Cited by 21MicroRNA in disease regulationCancer-related molecular mechanisms researchGlioma Diagnosis and Treatment

MicroRNA-96 Regulates Apoptosis by Targeting PDCD4 in Human Glioma Cells

Open access
Ma, Qing-qing, Huang, Jian-ting, Xiong, Yun-gang, Yang, Xiao-yan, Han, Ran, Zhu, Wang-wen·2017·Technology in Cancer Research & Treatment

Abstract

Glioblastoma multiforme, the most common and aggressive form of primary brain tumor, presents a dismal prognosis. MicroRNAs play a critical role in the initiation, progression, and metastasis of cancer; however, the potential biological role of miRNAs in glioblastoma multiforme remains largely unknown. In our study, we found that microRNA-96 is upregulated in glioma tissues than in normal human brains. Transfection of microRNA-96 mimics into glioma cells significantly decreases apoptosis by suppressing PDCD4, a well-known tumor suppressor that is involved in apoptosis. In contrast, knockdown of microRNA-96 enhanced apoptosis. In vivo, microRNA-96 overexpression inhibits the apoptosis and increases tumor growth. These data suggest that microRNA-96 is a potential molecular target for glioma treatment.

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Crossref · 10.1177/1533034616629260

Cites

21 of 21 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 3

  1. Yu JJ, 2014, Med Oncol, 31, 1357
  2. Agarwal V, 2015, Elife, 4
  3. Weller M, 2011, Swiss Med Wkly, 141, w13210

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Authors
Ma, Q.-Q., Huang, J.-T., Xiong, Y.-G., Yang, X.-Y., Han, R., & Zhu, W.-W.
Affiliations
  • Clinical Laboratory, Guizhou Aerospace Hospital, Zunyi, China
  • Department of Anesthesiology, The People’s Hospital of Chengyang District, Qingdao, China
Corresponding author
Zhu, Wang-wen
Venue
Technology in Cancer Research & Treatment
Published
2016-07-07
Volume
16
Issue
1
Pages
92-98
ISSN
  • 1533-0338 (ISSN-L)
  • 1533-0346
OpenAlex
W2281911306
Cited by
21
References
21
Citations by year
2026: 1 · 2023: 3 · 2022: 3 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 1
FWCI
1.58
Type
journal article
Language
en
Open access
Locations
  • Technology in Cancer Research & Treatment (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
Keywords
PDCD4, glioblastoma, glioma, apoptosis, tumor suppressor, microRNA target regulation, tumor growth, therapeutic target
MeSH terms
Animals, Disease Models, Animal, Glioma, Humans, Gene Expression, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, RNA-Binding Proteins, Apoptosis, Xenograft Model Antitumor Assays, RNA Interference, MicroRNAs, Cell Line, Tumor, Apoptosis Regulatory Proteins, Mice

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