White matter lesions rather than amyloid-β burden are associated with cognitive decline in Alzheimer's disease
Abstract
We assessed the severity of amyloid-β accumulation and white matter lesions (WML) in the brain, and their association with cognitive decline, in patients (n = 47) with Alzheimer's disease (AD). The mean cortical standardized uptake value ratio (mcSUVR) was derived from amyloid positron emission tomography, while the percentage of WML area relative to brain parenchymal area was determined using magnetic resonance imaging. Cognitive decline was positively correlated with WML severity ( r = 0.50, p = 0.042) but not mcSUVR (Aβ accumulation). Managing vascular risk factors can prevent cognitive decline in patients with AD.
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- Authors
- Kasahara, H., Ikeda, M., Makioka, K., Nakamura, T., Takahashi, R., Kawarabayashi, T., Sanada, E., Suto, T., Higuchi, T., Tsushima, Y., & Ikeda, Y.
- Affiliations
- Gunma University (JP)
- Saitama Medical University (JP)
- Gunma University Hospital (JP)
- Corresponding author
- Ikeda, Yoshio
- ORCID
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2025-02-16
- Volume
- 104
- Issue
- 2
- Pages
- 319-324
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W4407669301
- Semantic Scholar
- 994d04f98a446d6bc1b2577d6dc3bb9b453d9968
- Cited by
- 0
- References
- 30
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22K07511, 21K15675)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, white matter lesions
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Amyloid beta-Peptides, Positron-Emission Tomography, Cognitive Dysfunction, White Matter
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