (MT), on cell proliferation and progesterone receptor (PgR) expression in mammary gland epithelia of virgin female rats.Methods Sixty rats were divided into four groups. One group received OCs, whereas a second group received OC plus MT. A third group of rats was treated with an antiandrogen to mimic the hypoandrogenemic effects caused by OC therapy. All treated groups were compared with age-matched untreated controls.Results After 15 weeks of treatment, no inflammatory, precancerous, or cancerous lesions were observed in any treatment group. OC plus MT therapy caused significant suppression of epithelial proliferation, a reduction in the number of proliferating cell nuclear antigen-labeled cells, and an increase in the number of PgR-labeled cells.Conclusions Our results suggest that a medication containing an estrogen-progestin-androgen combination has antiproliferative effects in mammary glands of experimental animals that could prove to have breast-protective potential in women.

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Addition of methyltestosterone inhibits the marked proliferation of mammary gland epithelium induced by a low-dose oral contraceptive in rats.
“A recent study in rats has shown that the addition of methyltestosterone inhibits the marked proliferation of the mammary gland epithelium induced by a low-dose oral contraceptive (248).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [248]

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Authors: Jayo, M. J., Register, T. C., Hughes, C. L., Blas-Machado, U., Sulistiawati, E., Borgerink, H., & Johnson, C. S.
Affiliations: Oklahoma State University (US)
Corresponding author: Jayo, Manuel J.
ORCID: Register, Thomas C.
Hughes, Claude L.
Sulistiawati, Erni
Venue: Journal of the Society for Gynecologic Investigation
Publisher: Springer Science and Business Media LLC
Published: 2000-07
Volume: 7
Issue: 4
Pages: 257-265
ISSN: 1071-5576 (ISSN-L)
DOI: 10.1177/107155760000700411
OpenAlex: W1977551520
Cited by: 35
References: 49
Citations by year: 2021: 1 · 2020: 1 · 2014: 3 · 2013: 3 · 2012: 1
FWCI: 1.55
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of the Society for Gynecologic Investigation (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords: oral contraceptives, methyltestosterone, androgens, mammary gland, epithelial cell proliferation, progesterone receptor, proliferating cell nuclear antigen, androgen receptor antagonists, breast cancer prevention, rats
MeSH terms: Androgens, Animals, Body Weight, Cell Count, Cell Division, Contraceptives, Oral, Combined, Eating, Epithelial Cells, Estradiol, Estrogens, Ethinyl Estradiol, Female, Mammary Glands, Animal, Progestins, Receptors, Progesterone, Testosterone, Rats, Sprague-Dawley, Proliferating Cell Nuclear Antigen, Rats

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Effects of an oral contraceptive combination with or without androgen on mammary tissues: a study in rats.

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