The DOI matches its Crossref record; 276 of the 276 references it cites were found in a registry or an index.
The Insula: A “Hub of Activity” in Migraine
Open accessAbstract
The insula, a “cortical hub” buried within the lateral sulcus, is involved in a number of processes including goal-directed cognition, conscious awareness, autonomic regulation, interoception, and somatosensation. While some of these processes are well known in the clinical presentation of migraine (i.e., autonomic and somatosensory alterations), other more complex behaviors in migraine, such as conscious awareness and error detection, are less well described. Since the insula processes and relays afferent inputs from brain areas involved in these functions to areas involved in higher cortical function such as frontal, temporal, and parietal regions, it may be implicated as a brain region that translates the signals of altered internal milieu in migraine, along with other chronic pain conditions, through the insula into complex behaviors. Here we review how the insula function and structure is altered in migraine. As a brain region of a number of brain functions, it may serve as a model to study new potential clinical perspectives for migraine treatment.
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“Interoceptive awareness localizes to the insula,39 an area of the brain considered a “hub of activity” in migraine, playing a key role in integrating many of the dynamic processes of migraine (sensory, autonomic, cognitive, and emotional).40”
From Mechanisms of mindfulness in patients with migraine: Results of a qualitative study. (2023) · cites this paper as [39]
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Cites
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Cited by
Sorted by citations
Garcia, R. G., Lin, R. L., Lee, J., Kim, J., Barbieri, R., Sclocco, R., Wasan, A. D., Edwards, R. R., Rosen, B. R., Hadjikhani, N. K., et al. (2017) · Pain · doi:10.1097/j.pain.0000000000000930 · Cited by 137
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Self-citation
Metadata
- Authors
- Borsook, D., Veggeberg, R., Erpelding, N., Borra, R., Linnman, C., Burstein, R., & Becerra, L.
- Affiliations
- Boston Children's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Borsook, David
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2016-07-07
- Volume
- 22
- Issue
- 6
- Pages
- 632-652
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- PMC
- PMC5723020
- OpenAlex
- W1758874480
- Cited by
- 146
- References
- 276
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 11 · 2023: 16 · 2022: 14 · 2021: 17 · 2020: 20 · 2019: 14 · 2018: 8 · 2017: 15 · 2016: 6
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS056195, K24NS064050)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- insula, migraine, interoception, somatosensory perception, autonomic regulation, conscious awareness, error detection, goal-directed cognition, chronic pain, migraine treatment
- MeSH terms
- Animals, Brain Mapping, Cerebral Cortex, Cognition, Humans, Migraine Disorders, Nerve Net, Neural Pathways
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