The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Measuring social communication behaviors as a treatment endpoint in individuals with autism spectrum disorder
Abstract
Social communication impairments are a core deficit in autism spectrum disorder. Social communication deficit is also an early indicator of autism spectrum disorder and a factor in long-term outcomes. Thus, this symptom domain represents a critical treatment target. Identifying reliable and valid outcome measures for social communication across a range of treatment approaches is essential. Autism Speaks engaged a panel of experts to evaluate the readiness of available measures of social communication for use as outcome measures in clinical trials. The panel held monthly conference calls and two face-to-face meetings over 14 months. Key criteria used to evaluate measures included the relevance to the clinical target, coverage of the symptom domain, and psychometric properties (validity and reliability, as well as evidence of sensitivity to change). In all, 38 measures were evaluated and 6 measures were considered appropriate for use, with some limitations. This report discusses the relative strengths and weaknesses of existing social communication measures for use in clinical trials and identifies specific areas in need of further development.
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“We used the least-squares mean change from baseline in the ABC-mSW score as the primary outcome because a consensus panel found that the original ABC Lethargy–Social Withdrawal subscale had evidence supporting its use to assess social behavior in clinical trials involving persons with autism spectrum disorder34 and because the ABC-mSW increases specificity for social interaction.”
From Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder (2021) · cites this paper as [34]
Citations
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Vibert, B., Segura, P., Gallagher, L., Georgiades, S., Pervanidou, P., Thurm, A., Alexander, L. M., Anagnostou, E. A., Aoki, Y. Y., Birken, C. S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26568676
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Asynchronous Social Communication Development in Autism: A Component-Level Analysis
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Zhong, N., & Mazurek, M. O. (2026) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-026-07511-0
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Metadata
- Authors
- Anagnostou, E., Jones, N., Huerta, M., Halladay, A. K., Wang, P., Scahill, L., Horrigan, J. P., Kasari, C., Lord, C., Choi, D., Sullivan, K., & Dawson, G.
- Affiliations
- University of Toronto (CA)
- Neuren Pharmaceuticals Limited, USA
- Weill Cornell Medicine (US)
- Autism Speaks (US)
- Emory University (US)
- University of California, Los Angeles (US)
- Stony Brook University (US)
- NewYork–Presbyterian Hospital (US)
- Duke University, USA
- ORCID
- Venue
- Autism
- Publisher
- SAGE Publications
- Published
- 2014-08-05
- Volume
- 19
- Issue
- 5
- Pages
- 622-636
- ISSN
- 1362-3613 (ISSN-L)
- 1461-7005
- OpenAlex
- W2155746365
- Cited by
- 210
- References
- 142
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 19 · 2023: 17 · 2022: 26 · 2021: 30 · 2020: 23 · 2019: 23 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 6 · 2014: 1
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Autism Speaks
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- autism spectrum disorder, social communication, outcome measures, treatment endpoints, clinical trials, psychometric properties, validity, reliability statistics, sensitivity to change, expert panel review
- MeSH terms
- Autism Spectrum Disorder, Communication, Humans, Psychometrics, Social Behavior, Social Perception, Reproducibility of Results, Treatment Outcome, Outcome Assessment, Health Care, Social Skills
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