The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions
Abstract
Background There has been tremendous growth in research in pediatric multiple sclerosis (MS) and immune mediated central nervous system demyelinating disorders since operational definitions for these conditions were first proposed in 2007. Further, the International Pediatric Multiple Sclerosis Study Group (IPMSSG), which proposed the criteria, has expanded substantially in membership and in its international scope. Objective The purpose of this review is to revise the 2007 definitions in order to incorporate advances in delineating the clinical and neuroradiologic features of these disorders. Methods Through a consensus process, in which input was sought from the 150 members of the Study Group, criteria were drafted, revised and finalized. Final approval was sought through a web survey. Results Revised criteria are proposed for pediatric acute disseminated encephalomyelitis, pediatric clinically isolated syndrome, pediatric neuromyelitis optica and pediatric MS. These criteria were approved by 93% or more of the 56 Study Group members who responded to the final survey. Conclusions These definitions are proposed for clinical and research purposes. Their utility will depend on the outcomes of their application in prospective research.
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In the citing paper
“Although MS typically presents at age 20-50 years, approximately 0.5% of adults with MS have symptom onset at age 60 years or older. 42,43”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [43]
In the citing paper
“In younger children (<12 years) MS may present differently from adolescents and adults; encephalopathy, multifocal neurological deficits (often with prominent brainstem/cerebellar involvement) and seizures are more common.32”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [32]
In the citing paper
“Up to 5% of people with MS develop their first symptoms in childhood, almost always RRMS. 32”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [32]
In the citing paper
“The performance of the McDonald 2010 criteria has been tested in children with CIS and the criteria have a similar sensitivity/specificity for the development of MS as in adult populations 35 but should not be applied in the setting of encephalopathy (i.e.ADEM).32”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [32]
In the citing paper
“ADEM is almost always monophasic; however, an encephalopathic ADEM-like illness can sometimes be the first presentation of MS in both children 32,34 and adults 43 and diagnostic criteria for ADEM remain imperfect.”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [32]
In the citing paper
“The clinical, imaging and laboratory features of ADEM and MS overlap and diagnostic criteria emphasise the requirement of encephalopathy (altered level of consciousness, behavioural or cognitive change) in making the diagnosis of ADEM (Supplementary Panel 1).32”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [32]
In the citing paper
“Older children (≥12 years) usually present with clinical features and MRI findings similar to adults with CIS.32,34”
From Diagnosis of multiple sclerosis: progress and challenges (2017) · cites this paper as [32]
Citations
Cites
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22366 · Cited by 9,802
Self-citationRevised diagnostic criteria for neuromyelitis optica
Wingerchuk, D. M., Lennon, V. A., Pittock, S. J., Lucchinetti, C. F., & Weinshenker, B. G. (2006) · Neurology · doi:10.1212/01.wnl.0000216139.44259.74 · Cited by 2,568
Barkhof, F. (1997) · Brain · doi:10.1093/brain/120.11.2059 · Cited by 1,251
Fisniku, L. K., Brex, P. A., Altmann, D. R., Miszkiel, K. A., Benton, C. E., Lanyon, R., Thompson, A. J., & Miller, D. H. (2008) · Brain · doi:10.1093/brain/awm329 · Cited by 897
Consensus definitions proposed for pediatric multiple sclerosis and related disorders
Krupp, L., Banwell, B., & Tenembaum, S. N. (2007) · Neurology · doi:10.1212/01.wnl.0000259422.44235.a8 · Cited by 757
Self-citationAcute disseminated encephalomyelitis
Tenembaum, S. N., Chamoles, N., & Fejerman, N. (2002) · Neurology · doi:10.1212/wnl.59.8.1224 · Cited by 708
Self-citationIncreased Relapse Rate in Pediatric-Onset Compared With Adult-Onset Multiple Sclerosis
Gorman, M., Healy, B. C., Polgar‐Turcsanyi, M., & Chitnis, T. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.505 · Cited by 459
Self-citationEarly onset multiple sclerosis
Бойко, А. Н., Vorobeychik, G., Paty, D. W., Devonshire, V., & Sadovnick, A. D. (2002) · Neurology · doi:10.1212/wnl.59.7.1006 · Cited by 417
Acute Disseminated Encephalomyelitis in Childhood: Epidemiologic, Clinical and Laboratory Features
Leake, J. A. D., Albani, S., Kao, A. S., Senac, M. O., Billman, G. F., Nespeca, M., Paulino, A., Quintela, E. R., Sawyer, M. H., & Bradley, J. S. (2004) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000133048.75452.dd · Cited by 411
Course and prognosis in early-onset MS
Simone, I. L., Carrara, D., Tortorella, C., Liguori, M., Lepore, V. L., Pellegrini, F., Bellacosa, A., Ceccarelli, A., Pavone, I., & Livrea, P. (2002) · Neurology · doi:10.1212/01.wnl.0000036907.37650.8e · Cited by 341
Cited by
Sorted by citations
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167
Self-citationInternational consensus diagnostic criteria for neuromyelitis optica spectrum disorders
Wingerchuk, D. M., Banwell, B., Bennett, J. L., Cabre, P., Carroll, W., Chitnis, T., de Seze, J., Fujihara, K., Greenberg, B., Jacob, A., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001729 · Cited by 4,649
Self-citationA clinical approach to diagnosis of autoimmune encephalitis
Graus, F., Titulaer, M. J., Balu, R., Benseler, S. M., Bien, C. G., Cellucci, T., Cortese, I. C. M., Dale, R. C., Gelfand, J. M., Geschwind, M. D., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00401-9 · Cited by 4,580
Self-citationNeurological associations of COVID-19
Ellul, M. A., Benjamin, L., Singh, B., Lant, S., Michael, B. D., Easton, A., Kneen, R., Defres, S., Sejvar, J., & Solomon, T. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30221-0 · Cited by 2,156
Thompson, A. J., Baranzini, S. E., Geurts, J. J. G., Hemmer, B., & Ciccarelli, O. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30481-1 · Cited by 1,979
Metadata
- Authors
- Krupp, L. B., Tardieu, M., Amato, M. P., Banwell, B., Chitnis, T., Dale, R. C., Ghezzi, A., Hintzen, R., Kornberg, A., Pohl, D., Rostasy, K., Tenembaum, S., Wassmer, E., & for the International Pediatric Multiple Sclerosis Study Group
- Affiliations
- Stony Brook University Hospital (US)
- Hôpitaux universitaires Paris Sud (FR)
- University of Florence (IT)
- Children's Hospital of Philadelphia (US)
- Massachusetts General Hospital (US)
- The University of Sydney (AU)
- Centro Studi Sclerosi Multipl, Ospedale di Gallarate, Italy
- Erasmus MC (NL)
- Royal Children's Hospital (AU)
- Children's Hospital of Eastern Ontario (CA)
- Innsbruck Medical University (AT)
- Garrahan Hospital (AR)
- Birmingham Children's Hospital (GB)
- Corresponding author
- Krupp, Lauren B
- Tardieu, Marc
- ORCID
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2013-04-09
- Volume
- 19
- Issue
- 10
- Pages
- 1261-1267
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2025358672
- Cited by
- 1,130
- References
- 37
- Citations by year
- 2026: 57 · 2025: 74 · 2024: 95 · 2023: 111 · 2022: 102 · 2021: 106 · 2020: 99 · 2019: 100 · 2018: 98 · 2017: 93 · 2016: 80 · 2015: 60 · 2014: 42 · 2013: 10
- FWCI
- 47.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Keywords
- pediatric multiple sclerosis, diagnostic criteria, acute disseminated encephalomyelitis, neuromyelitis optica, clinical features, consensus definition
- MeSH terms
- Child, Encephalomyelitis, Acute Disseminated, Humans, Multiple Sclerosis, Neuromyelitis Optica, Pediatrics, Demyelinating Autoimmune Diseases, CNS
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