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Self-Efficacy Mediates the Relationship Between Depressive Symptoms and Medication Adherence Among Hypertensive African Americans
Abstract
Many studies have documented the negative effects of depression on adherence to recommended treatment; however, little is known about the mechanism underlying this relationship. Using the Kenny and Baron analytic framework of mediation, the authors assessed whether self-efficacy mediated the relationship between depression and medication adherence in 167 hypertensive African Americans followed in a primary care practice. Depressive symptoms are associated with poor medication adherence (β = .013, p = .036) and low self-efficacy (β = —.008, p = .023). Self-efficacy is negatively associated with medication adherence at follow-up (β = —.612, p < .001). The relationship between depressive symptoms and medication adherence becomes nonsignificant when controlling for self-efficacy (β = .010, p = .087). Implications for further examination into the mediating role of self-efficacy and the deleterious effect of depression on medication adherence are discussed.
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“Moreover, higher levels of self-efficacy can buffer against the effects of depression, which is a major adverse side effect of interferon-based therapies (13;14;34).”
From Reliability and validity of a self‐efficacy instrument for hepatitis C antiviral treatment regimens (2012) · cites this paper as [34]
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Metadata
- Authors
- Schoenthaler, A., Ogedegbe, G., & Allegrante, J. P.
- Affiliations
- Columbia University (US)
- Venue
- Health Education & Behavior
- Publisher
- SAGE Publications
- Published
- 2006-11-27
- Volume
- 36
- Issue
- 1
- Pages
- 127-137
- ISSN
- 1090-1981 (ISSN-L)
- 1552-6127
- OpenAlex
- W1995969486
- Cited by
- 139
- References
- 39
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 13 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 10 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 12 · 2014: 16 · 2013: 6 · 2012: 10
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Health Education & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (F31 081926-01)
- National Heart, Lung, and Blood Institute (R24HL076857, R01HL069408)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- self-efficacy, depressive symptoms, medication adherence, hypertension, African Americans, mediation, primary care
- MeSH terms
- Analysis of Variance, Antihypertensive Agents, Black or African American, Depression, Female, Humans, Hypertension, Male, Middle Aged, Comorbidity, Self Efficacy, Medication Adherence
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