MicroRNA-96 Regulates Apoptosis by Targeting PDCD4 in Human Glioma Cells
Open accessAbstract
Glioblastoma multiforme, the most common and aggressive form of primary brain tumor, presents a dismal prognosis. MicroRNAs play a critical role in the initiation, progression, and metastasis of cancer; however, the potential biological role of miRNAs in glioblastoma multiforme remains largely unknown. In our study, we found that microRNA-96 is upregulated in glioma tissues than in normal human brains. Transfection of microRNA-96 mimics into glioma cells significantly decreases apoptosis by suppressing PDCD4, a well-known tumor suppressor that is involved in apoptosis. In contrast, knockdown of microRNA-96 enhanced apoptosis. In vivo, microRNA-96 overexpression inhibits the apoptosis and increases tumor growth. These data suggest that microRNA-96 is a potential molecular target for glioma treatment.
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- Authors
- Ma, Q.-Q., Huang, J.-T., Xiong, Y.-G., Yang, X.-Y., Han, R., & Zhu, W.-W.
- Affiliations
- Clinical Laboratory, Guizhou Aerospace Hospital, Zunyi, China
- Department of Anesthesiology, The People’s Hospital of Chengyang District, Qingdao, China
- Corresponding author
- Zhu, Wang-wen
- Venue
- Technology in Cancer Research & Treatment
- Publisher
- SAGE Publications
- Published
- 2016-07-07
- Volume
- 16
- Issue
- 1
- Pages
- 92-98
- ISSN
- 1533-0338 (ISSN-L)
- 1533-0346
- PMC
- PMC5616120
- OpenAlex
- W2281911306
- Semantic Scholar
- 166f9fcd0d0da4960b10949cc2ecc336ba0dacb9
- Cited by
- 21
- References
- 21
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 3 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Technology in Cancer Research & Treatment (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- PDCD4, glioblastoma, glioma, apoptosis, tumor suppressor, microRNA target regulation, tumor growth, therapeutic target
- MeSH terms
- Animals, Disease Models, Animal, Glioma, Humans, Gene Expression, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, RNA-Binding Proteins, Apoptosis, Xenograft Model Antitumor Assays, RNA Interference, MicroRNAs, Cell Line, Tumor, Apoptosis Regulatory Proteins, Mice
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