From the neuromatrix to the pain matrix (and back)

Iannetti, G. D.; Mouraux, A.

doi:10.1007/s00221-010-2340-1

Cited by 554Pain Mechanisms and TreatmentsPain Management and TreatmentPain Management and Placebo Effect

From the neuromatrix to the pain matrix (and back)

Iannetti, G. D., Mouraux, A.·2010·Experimental Brain Research

DOI 10.1007/s00221-010-2340-1

Open this paper in CoChat — free account

Abstract

Pain is a conscious experience, crucial for survival. To investigate the neural basis of pain perception in humans, a large number of investigators apply noxious stimuli to the body of volunteers while sampling brain activity using different functional neuroimaging techniques. These responses have been shown to originate from an extensive network of brain regions, which has been christened the Pain Matrix and is often considered to represent a unique cerebral signature for pain perception. As a consequence, the Pain Matrix is often used to understand the neural mechanisms of pain in health and disease. Because the interpretation of a great number of experimental studies relies on the assumption that the brain responses elicited by nociceptive stimuli reflect the activity of a cortical network that is at least partially specific for pain, it appears crucial to ascertain whether this notion is supported by unequivocal experimental evidence. Here, we will review the original concept of the "Neuromatrix" as it was initially proposed by Melzack and its subsequent transformation into a pain-specific matrix. Through a critical discussion of the evidence in favor and against this concept of pain specificity, we show that the fraction of the neuronal activity measured using currently available macroscopic functional neuroimaging techniques (e.g., EEG, MEG, fMRI, PET) in response to transient nociceptive stimulation is likely to be largely unspecific for nociception.

Integrity signals

Registry

Crossref · 10.1007/s00221-010-2340-1

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The cortical processes generating LEPs are largely related to the perception of salient changes in the sensory environment and contribute to the perception of pain.
“the cortical processes generating LEPs are largely related to the perception of salient changes in the sensory environment 59, 60, and contribute to the perception of pain 61, 62.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [62]

Principles of neural science
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,148 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
Receptive fields and functional architecture of monkey striate cortex
Hubel, D. H., & Wiesel, T. N. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008455 · Cited by 6,520 · see citing works
Computational modelling of visual attention
Itti, L., & Koch, C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35058500 · Cited by 4,733 · see citing works
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., & Turner, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5675 · Cited by 4,212 · see citing works
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929 · see citing works
Does Rejection Hurt? An fMRI Study of Social Exclusion
Eisenberger, N. I., Lieberman, M. D., & Williams, K. D. (2003) · Science · doi:10.1126/science.1089134 · Cited by 3,849 · see citing works
What we can do and what we cannot do with fMRI
Logothetis, N. K. (2008) · Nature · doi:10.1038/nature06976 · Cited by 3,612 · see citing works
PRINCIPLES OF NEURAL SCIENCE
Henry, M. A. (1995) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1995.0108 · Cited by 3,454 · see citing works
The N1 wave of the human electric and magnetic response to sound: A review and an analysis of the component structure
Näätänen, R., & Picton, T. (1987) · Psychophysiology · doi:10.1111/j.1469-8986.1987.tb00311.x · Cited by 3,321 · see citing works
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126 · see citing works
From sensation to cognition
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072 · see citing works
Probabilistic Independent Component Analysis for Functional Magnetic Resonance Imaging
Beckmann, C. F., & Smith, S. M. (2004) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2003.822821 · Cited by 2,707 · see citing works
The mismatch negativity (MMN) in basic research of central auditory processing: A review
Näätänen, R., Paavilainen, P., Rinne, T., & Alho, K. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.04.026 · Cited by 2,644 · see citing works
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629 · see citing works
Textbook of pain
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,533 · see citing works
MODALITY AND TOPOGRAPHIC PROPERTIES OF SINGLE NEURONS OF CAT'S SOMATIC SENSORY CORTEX
Mountcastle, V. B. (1957) · Journal of Neurophysiology · doi:10.1152/jn.1957.20.4.408 · Cited by 2,411 · see citing works
Sensory disturbances from cerebral lesions
HEAD, H., & HOLMES, G. (1911) · Brain · doi:10.1093/brain/34.2-3.102 · Cited by 1,852 · see citing works
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843 · see citing works
Electroencephalography: Basic Principles, Clinical Applications and Related Fields
Torres, F. (1983) · Archives of Neurology · doi:10.1001/archneur.1983.04050030085025 · Cited by 1,825 · see citing works
How do we perceive the pain of others? A window into the neural processes involved in empathy
Jackson, P. L., Meltzoff, A. N., & Decety, J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.09.006 · Cited by 1,257 · see citing works
Dissociating pain from its anticipation in the human brain
Ploghaus, A., Tracey, I., Gati, J. S., Clare, S., Menon, R. S., Matthews, P. M., & Rawlins, J. N. P. (1999) · Science · doi:10.1126/science.284.5422.1979 · Cited by 1,151 · see citing works
The cortical representation of pain
Treede, R.-D., Kenshalo, D. R., Gracely, R. H., & Jones, A. K. P. (1999) · Pain · doi:10.1016/s0304-3959(98)00184-5 · Cited by 1,077 · see citing works
Pain intensity processing within the human brain: a bilateral, distributed mechanism
Coghill, R. C., Sang, C. N., Maisog, J. M., & Iadarola, M. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.1934 · Cited by 1,077 · see citing works
Fundamental Components of Attention
Knudsen, E. I. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094256 · Cited by 1,020 · see citing works
Thermosensory activation of insular cortex
Craig, A. D., Chen, K., Bandy, D., & Reiman, E. M. (2000) · Nature Neuroscience · doi:10.1038/72131 · Cited by 1,004 · see citing works
Multiple Representations of Pain in Human Cerebral Cortex
Talbot, J. D., Marrett, S., Evans, A. C., Meyer, E., Bushnell, M. C., & Duncan, G. H. (1991) · Science · doi:10.1126/science.2003220 · Cited by 969 · see citing works
A multimodal cortical network for the detection of changes in the sensory environment
Downar, J., Crawley, A. P., Mikulis, D. J., & Davis, K. D. (2000) · Nature Neuroscience · doi:10.1038/72991 · Cited by 947 · see citing works
Salience, relevance, and firing: a priority map for target selection
Fecteau, J. H., & Muñoz, D. G. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.06.011 · Cited by 912 · see citing works
Pain catastrophizing and neural responses to pain among persons with fibromyalgia
Gracely, R. H. (2004) · Brain · doi:10.1093/brain/awh098 · Cited by 892 · see citing works
P AIN M ECHANISMS : Labeled Lines Versus Convergence in Central Processing
Craig, A. D. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131022 · Cited by 749 · see citing works
Pain-related neurons in the human cingulate cortex
Hutchison, W. D., Davis, K. D., Lozano, A. M., Tasker, R. R., & Dostrovsky, J. O. (1999) · Nature Neuroscience · doi:10.1038/8065 · Cited by 681 · see citing works
Brain mechanisms of pain affect and pain modulation
Rainville, P. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00313-6 · Cited by 634 · see citing works
Pain processing during three levels of noxious stimulation produces differential patterns of central activity
Derbyshire, S. W. G., Jones, A. K. P., Gyulai, F., Clark, S., Townsend, D., & Firestone, L. L. (1997) · Pain · doi:10.1016/s0304-3959(97)00138-3 · Cited by 629 · see citing works
Transcranial magnetic stimulation highlights the sensorimotor side of empathy for pain.
Avenanti, A., Bueti, D., Galati, G., & Aglioti, S. M. (2005) · Nature Neuroscience · doi:10.1038/nn1481 · Cited by 615 · see citing works
A thalamic nucleus specific for pain and temperature sensation
Craig, A. D., Bushnell, M. C., Zhang, E.-T., & Blomqvist, A. G. (1994) · Nature · doi:10.1038/372770a0 · Cited by 614 · see citing works
Cortical Representation of the Sensory Dimension of Pain
Hofbauer, R. K., Rainville, P., Duncan, G. H., & Bushnell, M. C. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.402 · Cited by 611 · cited 14× · see citing works
“A conjunction analysis showed that nociceptive, somatosensory, auditory and visual stimuli elicited spatially indistinguishable responses in the insula, in most of S2, as well as in the ACC.”
BackgroundInfluential
Pain “relief” by frontal cingulumotomy
Foltz, E. L., & White, L. E. (1962) · Journal of Neurosurgery · doi:10.3171/jns.1962.19.2.0089 · Cited by 588 · see citing works
Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: A single-trial fMRI study
Bornhövd, K., Quante, M., Glauche, V., Bromm, B., Weiller, C., & Büchel, C. (2002) · Brain · doi:10.1093/brain/awf137 · Cited by 584 · see citing works
Representation of Pain and Somatic Sensation in the Human Insula: a Study of Responses to Direct Electrical Cortical Stimulation
Ostrowsky‐Coste, K. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.376 · Cited by 573 · see citing works
A multisensory investigation of the functional significance of the “pain matrix”
Mouraux, A., Diukova, A., Lee, M., Wise, R. G., & Iannetti, G. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.084 · Cited by 556 · see citing works
Self-citation
Brain generators of laser-evoked potentials: from dipoles to functional significance
Garcia-Larrea, L., Frot, M., & Valeriani, M. (2003) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/j.neucli.2003.10.008 · Cited by 541 · see citing works
Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study
Isnard, J., Guénot, M., Sindou, M., & Mauguière, F. (2004) · Epilepsia · doi:10.1111/j.0013-9580.2004.68903.x · Cited by 504 · see citing works
Viewpoint: the core and matrix of thalamic organization
Jones, E. G. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00581-2 · Cited by 504 · see citing works
A neurocognitive model of attention to pain: Behavioral and neuroimaging evidence
Legrain, V., Damme, S. V., Eccleston, C., Davis, K. D., Seminowicz, D. A., & Crombez, G. (2009) · Pain · doi:10.1016/j.pain.2009.03.020 · Cited by 480 · see citing works
Expertise modulates the perception of pain in others
Cheng, Y., Lin, C.-P., Liu, H.-L., Hsu, Y.-Y., Lim, K.-E., Hung, D., & Decety, J. (2007) · Current Biology · doi:10.1016/j.cub.2007.09.020 · Cited by 477 · see citing works
Perception of pain in the minimally conscious state with PET activation: an observational study
Boly, M., Faymonville, M.-É., Caroline Schnakers, A., Peigneux, P., Lambermont, B. C., Phillips, C. L. M., Lancellotti, P., Luxen, A., Lamy, M., Moonen, G., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70219-9 · Cited by 421 · see citing works
Diencephalic mechanisms of pain sensation
Albe-Fessard, D., Berkley, K. J., Kruger, L., Ralston, H. J., & Willis, W. D. (1985) · Brain Research Reviews · doi:10.1016/0165-0173(85)90013-x · Cited by 407 · see citing works
Determinants of Laser-Evoked EEG Responses: Pain Perception or Stimulus Saliency?
Iannetti, G. D., Hughes, N. P., Lee, M., & Mouraux, A. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00097.2008 · Cited by 400 · see citing works
Self-citation
Keeping pain in mind: A motivational account of attention to pain
Damme, S. V., Legrain, V., Vogt, J., & Crombez, G. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.005 · Cited by 399 · see citing works
Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study.
Büchel, C., Bornhövd, K., Quante, M., Glauche, V., Bromm, B., & Weiller, C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00970.2002 · Cited by 380 · see citing works
REVIEW: From nociception to pain perception: imaging the spinal and supraspinal pathways
Brooks, J. C. W., & Tracey, I. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00428.x · Cited by 377 · see citing works
The Spinothalamic System Targets Motor and Sensory Areas in the Cerebral Cortex of Monkeys
Dum, R. P., Levinthal, D. J., & Strick, P. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3398-09.2009 · Cited by 377 · see citing works
Nociceptive Laser-Evoked Brain Potentials Do Not Reflect Nociceptive-Specific Neural Activity
Mouraux, A., & Iannetti, G. D. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91181.2008 · Cited by 373 · see citing works
Self-citation
Nociceptive neurons in area 24 of rabbit cingulate cortex
Sikes, R. W., & Vogt, B. A. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.5.1720 · Cited by 368 · see citing works
Neurophysiology and Functional Neuroanatomy of Pain Perception
Schnitzler, A., & Ploner, M. (2000) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200011000-00005 · Cited by 350 · see citing works
Responses of primate SI cortical neurons to noxious stimuli
Kenshalo, D. R., & Isensee, O. (1983) · Journal of Neurophysiology · doi:10.1152/jn.1983.50.6.1479 · Cited by 350 · see citing works
A review of the evidence
Giedión, Ú., & Díaz, Y. (2010) · Brookings Institution Press eBooks · Cited by 349 · see citing works
Thalamic circuitry and thalamocortical synchrony
Jones, E. G. (2002) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1168 · Cited by 340 · see citing works
Evolution of the Neuromatrix Theory of Pain. The Prithvi Raj Lecture: Presented at the Third World Congress of World Institute of Pain, Barcelona 2004
Melzack, R. (2005) · Pain Practice · doi:10.1111/j.1533-2500.2005.05203.x · Cited by 339 · see citing works
Brain imaging of neuropathic pain
Moisset, X., & Bouhassira, D. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.054 · Cited by 338 · see citing works
Persistent EEG overactivation in the cortical pain matrix of neurogenic pain patients
Stern, J., Jeanmonod, D., & Sarnthein, J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.042 · Cited by 334 · see citing works
RESPONSE PROPERTIES OF NEURONS OF CAT'S SOMATIC SENSORY CORTEX TO PERIPHERAL STIMULI
Mountcastle, V. B., Davies, P. W., & Berman, A. L. (1957) · Journal of Neurophysiology · doi:10.1152/jn.1957.20.4.374 · Cited by 332 · see citing works
Mechanisms for Allocating Auditory Attention: An Auditory Saliency Map
Kayser, C., Petkov, C. I., Lippert, M., & Logothetis, N. K. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.040 · Cited by 316 · see citing works
Binaural columns in the primary field (A1) of cat auditory cortex
Imig, T. J., & ́n, H. O. A. (1977) · Brain Research · doi:10.1016/0006-8993(77)90743-0 · Cited by 307 · see citing works
Neuronal Mechanisms of the Orienting Reflex
Stern, J. A. (1976) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-197611000-00016 · Cited by 307 · see citing works
Symmetry and connectivity in the map of the body surface in somatosensory area II of primates.
Whitsel, B. L., Petrucelli, L., & Werner, G. R. (1969) · Journal of Neurophysiology · doi:10.1152/jn.1969.32.2.170 · Cited by 303 · see citing works
Association and dissociation between laser-evoked potentials and pain perception
Garcí-Larrea, L., Peyron, R., Laurent, B., & Mauguière, F. (1997) · NeuroReport · doi:10.1097/00001756-199712010-00026 · Cited by 298 · see citing works
Pain sensitivity alterations as a function of lesion location in the parasylvian cortex
Greenspan, J. D., Lee, R. R., & Lenz, F. A. (1999) · Pain · doi:10.1016/s0304-3959(99)00021-4 · Cited by 297 · see citing works
Roles of the Insular Cortex in the Modulation of Pain: Insights from Brain Lesions
Starr, C. J., Sawaki, L. A., Wittenberg, G. F., Burdette, J. H., Oshiro, Y., de Quevedo, A. S., & Coghill, R. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5173-08.2009 · Cited by 283 · see citing works
Somatotopographic organization in the second somatosensory area of M. fascicularis
Robinson, C. J., & Burton, H. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901920104 · Cited by 280 · see citing works
Nociceptive processing in the human brain
Tracey, I. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.06.010 · Cited by 278 · see citing works
Pain and functional imaging
Ingvar, M. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0483 · Cited by 277 · see citing works
Attentional modulation of the nociceptive processing into the human brain: selective spatial attention, probability of stimulus occurrence, and target detection effects on laser evoked potentials
Legrain, V., Guérit, J.-M., Bruyer, R., & Plaghki, L. (2002) · Pain · doi:10.1016/s0304-3959(02)00051-9 · Cited by 274 · see citing works
Differential Coding of Pain Intensity in the Human Primary and Secondary Somatosensory Cortex
Timmermann, L., Ploner, M., Haucke, K., Schmitz, F., Baltissen, R., & Schnitzler, A. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.3.1499 · Cited by 270 · see citing works
Phantom limbs, the self and the brain: The D.O. Hebb memorial lecture
Melzack, R. (1989) · Canadian Psychology / Psychologie canadienne · doi:10.1037/h0079793 · Cited by 260 · see citing works
Variability of laser-evoked potentials: attention, arousal and lateralized differences
Beydoun, A. A., Morrow, T. J., Shen, J. F., & Casey, K. L. (1993) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(93)90002-7 · Cited by 259 · see citing works
Temporal and Intensity Coding of Pain in Human Cortex
Porro, C. A., Cettolo, V., Francescato, M. P., & Baraldi, P. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.3312 · Cited by 253 · see citing works
Evoked cerebral responses to noxious thermal stimuli in humans
Carmon, A., Mor, J., & Goldberg, J. L. (1976) · Experimental Brain Research · doi:10.1007/bf00237330 · Cited by 251 · see citing works
Cortical representation of first and second pain sensation in humans
Ploner, M., Groß, J., Timmermann, L., & Schnitzler, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182272899 · Cited by 226 · see citing works
Operculoinsular cortex encodes pain intensity at the earliest stages of cortical processing as indicated by amplitude of laser-evoked potentials in humans
Iannetti, G. D., Zambreanu, L., Cruccu, G., & Tracey, I. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.035 · Cited by 222 · see citing works
Self-citation
Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked pain
Garcı́a-Larrea, L. (2002) · Brain · doi:10.1093/brain/awf275 · Cited by 222 · see citing works
Somatosensory, multisensory, and task-related neurons in cortical area 7b (PF) of unanesthetized monkeys
Dong, W. K., Chudler, E. H., Sugiyama, K., Roberts, V. J., & Hayashi, T. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.2.542 · Cited by 212 · see citing works
Human SII and Posterior Insula Differently Encode Thermal Laser Stimuli
Frot, M., Magnin, M., Mauguı̀ere, F., & Garcı́a-Larrea, L. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk007 · Cited by 205 · see citing works
Neural correlates of the prolonged salience of painful stimulation
Downar, J. H., Mikulis, D. J., & Davis, K. D. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00407-5 · Cited by 200 · see citing works
Non-phase locked electroencephalogram (EEG) responses to CO2 laser skin stimulations may reflect central interactions between A∂- and C-fibre afferent volleys
Mouraux, A., Guérit, J., & Plaghki, L. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00027-0 · Cited by 194 · see citing works
Self-citation
Human cerebral potentials evoked by CO2 laser stimuli causing pain
Bromm, B., & Treede, R. (1987) · Experimental Brain Research · doi:10.1007/bf00269463 · Cited by 192 · see citing works
Response Properties and Organization of Nociceptive Neurons in Area 1 of Monkey Primary Somatosensory Cortex
Kenshalo, D. R., Iwata, K., Sholas, M., & Thomas, D. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.2.719 · Cited by 184 · see citing works
Correlation of subjective pain experience with cerebral evoked responses to noxious thermal stimulations
Carmon, A., Dotan, Y., & Sarne, Y. (1978) · Experimental Brain Research · doi:10.1007/bf00235566 · Cited by 183 · see citing works
The Neural Basis of Selective Attention
Yantis, S. (2008) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2008.00554.x · Cited by 172 · see citing works
Characterizing the Cortical Activity through Which Pain Emerges from Nociception
Lee, M. C., Mouraux, A., & Iannetti, G. D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0014-09.2009 · Cited by 169 · see citing works
Self-citation
Reversible pain and tactile deficits associated with a cerebral tumor compressing the posterior insula and parietal operculum
Greenspan, J. D., & Winfield, J. A. (1992) · Pain · doi:10.1016/0304-3959(92)90109-o · Cited by 165 · see citing works
Les passions de l'âme
Descartes, R., & Rodis-Lewis, G. (1996) · Cited by 163 · see citing works
Stereotactic Anterior Cingulate Lesions for Persistent Pain: A Report on 68 Cases
Hurt, W. R., & Ballantine, T. H. (1974) · Neurosurgery · doi:10.1093/neurosurgery/21.cn_suppl_1.334 · Cited by 155 · see citing works
Emotional Modulation of Pain: Is It the Sensation or What We Recall?
Godinho, F. L. F., Magnin, M., Frot, M., Perchet, C., & Garcı́a-Larrea, L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2260-06.2006 · Cited by 155 · see citing works
Topography of middle-latency somatosensory evoked potentials following painful laser stimuli and non-painful electrical stimuli
Kunde, V., & Treede, R. (1993) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0168-5597(93)90052-q · Cited by 154 · see citing works
Parallel Processing of Nociceptive A-δ Inputs in SII and Midcingulate Cortex in Humans
Frot, M., Mauguı̀ere, F., Magnin, M., & Garcı́a-Larrea, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2934-07.2008 · Cited by 148 · see citing works
Mechanisms of pain relief by vibration and movement.
Kakigi, R., & Shibasaki, H. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.4.282 · Cited by 147 · see citing works
PAINFUL EPILEPTIC SEIZURES
Young, G. B., & Blume, W. T. (1983) · Brain · doi:10.1093/brain/106.3.537 · Cited by 139 · see citing works
Morphological and electrophysiological properties of ACCx nociceptive neurons in rats
Yamamura, H., Iwata, K., Tsuboi, Y., Toda, K., Kitajima, K., Shimizu, N., Nomura, H., Hibiya, J., Fujita, S., & Sumino, R. (1996) · Brain Research · doi:10.1016/0006-8993(96)00561-6 · Cited by 137 · see citing works
Neurobiology of schizophrenia
Pearlson, G. D. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200010)48:4 · Cited by 133 · see citing works
Functional imaging and pain: behavior, perception, and modulation.
Porro, C. A. (2003) · The Neuroscientist · doi:10.1177/1073858403253660 · Cited by 132 · see citing works
First come, first served
Zeller, R., & Deschamps, J. (2002) · Nature · doi:10.1038/420138a · Cited by 126 · see citing works
SOMATOSENSORY EPILEPSY
Mauguı̀ere, F., & Courjon, J. (1978) · Brain · doi:10.1093/brain/101.2.307 · Cited by 120 · see citing works
Amplitudes of laser evoked potential recorded from primary somatosensory, parasylvian and medial frontal cortex are graded with stimulus intensity
Ohara, S., Crone, E., Weiss, N., Treede, R., & Lenz, A. F. (2004) · Pain · doi:10.1016/j.pain.2004.04.009 · Cited by 118 · see citing works
Seeing the pain of others while being in pain: A laser-evoked potentials study
Valeriani, M., Betti, V., Pera, D. L., Armas, L. D., Miliucci, R., Restuccia, D., Avenanti, A., & Aglioti, S. M. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.12.056 · Cited by 117 · see citing works
Involuntary Orienting of Attention to Nociceptive Events: Neural and Behavioral Signatures
Legrain, V., Perchet, C., & Garcı́a-Larrea, L. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00372.2009 · Cited by 112 · see citing works
Heterotopic nociceptive conditioning stimuli and mental task modulate differently the perception and physiological correlates of short CO2 laser stimuli
Plaghki, L., Delisle, D., & Godfraind, J. (1994) · Pain · doi:10.1016/0304-3959(94)90222-4 · Cited by 110 · see citing works
The role of rostral cingulumotomy in "pain" relief.
Foltz, E. L., & White, L. E. (1968) · PubMed · Cited by 109 · see citing works
The organization of sensory cortex
Kaas, J. H. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00240-3 · Cited by 103 · see citing works
Evoked responses of human auditory cortex may be enhanced by preceding stimuli
Loveless, N. E., Hari, R., Ha¨ma¨la¨inen, M., et al. (1989) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/0013-4694(89)90008-4 · Cited by 98 · see citing works
Pain and the brain : from nociception to cognition
Bromm, B., & Desmedt, J. E. (1995) · Cited by 93 · see citing works
Characteristics, detection, and modulation of laser‐evoked vertex potentials
Arendt‐Nielsen, L. (1994) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1994.tb04027.x · Cited by 92 · see citing works
The Enhancement of the N1 Wave Elicited by Sensory Stimuli Presented at Very Short Inter-Stimulus Intervals Is a General Feature across Sensory Systems
Wang, A. L., Mouraux, A., Liang, M., & Iannetti, G. D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003929 · Cited by 86 · see citing works
Self-citation
Touch or pain? Spatio-temporal patterns of cortical fMRI activity following brief mechanical stimuli
Lui, F., Duzzi, D., Corradini, M., Serafini, M., Baraldi, P., & Porro, C. A. (2008) · Pain · doi:10.1016/j.pain.2008.01.010 · Cited by 86 · see citing works
Rate of stimulus repetition changes evoked potential amplitude: Dental and auditory modalities compared
Colpitts, Y. H., Mayeno, J. K., & Gagliardi, G. J. (1981) · Experimental Brain Research · doi:10.1007/bf00238365 · Cited by 81 · see citing works
Facilitation of the N1 peak of the auditory ERP at short stimulus intervals
Budd, T. W., & Michie, P. T. (1994) · Neuroreport · doi:10.1097/00001756-199412000-00027 · Cited by 78 · see citing works
Stimulus Novelty, and Not Neural Refractoriness, Explains the Repetition Suppression of Laser-Evoked Potentials
Wang, A. L., Mouraux, A., Liang, M., & Iannetti, G. D. (2010) · Journal of Neurophysiology · doi:10.1152/jn.01088.2009 · Cited by 71 · see citing works
Self-citation
[Behavioral manifestations induced by electric stimulation of the anterior cingulate gyrus in man].
Bancaud, J., Talairach, J., Geier, S., et al. (1976) · PubMed · Cited by 71 · see citing works
Inhibition of cortical responses to Aδ inputs by a preceding C-related response: Testing the “first come, first served” hypothesis of cortical laser evoked potentials
Truini, A., Galeotti, F., Cruccu, G., & Garcı́a-Larrea, L. (2007) · Pain · doi:10.1016/j.pain.2007.06.023 · Cited by 60 · see citing works
Pharmacological FMRI in the development of new analgesic compounds
Schweinhardt, P., Bountra, C., & Tracey, I. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1076 · Cited by 59 · see citing works
Electrophysiological correlates of attentional orientation in humans to strong intensity deviant nociceptive stimuli, inside and outside the focus of spatial attention
Legrain, V., Guérit, J., Bruyer, R., & Plaghki, L. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01485-4 · Cited by 56 · see citing works
Effects of Interstimulus Interval on Cortical Responses to Painful Laser Stimulation
Raij, T. T., Vartiainen, N. V., Jousmäki, V., & Hari, R. (2003) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200302000-00010 · Cited by 54 · see citing works
Dissociating nociceptive modulation by the duration of pain anticipation from unpredictability in the timing of pain
Clark, J. A., Brown, C. A., Jones, A. K. P., & El‐Deredy, W. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.09.022 · Cited by 53 · see citing works
Cortical interactions and integration of nociceptive and non-nociceptive somatosensory inputs in humans
Mouraux, A., & Plaghki, L. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.08.035 · Cited by 52 · see citing works
Self-citation
Pain and the Brain from Nociception to Cognition
Schwartzman, R. J. (1996) · Neurosurgery · doi:10.1097/00006123-199606000-00053 · Cited by 51 · see citing works
Event related brain potentials and human pain: A first objective overview
Stowell, H. (1984) · International Journal of Psychophysiology · doi:10.1016/0167-8760(84)90034-5 · Cited by 47 · see citing works
Refractoriness cannot explain why C-fiber laser-evoked brain potentials are recorded only if concomitant Aδ-fiber activation is avoided
Mouraux, A., Guérit, J., & Plaghki, L. (2004) · Pain · doi:10.1016/j.pain.2004.05.024 · Cited by 47 · see citing works
Self-citation
The influence of semantic priming on event-related potentials to painful laser-heat stimuli in humans
Dillmann, J., Miltner, W. H. R., & Weiss, T. F. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00957-5 · Cited by 46 · see citing works
Subjective estimates of chronic pain before and after psychosurgery or treatment in a pain unit
Corkin, S., & Hebben, N. (1981) · Pain · doi:10.1016/0304-3959(81)90390-0 · Cited by 38 · see citing works
Excitability of the Aδ nociceptive pathways as assessed by the recovery cycle of laser evoked potentials in humans
Truini, A., Rossi, P., Galeotti, F., Romaniello, A., Virtuoso, M., de Lena, C., Leandri, M., & Cruccu, G. (2004) · Experimental Brain Research · doi:10.1007/s00221-003-1785-x · Cited by 38 · see citing works
Chapter 1 Pain and hyperalgesia: definitions and theories
Treede, R. (2006) · Handbook of clinical neurology · doi:10.1016/s0072-9752(06)80005-9 · Cited by 36 · see citing works
Area 3a Neuron Response to Skin Nociceptor Afferent Drive
Whitsel, B. L., Favorov, O. V., Li, Y., et al. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn086 · Cited by 36 · see citing works
Human brain processing and central mechanisms of pain as observed by electro- and magneto-encephalography.
Kakigi, R., Inui, K., Tran, D. T., Qiu, Y., Wang, X., Watanabe, S., & Hoshiyama, M. (2004) · PubMed · Cited by 36 · see citing works
Sensory Decision Theory Describes Evoked Potentials in Pain Discrimination
Chapman, C. R., Chen, A. C. N., Colpitts, Y. H., et al. (1981) · Psychophysiology · doi:10.1111/j.1469-8986.1981.tb02923.x · Cited by 34 · see citing works
Modulation of perception and neurophysiological correlates of brief CO2laser stimuli in humans using concurrent large fiber stimulation
Nahra, H., & Plaghki, L. (2003) · Somatosensory & Motor Research · doi:10.1080/0899022031000105172 · Cited by 30 · see citing works
The pain matrix and neuropathic pain
Jones, A. (1998) · Brain · doi:10.1093/brain/121.5.783 · Cited by 29 · see citing works
Brain Scans of Pain Raise Questions for the Law
Miller, G. (2009) · Science · doi:10.1126/science.323.5911.195 · Cited by 28 · see citing works
Independent mechanisms converge on pain
Wall, P. D. (1995) · Nature Medicine · doi:10.1038/nm0895-740 · Cited by 20 · see citing works
A review of the evidence against the “first come first served” hypothesis. Comment on Truini et al. [Pain 2007;131:43–7]
Mouraux, A., & Iannetti, G. D. (2008) · Pain · doi:10.1016/j.pain.2008.02.010 · Cited by 17 · see citing works
Self-citation
Clinical implications of the integrity of the pain matrix
Whyte, J. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70220-5 · Cited by 17 · see citing works
Acute, localised paroxysmal pain as the initial manifestation of focal seizures: A case report and a brief review of the literature
Charlesworth, G., Soryal, I., Smith, S. J. M., & Sisodiya, S. M. (2009) · Pain · doi:10.1016/j.pain.2008.11.005 · Cited by 15 · see citing works
Cortical nociceptive systems
Andersson, S. A., & Rydenhag, B. (1985) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1985.0035 · Cited by 6 · see citing works
Increased activity of surviving locus ceruleus neurons in Alzheimer's disease
Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1

Flagged first, then by citations

Sorted by citations

Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits
Hashmi, J. A., Baliki, M. N., Huang, L., Baria, A. T., Torbey, S., Hermann, K. M., Schnitzer, T. J., & Apkarian, A. V. (2013) · Brain · doi:10.1093/brain/awt211 · Cited by 762 · see citing works
Nociception, pain, negative moods, and behavior selection
Baliki, M. N., & Apkarian, A. V. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.005 · Cited by 731 · see citing works
The dynamic pain connectome
Kucyi, A., & Davis, K. D. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.006 · Cited by 587 · see citing works
Putting together phylogenetic and ontogenetic perspectives on empathy
Decety, J., & Svetlova, M. (2012) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.05.003 · Cited by 508 · see citing works
Why fish do not feel pain
Key, B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1011 · Cited by 318 · see citing works
Insects have the capacity for subjective experience
Klein, C., & Barron, A. B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1113 · Cited by 243 · see citing works
Spatial Sensory Organization and Body Representation in Pain Perception
Haggard, P., Iannetti, G. D., & Longo, M. R. (2013) · Current Biology · doi:10.1016/j.cub.2013.01.047 · Cited by 192 · see citing works
Self-citation
Beyond metaphor: Contrasting mechanisms of social and physical pain
Iannetti, G. D., Salomons, T. V., Moayedi, M., Mouraux, A., & Davis, K. D. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.06.002 · Cited by 166 · see citing works
Self-citation
Preserved emotional awareness of pain in a patient with extensive bilateral damage to the insula, anterior cingulate, and amygdala
Feinstein, J. S., Khalsa, S. S., Salomons, T. V., Prkachin, K. M., Frey-Law, L. A., Lee, J. E., Tranel, D., & Rudrauf, D. (2016) · Brain Structure and Function · doi:10.1007/s00429-014-0986-3 · Cited by 108 · see citing works
The interaction of emotion and pain in the insula and secondary somatosensory cortex.
Orenius, T. I., Raij, T. T., Nuortimo, A., Näätänen, P., Lipsanen, J., & Karlsson, H. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.02.047 · Cited by 94 · see citing works
Empathy for social exclusion involves the sensory-discriminative component of pain: a within-subject fMRI study
Novembre, G., Zanon, M., & Silani, G. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu038 · Cited by 92 · see citing works
The opioid system and the social brain: implications for depression and suicide
Lutz, P., Courtet, P., & Calati, R. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24269 · Cited by 53 · see citing works
The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials
Paloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12347 · Cited by 61 · see citing works
Size and viewpoint of an embodied virtual body affect the processing of painful stimuli
Romano, D., Llobera, J., & Blanke, O. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2015.11.005 · Cited by 53 · see citing works
Dishabituation of laser-evoked EEG responses: dissecting the effect of certain and uncertain changes in stimulus spatial location
Torta, D. M., Liang, M., Valentini, E., Mouraux, A., & Iannetti, G. D. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3019-6 · Cited by 41 · see citing works
Self-citation
Altered Neural Activity Associated with Mindfulness during Nociception: a Systematic Review of Functional MRI.
Bilevicius, E., Kolesar, T., & Kornelsen, J. (2016) · Brain Sciences · doi:10.3390/brainsci6020014 · Cited by 22 · see citing works
Are infants conscious?
Passos‐Ferreira, C. (2023) · Philosophical Perspectives · doi:10.1111/phpe.12192 · Cited by 46 · see citing works
Pain modulation in waking and hypnosis in women: event-related potentials and sources of cortical activity
De Pascalis, V., Varriale, V., & Cacace, I. (2015) · PLOS ONE · doi:10.1371/journal.pone.0128474 · Cited by 20 · see citing works
Thalamocortical bistable switch as a theoretical model of fibromyalgia pathogenesis inferred from a literature survey
Demori, I., Giordano, G., Mucci, V., Losacco, S., Marinelli, L., Massobrio, P., Blanchini, F., & Burlando, B. (2022) · Journal of Computational Neuroscience · doi:10.1007/s10827-022-00826-8 · Cited by 14 · see citing works
The Role of the Environment in Eliciting Phantom-Like Sensations in Non-Amputees
Lewis, E., Lloyd, D. M., & Farrell, M. J. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00600 · Cited by 12 · see citing works

Development of thermal nociception in rats
Falcon, M., Guendellman, D., Stolberg, A., Frenk, H., & Urca, G. (1996) · Pain · doi:10.1016/0304-3959(96)03070-9 · Cited by 74 · see citing works
First Demonstration of Nociceptive and Non-Nociceptive Responses from Spinal Neurons in a Porcine Model
Meijs, S., Bjarkam, C. R., Andreis, F. R., et al. (2023) · International IEEE/EMBS Conference on Neural Engineering · doi:10.1109/ner52421.2023.10123833 · Cited by 2 · see citing works
Pain in a Balance: Noxious Events Engage Opposing Processes That Concurrently Modulate Nociceptive Reactivity.
Crown, E. D., Grau, J. W., & Meagher, M. W. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.6.1418 · Cited by 16 · see citing works
Periaqueductal grey mediated inhibition of responses to noxious stimulation is dynamically activated in a rat model of neuropathic pain
Monhemius, R., Green, D. L., Roberts, M. H. T., & Azami, J. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01627-x · Cited by 37 · see citing works
Systemic administration of α-lipoic acid suppresses excitability of nociceptive wide-dynamic range neurons in rat spinal trigeminal nucleus caudalis
Hidaka, S., Kanai, Y., Takehana, S., et al. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.06.003 · Cited by 19 · see citing works

Authors: Iannetti, G. D., & Mouraux, A.
Affiliations: University College London (GB)
UCLouvain (BE)
Corresponding author: Iannetti, G. D.
ORCID: Iannetti, G. D.
Mouraux, A.
Venue: Experimental Brain Research
Publisher: Springer Science and Business Media LLC
Published: 2010-07-06
Volume: 205
Issue: 1
Pages: 1-12
ISSN: 0014-4819 (ISSN-L)
1432-1106
DOI: 10.1007/s00221-010-2340-1
OpenAlex: W2115742360
Cited by: 554
References: 144
Citations by year: 2026: 12 · 2025: 24 · 2024: 28 · 2023: 35 · 2022: 32 · 2021: 34 · 2020: 43 · 2019: 30 · 2018: 38 · 2017: 35 · 2016: 45 · 2015: 46 · 2014: 44 · 2013: 43 · 2012: 37
FWCI: 3.38
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Experimental Brain Research (publishedVersion)
PubMed (publishedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council (BB/G01177X/2)
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: pain matrix, neuromatrix, pain perception, nociception, functional neuroimaging, nociceptive stimulation
MeSH terms: Animals, Brain, Brain Mapping, Humans, Models, Neurological, Neural Pathways, Nociceptors, Pain, Perception, Pain Threshold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

From the neuromatrix to the pain matrix (and back)

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks