Potential for intestinal transplantation after acute mesenteric ischemia in patients aged less than 70 years: A population-based study
Open accessAbstract
BACKGROUND AND OBJECTIVE: Acute mesenteric ischemia (AMI) has a high mortality rate due to the development of bowel necrosis. Patients are often ruled outside active care if a large proportion of small bowel is necrotic. With the development of treatment for short bowel syndrome (SBS) and intestinal transplantation methods, long-term survival is possible even after extensive small bowel resections. This study aims to assess the incidence of SBS and potentially suitable candidates for intestinal transplantation among patients treated for AMI. METHODS: This population-based retrospective study comprised patients aged less than 70 years and diagnosed with AMI between January 2006 and October 2020 in Helsinki and Uusimaa health care district, Finland. RESULTS: Altogether, AMI was diagnosed in 711 patients, of whom 133 (19%) were aged below 70. An intervention was performed in 110 (83%) patients. Of these 133 patients, 16 (12%) were ruled outside active treatment due to extensive small bowel necrosis at exploratory laparotomy, of whom 6 (5%) were potentially suitable for intestinal transplantation. Two patients were considered as potential candidates for intestinal transplantation at bowel resection but died of AMI. Nine (7%) patients needed parenteral nutrition after resection, and two of them (2%) developed SBS. Only one patient needed long-term parenteral nutrition after hospital discharge. This patient remained dependent on parenteral nutrition but died before evaluation of intestinal transplantation could be carried out while the other patient was able to return to enteral nutrition. CONCLUSIONS: A small number of patients with AMI below 70 years of age are potentially eligible for intestinal transplantation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Only a small number of patients with short-bowel syndrome from acute mesenteric ischemia are potentially eligible for intestinal transplantation.
“a recent study found only a small number of patients are potentially eligible for intestinal transplantation in these cases [63].”
From Revascularization Strategies for Acute and Chronic Mesenteric Ischemia: A Narrative Review (2024) · cites this paper as [63]
In one study, 2% of all patients with AMI developed SBS and only 1% received PN after discharge.
“In one study, 2% of all patients with AMI developed SBS and only 1% received PN after discharge.”
It was estimated that 5% of patients with AMI under 70 years of age could have been candidates for intestinal transplantation after resection of extensive bowel necrosis.
“It was estimated that 5% of patients with AMI under 70years of age could have been candidates for intestinal transplantation after resection of extensive bowel necrosis. 184”
Cites
Messing, B., Crenn, P. P., Beau, P., Boutron‐Ruault, M., Rambaud, J., & Matuchansky, C. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70388-4 · Cited by 627 · see citing works
Intestinal Transplant Registry Report: Global Activity and Trends
Grant, D. R., Abu-Elmagd, K. M., Mazariegos, G. V., et al. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12979 · Cited by 451 · see citing works
ESTES guidelines: acute mesenteric ischaemia
Tilsed, J. V. T., Casamassima, A., Kurihara, H., Mariani, D., Martinez, I., Pereira, J., Ponchietti, L., Shamiyeh, A., al-Ayoubi, F., Barco, L. A. B., et al. (2016) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-016-0634-0 · Cited by 382 · see citing works
Kougias, P., Lau, D., El Sayed, H. F., Zhou, W., Huynh, T. T., & Lin, P. H. (2007) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2007.04.045 · Cited by 303 · see citing works
Pironi, L., Joly, F., Forbes, A., Colomb, V., Łyszkowska, M., Baxter, J. P., Gabe, S. M., Hébuterne, X., Gambarara, M., Gottrand, F., et al. (2010) · Gut · doi:10.1136/gut.2010.223255 · Cited by 281 · see citing works
Understanding short bowel syndrome: Current status and future perspectives
Massironi, S., Cavalcoli, F., Rausa, E., Invernizzi, P., Braga, M., & Vecchi, M. L. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.11.013 · Cited by 197 · see citing works
Acosta, S., & Björck, M. (2003) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2002.1893 · Cited by 158 · see citing works
Candidates for Intestinal Transplantation: A Multicenter Survey in Europe
Pironi, L., Hébuterne, X., Gossum, A. V., et al. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00710.x · Cited by 157 · see citing works
A review of the quality of life of adult patients treated with long-term parenteral nutrition
Baxter, J. P., Fayers, P. M., & McKinlay, A. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.05.003 · Cited by 127 · see citing works
Long-term results after surgery for acute mesenteric ischemia
Klempnauer, J., Grothues, F., Bektas, H., & Pichlmayr, R. (1997) · Surgery · doi:10.1016/s0039-6060(97)90351-2 · Cited by 119 · see citing works
The impact of home parenteral nutrition on daily life—A review
Waal, G. H., Schoonhoven, L., Jansen, J. B. �. �., et al. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.10.002 · Cited by 119 · see citing works
Parenteral Nutrition and Intestinal Failure
Bielawska, B., & Allard, J. P. (2017) · Nutrients · doi:10.3390/nu9050466 · Cited by 108 · see citing works
Roussel, A., Castier, Y., Nuzzo, A., Pellenc, Q., Sibert, A., Panis, Y., Bouhnik, Y., & Corcos, O. (2015) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2015.06.204 · Cited by 92 · see citing works
Survival after Operations for Ischaemic Bowel Disease
Wadman, M. (2000) · The European Journal of Surgery · doi:10.1080/110241500447263 · Cited by 78 · see citing works
Postoperative Short Bowel Syndrome
Thompson, J. S., DiBaise, J. K., Iyer, K. R., et al. (2005) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2005.02.034 · Cited by 75 · see citing works
Avitzur, Y., Wang, J. Y., de Silva, N. T., et al. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000735 · Cited by 74 · see citing works
Management and Complications of Short Bowel Syndrome: an Updated Review
Carroll, R. E., Benedetti, E., Schowalter, J., & Buchman, A. L. (2016) · Current Gastroenterology Reports · doi:10.1007/s11894-016-0511-3 · Cited by 74 · see citing works
Redefining short bowel syndrome in the 21st century
Cohran, V. C., Prozialeck, J. D., & Cole, C. R. (2016) · Pediatric Research · doi:10.1038/pr.2016.265 · Cited by 61 · see citing works
Yang, S., Fan, X., Ding, W., Liu, B., Meng, J., Xu, D., He, C., Yu, W., Wu, X., & Li, J. (2015) · Thrombosis Research · doi:10.1016/j.thromres.2014.10.018 · Cited by 58 · see citing works
Carver, T. W., Vora, R. S., & Taneja, A. (2016) · Critical Care Clinics · doi:10.1016/j.ccc.2015.11.001 · Cited by 58 · see citing works
Intestinal Transplantation: Current Status
Fryer, J. P. (2007) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2007.01.001 · Cited by 49 · see citing works
Tolonen, M., Lemma, A., Vikatmaa, P., Peltola, E., Mentula, P., Björkman, P., Leppäniemi, A., & Sallinen, V. (2021) · Journal of Trauma and Acute Care Surgery · doi:10.1097/ta.0000000000003305 · Cited by 46 · see citing works
Self-citationBlüthner, E., Bednarsch, J., Stockmann, M., Karber, M., Pevny, S., Maasberg, S., Gerlach, U. A., Pascher, A., Wiedenmann, B. J., Pratschke, J., et al. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1531 · Cited by 38 · see citing works
Ding, W., Wang, K., Liu, B., Fan, X., Wang, S., Cao, J., Wu, X., & Li, J. (2017) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000799 · Cited by 31 · see citing works
Pironi, L., Spinucci, G., Paganelli, F., et al. (2004) · Transplantation Proceedings · doi:10.1016/j.transproceed.2004.03.004 · Cited by 29 · see citing works
Ghanekar, A., & Grant, D. R. (2001) · Current Opinion in Critical Care · doi:10.1097/00075198-200104000-00013 · Cited by 29 · see citing works
What predicts the outcome in patients with intestinal ischemia? A single center experience
Grotelüschen, R., Bergmann, W., Welte, M. N., Reeh, M., Izbicki, J. R., & Bachmann, K. A. (2019) · Journal of Visceral Surgery · doi:10.1016/j.jviscsurg.2019.01.007 · Cited by 28 · see citing works
Saqui, O., Fernandes, G. F., & Allard, J. P. (2013) · Nutrition in Clinical Practice · doi:10.1177/0884533613516129 · Cited by 27 · see citing works
Quality of life on long-term parenteral nutrition
Avitzur, Y., & Miserachs, M. (2018) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000503 · Cited by 23 · see citing works
O’Keefe, S. J., & Matarese, L. E. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0020-x · Cited by 14 · see citing works
Small Bowel Transplantation: Past, Present and Future
Sigalet, D. L., Kneteman, N. M., & Thomson, A. B. R. (2008) · Digestive Diseases · doi:10.1159/000171364 · Cited by 12 · see citing works
Reconstructive Surgery for Intestinal Failure
Witte, M. B. (2019) · Visceral Medicine · doi:10.1159/000503042 · Cited by 12 · see citing works
Long-term prognosis and a prediction model for acute bowel ischaemia following cardiac surgery
Ariyaratnam, P., Vijayan, A., Cale, A. R., Cowen, M. E., Haqzad, Y. S., Balasubramanian, S. K., & Loubani, M. (2015) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivv148 · Cited by 7 · see citing works
First Spanish series of intestinal transplantation in adult recipients
Díaz, J. C. M., González, E. M., García, J. I., et al. (2006) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082006001000002 · Cited by 3 · see citing works
Small bowel transplant: state-of-the-art vascular and nonvascular imaging
Panick, C. E. P., Partovi, S., Liu, P. S., et al. (2020) · Abdominal Radiology · doi:10.1007/s00261-019-02377-6 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Koelemay, M. J., Geelkerken, R. H., Kärkkäinen, J., Leone, N., Antoniou, G. A., de Bruin, J. L., Gombert, A., Gottsätter, A., Iborra, E., Ronchey, S., et al. (2025) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2025.06.010 · Cited by 123 · see citing works
Self-citationRevascularization Strategies for Acute and Chronic Mesenteric Ischemia: A Narrative Review
Gries, J. J., Sakamoto, T., Chen, B., Virk, H. U. H., Alam, M., & Krittanawong, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051217 · Cited by 19 · see citing works
- Authors
- Lemma, A., Pikkarainen, S., Pohju, A., Tolonen, M., Mentula, P., Vikatmaa, P., Leppäniemi, A., Mäkisalo, H., & Sallinen, V.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Sallinen, Ville
- ORCID
- Venue
- Scandinavian Journal of Surgery
- Publisher
- SAGE Publications
- Published
- 2023-02-08
- Volume
- 112
- Issue
- 2
- Pages
- 77-85
- ISSN
- 1457-4969 (ISSN-L)
- 1799-7267
- OpenAlex
- W4319656639
- Cited by
- 5
- References
- 35
- Citations by year
- 2025: 4 · 2024: 1
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Scandinavian Journal of Surgery (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- Funders
- Helsinki University Hospital Research grants
- Mary and Georg Ehrnrooth’s foundation
- The Finnish Medical Foundation
- Vatsatautien tutkimussäätiö Foundation
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Keywords
- acute mesenteric ischemia, intestinal transplantation, short bowel syndrome, small bowel necrosis, bowel resection, parenteral nutrition, enteral nutrition, young adults
- MeSH terms
- Humans, Intestine, Small, Necrosis, Retrospective Studies, Short Bowel Syndrome, Mesenteric Ischemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
