The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Functional imaging and pain: behavior, perception, and modulation.
Open accessAbstract
Time-dependent increases of local metabolic or blood flow rates have been described in spinal cord and brain during acute and chronic pain states in experimental animals, in parallel with changes of different behavioral endpoints of pain and hyperalgesia. In healthy human volunteers, pain intensity-related hemodynamic changes have been identified in a widespread, bilateral brain system including parietal, insular, cingulate, and frontal cortical areas, as well as thalamus, amygdala, and midbrain. Specific patterns of activity may characterize hyperalgesic states and some chronic pain conditions. Forebrain nociceptive systems are under inhibitory control by endogenous opioids and can be affected by acute administration of mu-opioid receptor agonists. Anticipation of pain may in itself induce changes in brain nociceptive networks. Moreover, pain-related cortical activity can be modulated by hypnotic suggestions, focusing or diverting attention, and placebo. These findings begin to disclose the spatio-temporal dynamics of brain networks underlying pain perception and modulation.
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“Taken together, the results of fMRI experiment I replicate and extend previous findings concerning empathy for pain by showing a stronger involvement of neural structures involved in action anticipation and somatosensation when focusing on the sensory consequences of mechanically induced pain [34], [54], [55].”
From What are you feeling? Using functional magnetic resonance imaging to assess the modulation of sensory and affective responses during empathy for pain (2007) · cites this paper as [54]
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Legrain, V., Iannetti, G. D., Plaghki, L., & Mouraux, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.005 · Cited by 854
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Metadata
- Authors
- Porro, C. A.
- Affiliations
- University of Udine (IT)
- Corresponding author
- Porro, Carlo A.
- ORCID
- Porro, Carlo A.
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2003-10
- Volume
- 9
- Issue
- 5
- Pages
- 354-369
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2136606402
- Cited by
- 132
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 12 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- pain perception, chronic pain, hyperalgesia, brain imaging of pain, hemodynamic changes, endogenous opioids, mu-opioid receptor agonists, pain anticipation, hypnotic suggestion, attentional modulation, placebo effect, pain modulation
- MeSH terms
- Animals, Brain, Diagnostic Imaging, Humans, Pain, Pain Measurement, Perception
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