The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.
Review: Brain—immune communication psychoneuroimmunology of multiple sclerosis
Abstract
The central nervous system (CNS) and the immune system are two extremely complex and highly adaptive systems. In the face of a real or anticipated threat, be it physical (eg, infection) or psychological (eg, psychosocial stress) in nature, the two systems act in concert to provide optimal adaptation to the demanding internal or environmental conditions. During instances of well being, the communication between these two systems is well tuned and balanced. However, a disturbed crosstalk between the CNS and the immune system is thought to play a major role in a wide series of disorders characterized by a hyporesponsive or hyperresponsive immune system. In multiple sclerosis (MS), a chronic inflammatory and neurodegenerative disease, an excess of inflammatory processes seems to be a hallmark and there is growing evidence for a disturbed communication between the CNS and the immune system as a crucial pathogenic factor. While the exact mechanisms for these phenomena are still poorly understood, the young discipline of psychoneuroimmunology (PNI), which focuses on the mechanism underlying the brain to immune crosstalk, might offer some insights into the existing pathogenic mechanisms. Findings from the field of PNI might also help to gain a better understanding regarding the origin and course of MS clinical symptoms such as fatigue and depression.
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“For example, depression has been found to be related to neurological changes in the brain due to the demyelination process [20], treatment adherence to medical advice and treatments [21], immune functioning [22] and MS disease exacerbation [23].”
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Items 201–210 of 210
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Research works printed but not linked: 3
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MS quality of life, depression, and fatigue improve after mindfulness training: A randomized trial
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Metadata
- Authors
- Kern, S., & Ziemssen, T.
- Affiliations
- Technische Universität Dresden (DE)
- Corresponding author
- Kern, S.
- ORCID
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2008-01
- Volume
- 14
- Issue
- 1
- Pages
- 6-21
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2156639289
- Cited by
- 45
- References
- 210
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Roland Ernst Stiftung
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- multiple sclerosis, psychoneuroimmunology, brain-immune communication, neuroinflammation, neurodegeneration, psychosocial stress, fatigue, depression, MS pathogenesis
- MeSH terms
- Animals, Brain, Humans, Multiple Sclerosis, Psychoneuroimmunology, Neuroimmunomodulation
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