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Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection
Open accessAbstract
In recent months it has emerged that the novel coronavirus—responsible for the COVID-19 pandemic—causes reduction of smell and taste in a large fraction of patients. The chemosensory deficits are often the earliest, and sometimes the only signs in otherwise asymptomatic carriers of the SARS-CoV-2 virus. The reasons for the surprisingly early and specific chemosensory dysfunction in COVID-19 are now beginning to be elucidated. In this hypothesis review, we discuss implications of the recent finding that the prevalence of smell and taste dysfunction in COVID-19 patients differs between populations, possibly because of differences in the spike protein of different virus strains or because of differences in the host proteins that enable virus entry, thus modifying infectivity. We review recent progress in defining underlying cellular and molecular mechanisms of the virus-induced anosmia, with a focus on the emerging crucial role of sustentacular cells in the olfactory epithelium. We critically examine the current evidence whether and how the SARS-CoV-2 virus can follow a route from the olfactory epithelium in the nose to the brain to achieve brain infection, and we discuss the prospects for using the smell and taste dysfunctions seen in COVID-19 as an early and rapid diagnostic screening tool.
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“Such chemosensory deficits experienced in COVID‐19 are often short‐lived, with most symptoms resolving in 7‐10 days, with sense of smell often returning slightly earlier than taste.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [299]
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Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
A new coronavirus associated with human respiratory disease in China
Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., Hu, Y., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., et al. (2020) · Nature · doi:10.1038/s41586-020-2008-3 · Cited by 11,688
Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166
Detection of SARS-CoV-2 in Different Types of Clinical Specimens
Wang, W., Xu, Y., Gao, R., Lu, R., Han, K., Wu, G., & Tan, W. (2020) · JAMA · doi:10.1001/jama.2020.3786 · Cited by 5,116
SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients
Zou, L., Ruan, F., Huang, M.-X., Liang, L.-J., Huang, H., Hong, Z.-S., Yu, J.-X., Kang, M., Song, Y.-C., Xia, J., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2001737 · Cited by 4,590
Korber, B., Fischer, W. M., Gnanakaran, S., Yoon, H., Theiler, J., Abfalterer, W., Hengartner, N., Giorgi, E. E., Bhattacharya, T., Foley, B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.043 · Cited by 4,281
Structural basis of receptor recognition by SARS-CoV-2
Shang, J., Ye, G., Shi, K., Wan, Y., Luo, C., Aihara, H., Geng, Q., Auerbach, A., & Li, F. (2020) · Nature · doi:10.1038/s41586-020-2179-y · Cited by 3,661
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa
Xu, H., Zhong, L., Deng, J., Peng, J., Dan, H., Zeng, X., Li, T., & Chen, Q. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0074-x · Cited by 2,838
Lechien, J. R., Chiesa-Estomba, C. M., De Siati, D. R., Horoi, M., Le Bon, S. D., Rodriguez, A., Dequanter, D., Blecic, S., El Afia, F., Distinguin, L., et al. (2020) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-020-05965-1 · Cited by 2,668
Research works printed but not linked: 17
- Asselta R, 2020, Aging (Albany NY), 12, 98
- 10.1101/2020.04.03.20047977 · DOI
- 10.1101/2020.06.16.151704 · DOI
- 10.1101/2020.05.08.084996 · DOI
- Dos Santos NPC, 2020, MedRxiv Preprint
- 10.1101/2020.07.04.20145870 · DOI
- Hwang CS, 2006, Acta Neurol Taiwan, 15
- 10.1016/0002-378 · DOI
- 10.1101/2020.07.15.204602 · DOI
- 10.1101/2020.06.08.139329 · DOI
- Netland J, 2008, J Virol, 82
- 10.1101/2020.05.04.20090902 · DOI
- Passarelli PC, 2020, Am J Dent, 33
- 10.1101/2020.05.14.097204 · DOI
- 10.1101/2020.06.15.20132134 · DOI
- 10.1101/2020.06.17.20106302 · DOI
- Yang XH, 2007, Comp Med, 57
Cited by
Sorted by citations
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults
Killingley, B., Mann, A., Kalinova, M., Boyers, A., Goonawardane, N., Zhou, J., Lindsell, K., Hare, S. S., Brown, J. C., Frise, R., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01780-9 · Cited by 532
Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
Flerlage, T., Boyd, D. F., Meliopoulos, V., Thomas, P. G., & Schultz‐Cherry, S. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00542-7 · Cited by 419
von Bartheld, C. S., Hagen, M. M., & Butowt, R. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00460 · Cited by 294
Self-citationZazhytska, M., Kodra, A. L., Hoagland, D. A., Frere, J. J., Fullard, J. F., Shayya, H. J., McArthur, N. G., Møller, R., Uhl, S. A., Omer, A. D., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.024 · Cited by 260
Metadata
- Authors
- Butowt, R., & von Bartheld, C. S.
- Affiliations
- Department of Molecular Cell Genetics, L. Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
- Center of Biomedical Research Excellence in Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2020-09-11
- Volume
- 27
- Issue
- 6
- Pages
- 582-603
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- PMC
- PMC7488171
- OpenAlex
- W3084613638
- Cited by
- 345
- References
- 143
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 38 · 2023: 73 · 2022: 97 · 2021: 91 · 2020: 8
- FWCI
- 23.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Neuroscientist (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- national institutes of health (GM103554)
- Uniwersytet Mikolaja Kopernika w Toruniu (Excellence Initiative -Research University ID-UB)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- anosmia, COVID-19 pandemic, SARS-CoV-2, olfactory dysfunction, taste disorders, olfactory epithelium, sustentacular cells, asymptomatic carriers
- MeSH terms
- COVID-19, Anosmia, Animals, Brain, Humans, Nasal Mucosa, Smell, Olfactory Perception
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