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Evaluation of the Toxicity of Intravenous Delivery of Auroshell Particles (Gold–Silica Nanoshells)
Abstract
Gold nanoshells (155 nm in diameter with a coating of polyethylene glycol 5000) were evaluated for preclinical biocompatibility, toxicity, and biodistribution as part of a program to develop an injectable device for use in the photothermal ablation of tumors. The evaluation started with a complete good laboratory practice (GLP) compliant International Organization for Standardization (ISO)-10993 biocompatibility program, including cytotoxicity, pyrogenicity (US Pharmacopeia [USP] method in the rabbit), genotoxicity (bacterial mutagenicity, chromosomal aberration assay in Chinese hamster ovary cells, and in vivo mouse micronucleus), in vitro hemolysis, intracutaneous reactivity in the rabbit, sensitization (in the guinea pig maximization assay), and USP/ISO acute systemic toxicity in the mouse. There was no indication of toxicity in any of the studies. Subsequently, nanoshells were evaluated in vivo by intravenous (iv) infusion using a trehalose/water solution in a series of studies in mice, Sprague-Dawley rats, and Beagle dogs to assess toxicity for time durations of up to 404 days. Over the course of 14 GLP studies, the gold nanoshells were well tolerated and, when injected iv, no toxicities or bioincompatibilities were identified.
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Metadata
- Authors
- Gad, S. C., Sharp, K. L., Montgomery, C., Payne, J. D., & Goodrich, G. P.
- Venue
- International Journal of Toxicology
- Publisher
- SAGE Publications
- Published
- 2012-11
- Volume
- 31
- Issue
- 6
- Pages
- 584-594
- ISSN
- 1091-5818 (ISSN-L)
- 1092-874X
- OpenAlex
- W2050622829
- Cited by
- 227
- References
- 1
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gad, S. C., Sharp, K. L., Montgomery, C., Payne, J. D., & Goodrich, G. P. (2012). Evaluation of the Toxicity of Intravenous Delivery of Auroshell Particles (Gold–Silica Nanoshells). International Journal of Toxicology. https://doi.org/10.1177/1091581812465969
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