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A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa
Open accessAbstract
Depression is prevalent among people living with HIV in South Africa and interferes with adherence to antiretroviral therapy. This study evaluated a nurse-delivered, cognitive behavioral therapy intervention for adherence and depression among antiretroviral therapy users with depression in South Africa ( n = 14). Primary outcomes were depression, antiretroviral therapy adherence, feasibility, and acceptability. Findings support robust improvements in mood through a 3-month follow up. Antiretroviral therapy adherence was maintained during the intervention period. Participant retention supports acceptability; however, modest provider fidelity despite intensive supervision warrants additional attention to feasibility. Future effectiveness research is needed to evaluate this nurse-delivered cognitive behavioral therapy intervention for adherence and depression in this context.
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There has been some evidence of the challenges in implementing the cognitive component of CBT in this setting.
“Further, there also has been some evidence of the challenges in implementing the cognitive component of CBT in this setting (Andersen et al., 2016).”
From The Application of Mindfulness for Individuals Living with HIV in South Africa: a Hybrid Effectiveness-Implementation Pilot Study (2018) · cites this paper as Andersen et al., 2016
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References 39 · Cited by 84
Research works printed but not linked: 33
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Metadata
- Authors
- Andersen, L. S., Magidson, J. F., O’Cleirigh, C., Remmert, J. E., Kagee, A., Leaver, M., Stein, D. J., Safren, S. A., & Joska, J.
- Affiliations
- University of Cape Town (ZA)
- Harvard University (US)
- Stellenbosch University (ZA)
- South African Medical Research Council (ZA)
- University of Miami (US)
- Corresponding author
- Andersen, Lena S
- ORCID
- Venue
- Journal of Health Psychology
- Publisher
- SAGE Publications
- Published
- 2016-04-26
- Volume
- 23
- Issue
- 6
- Pages
- 776-787
- ISSN
- 1359-1053 (ISSN-L)
- 1461-7277
- PMC
- PMC5081274
- OpenAlex
- W2343593829
- Cited by
- 84
- References
- 39
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 9 · 2023: 12 · 2022: 15 · 2021: 10 · 2020: 14 · 2019: 8 · 2018: 1 · 2017: 5 · 2016: 2
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Health Psychology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (WT084323MA)
- United States Agency for International Development (674-A-00-88-00009-00)
- National Institute of Mental Health (K24MH094214, R01MH103770, T32MH093310)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- cognitive behavioral therapy, nurse-led intervention, HIV, depression, antiretroviral therapy adherence, medication adherence, mental health interventions, feasibility and acceptability, South Africa
- MeSH terms
- Adult, Depressive Disorder, Feasibility Studies, Female, Humans, Male, Middle Aged, Nurse Practitioners, Patient Acceptance of Health Care, Pilot Projects, South Africa, HIV Infections, Cognitive Behavioral Therapy, Anti-HIV Agents, Medication Adherence, Culturally Competent Care
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