Cited by 0Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

White matter lesions rather than amyloid-β burden are associated with cognitive decline in Alzheimer's disease

Kasahara, Hiroo, Ikeda, Masaki, Makioka, Kouki, Nakamura, Takumi, Takahashi, Ryoma, Kawarabayashi, Takeshi, Sanada, Etsuko, Suto, Takayuki +3 more·2025·Journal of Alzheimer’s Disease

Abstract

We assessed the severity of amyloid-β accumulation and white matter lesions (WML) in the brain, and their association with cognitive decline, in patients (n = 47) with Alzheimer's disease (AD). The mean cortical standardized uptake value ratio (mcSUVR) was derived from amyloid positron emission tomography, while the percentage of WML area relative to brain parenchymal area was determined using magnetic resonance imaging. Cognitive decline was positively correlated with WML severity ( r = 0.50, p = 0.042) but not mcSUVR (Aβ accumulation). Managing vascular risk factors can prevent cognitive decline in patients with AD.

Integrity signals

Registry

Crossref · 10.1177/13872877251316516

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Still being checked.

Authors
Kasahara, H., Ikeda, M., Makioka, K., Nakamura, T., Takahashi, R., Kawarabayashi, T., Sanada, E., Suto, T., Higuchi, T., Tsushima, Y., & Ikeda, Y.
Affiliations
  • Gunma University (JP)
  • Saitama Medical University (JP)
  • Gunma University Hospital (JP)
Corresponding author
Ikeda, Yoshio
Venue
Journal of Alzheimer’s Disease
Published
2025-02-16
Volume
104
Issue
2
Pages
319-324
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W4407669301
Cited by
0
References
30
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (22K07511, 21K15675)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
Alzheimer's disease, white matter lesions
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Amyloid beta-Peptides, Positron-Emission Tomography, Cognitive Dysfunction, White Matter

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review