Cited by 146Migraine and Headache StudiesPain Mechanisms and TreatmentsPsychosomatic Disorders and Their Treatments

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The Insula: A “Hub of Activity” in Migraine

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Borsook, David, Veggeberg, Rosanna, Erpelding, Nathalie, Borra, Ronald, Linnman, Clas, Burstein, Rami, Becerra, Lino·2016·The Neuroscientist

DOI 10.1177/1073858415601369PMC PMC5723020

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Abstract

The insula, a “cortical hub” buried within the lateral sulcus, is involved in a number of processes including goal-directed cognition, conscious awareness, autonomic regulation, interoception, and somatosensation. While some of these processes are well known in the clinical presentation of migraine (i.e., autonomic and somatosensory alterations), other more complex behaviors in migraine, such as conscious awareness and error detection, are less well described. Since the insula processes and relays afferent inputs from brain areas involved in these functions to areas involved in higher cortical function such as frontal, temporal, and parietal regions, it may be implicated as a brain region that translates the signals of altered internal milieu in migraine, along with other chronic pain conditions, through the insula into complex behaviors. Here we review how the insula function and structure is altered in migraine. As a brain region of a number of brain functions, it may serve as a model to study new potential clinical perspectives for migraine treatment.

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Authors: Borsook, D., Veggeberg, R., Erpelding, N., Borra, R., Linnman, C., Burstein, R., & Becerra, L.
Affiliations: Boston Children's Hospital (US)
Beth Israel Deaconess Medical Center (US)
Corresponding author: Borsook, David
ORCID: Borsook, David
Veggeberg, Rosanna
Borra, Ronald
Linnman, Clas
Burstein, Rami
Becerra, Lino
Venue: The Neuroscientist
Publisher: SAGE Publications
Published: 2016-07-07
Volume: 22
Issue: 6
Pages: 632-652
ISSN: 1073-8584 (ISSN-L)
1089-4098
DOI: 10.1177/1073858415601369
PMC: PMC5723020
OpenAlex: W1758874480
Cited by: 146
References: 276
Citations by year: 2026: 7 · 2025: 17 · 2024: 11 · 2023: 16 · 2022: 14 · 2021: 17 · 2020: 20 · 2019: 14 · 2018: 8 · 2017: 15 · 2016: 6
FWCI: 1.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: The Neuroscientist (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (R01NS056195, K24NS064050)
Topics: Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: insula, migraine, interoception, somatosensory perception, autonomic regulation, conscious awareness, error detection, goal-directed cognition, chronic pain, migraine treatment
MeSH terms: Animals, Brain Mapping, Cerebral Cortex, Cognition, Humans, Migraine Disorders, Nerve Net, Neural Pathways

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The Insula: A “Hub of Activity” in Migraine

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