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Cited by 17MicroRNA in disease regulationGlioma Diagnosis and TreatmentPI3K/AKT/mTOR signaling in cancer

The Role of Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma

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Ghaffarian Zirak, Roshanak, Tajik, Hurie, Asadi, Jahanbakhsh, Hashemian, Pedram, Javid, Hossein·2022·Iranian Journal of Pathology
DOI 10.30699/ijp.2022.539029.2726PMC PMC9013863
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Abstract

Glioblastoma is a type of brain cancer with aggressive and invasive nature. Such features result from increased proliferation and migration and also poor apoptosis of glioma cells leading to resistance to current treatments such as chemotherapy and radiotherapy. In recent studies, micro RNAs have been introduced as a novel target for treating glioblastoma via regulation of apoptotic signaling pathway, remarkably PI3K/AKT, which affect cellular functions and blockage or progression of the tumor. In this review, we focus on PI3K/AKT signaling pathway and other related apoptotic processes contributing to glioblastoma and investigate the role of micro RNAs interfering in apoptosis, invasion and proliferation of glioma through such apoptotic processes pathways. Databases NCBI, PubMed, and Web of Science were searched for published English articles using keywords such as 'miRNA OR microRNA', 'Glioblastoma', 'apoptotic pathways', 'PI3K and AKT', 'Caspase signaling Pathway' and 'Notch pathway'. Most articles were published from 7 May 2015 to 16 June 2020. This study focused on PI3K/AKT signaling pathway affecting glioma cells in separated subparts. Also, other related apoptotic pathways as the Caspase cycle and Notch have been also investigated. Nearly 40 miRNAs were found as tumor suppressors or onco-miRNA, and their targets, which regulated subcomponents participating in proliferation, invasion, and apoptosis of the tumoral cells. Our review reveals that miRNAs affect key molecules in signaling apoptotic pathways, partly PI3K/AKT, making them potential therapeutic targets to overcome the tumor. However, their utility as a novel treatment for glioblastoma requires further examination and investigation.

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Authors
Ghaffarian Zirak, R., Tajik, H., Asadi, J., Hashemian, P., & Javid, H.
Affiliations
  • Shahrekord University (IR)
  • Golestan University of Medical Sciences (IR)
  • Mashhad University of Medical Sciences (IR)
Corresponding author
  • Tajik, Hurie
  • Javid, Hossein
ORCID
Venue
Iranian Journal of Pathology
Publisher
Farname, Inc.
Published
2022-03-08
Volume
17
Issue
2
Pages
122-136
ISSN
  • 1735-5303 (ISSN-L)
  • 2345-3656
DOI
10.30699/ijp.2022.539029.2726
PMC
PMC9013863
OpenAlex
W4226248319
Cited by
17
References
4
Citations by year
2026: 2 · 2025: 6 · 2024: 4 · 2023: 1 · 2022: 4
FWCI
0.45
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Iranian journal of pathology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
glioblastoma, microRNA, PI3K/Akt signaling, apoptosis, Notch signaling, tumor suppressor microRNA, oncogenic microRNA, cell proliferation, tumor invasion, therapeutic target

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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