Cited by 210Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesBehavioral and Psychological Studies

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Measuring social communication behaviors as a treatment endpoint in individuals with autism spectrum disorder

Anagnostou, Evdokia, Jones, Nancy, Huerta, Marisela, Halladay, Alycia K, Wang, Paul, Scahill, Lawrence, Horrigan, Joseph P, Kasari, Connie, Lord, Cathy, Choi, Dennis, Sullivan, Katherine, Dawson, Geraldine·2015·Autism

DOI 10.1177/1362361314542955

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Abstract

Social communication impairments are a core deficit in autism spectrum disorder. Social communication deficit is also an early indicator of autism spectrum disorder and a factor in long-term outcomes. Thus, this symptom domain represents a critical treatment target. Identifying reliable and valid outcome measures for social communication across a range of treatment approaches is essential. Autism Speaks engaged a panel of experts to evaluate the readiness of available measures of social communication for use as outcome measures in clinical trials. The panel held monthly conference calls and two face-to-face meetings over 14 months. Key criteria used to evaluate measures included the relevance to the clinical target, coverage of the symptom domain, and psychometric properties (validity and reliability, as well as evidence of sensitivity to change). In all, 38 measures were evaluated and 6 measures were considered appropriate for use, with some limitations. This report discusses the relative strengths and weaknesses of existing social communication measures for use in clinical trials and identifies specific areas in need of further development.

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See all 210

Authors: Anagnostou, E., Jones, N., Huerta, M., Halladay, A. K., Wang, P., Scahill, L., Horrigan, J. P., Kasari, C., Lord, C., Choi, D., Sullivan, K., & Dawson, G.
Affiliations: University of Toronto (CA)
Neuren Pharmaceuticals Limited, USA
Weill Cornell Medicine (US)
Autism Speaks (US)
Emory University (US)
University of California, Los Angeles (US)
Stony Brook University (US)
NewYork–Presbyterian Hospital (US)
Duke University, USA
ORCID: Anagnostou, Evdokia
Jones, Nancy
Halladay, Alycia K
Wang, Paul
Scahill, Lawrence
Horrigan, Joseph P
Kasari, Connie
Choi, Dennis
Sullivan, Katherine
Venue: Autism
Publisher: SAGE Publications
Published: 2014-08-05
Volume: 19
Issue: 5
Pages: 622-636
ISSN: 1362-3613 (ISSN-L)
1461-7005
DOI: 10.1177/1362361314542955
OpenAlex: W2155746365
Cited by: 210
References: 142
Citations by year: 2026: 10 · 2025: 15 · 2024: 19 · 2023: 17 · 2022: 26 · 2021: 30 · 2020: 23 · 2019: 23 · 2018: 14 · 2017: 13 · 2016: 12 · 2015: 6 · 2014: 1
FWCI: 5.95
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Autism (publishedVersion)
PubMed (publishedVersion)
Funders: Autism Speaks
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Keywords: autism spectrum disorder, social communication, outcome measures, treatment endpoints, clinical trials, psychometric properties, validity, reliability statistics, sensitivity to change, expert panel review
MeSH terms: Autism Spectrum Disorder, Communication, Humans, Psychometrics, Social Behavior, Social Perception, Reproducibility of Results, Treatment Outcome, Outcome Assessment, Health Care, Social Skills

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Measuring social communication behaviors as a treatment endpoint in individuals with autism spectrum disorder

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