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Cited by 68Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsHistorical and Modern Theater Studies

Neuropsychological and neuroimaging markers in early versus late-onset Alzheimer’s disease.

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Kaiser, Natalie C., Melrose, Rebecca J., Liu, Collin, Sultzer, David L., Jimenez, Elvira, Su, Michael, Monserratt, Lorena, Mendez, Mario F.·2012·American Journal of Alzheimer's Disease & Other Dementias®
DOI 10.1177/1533317512459798PMC PMC4112191
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Abstract

Background: Early-onset Alzheimer’s disease (EOAD) has been overshadowed by the more common late-onset AD (LOAD). Yet, the literature indicates EOAD may have less hippocampal-memory presentations and more focal neocortical localization early in the disease. Objective: To evaluate these proposed differences between these 2 forms of AD and to explore what they inform about differences in AD pathophysiology. Methods: In all, 21 patients with EOAD and 24 patients with LOAD matched for disease progression and severity were compared on neurocognitive measures and resting state fluorodeoxy-glucose positron–emission tomography (FDG-PET). Results: Patients with EOAD had worse executive functions with greater hypometabolism in the parietal regions; whereas patients with LOAD had worse confrontation naming and verbal recognition memory with greater hypometabolism in inferior frontotemporal regions. Conclusions: In addition to highlighting significant differences between EOAD and LOAD, these results reveal dissociation between executive deficits in AD and frontal hypometabolism, suggesting early disturbances of the parietal–frontal network in EOAD.

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  • EOAD patients exhibit a wider range of cognitive dysfunction, including non-memory cognitive domains, than LOAD patients.

    “while EOAD patients exhibit a wider range of cognitive dysfunction, which can also include non-memory cognitive domains (Fujimori et al., 1998; Kaiser et al., 2012; Smits et al., 2012).”

    From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Kaiser et al., 2012

    The Discussion reports worse performance by EOAD patients on several non-memory executive measures, supporting that part of the claim. It does not establish that EOAD patients have a wider range of cognitive dysfunction overall: LOAD patients performed worse on naming and recognition memory, and the Introduction notes conflicting findings across studies. (LLM, conf=0.82)

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Authors
Kaiser, N. C., Melrose, R. J., Liu, C., Sultzer, D. L., Jimenez, E., Su, M., Monserratt, L., & Mendez, M. F.
Affiliations
  • VA Greater Los Angeles Healthcare System (US)
  • University of California, Los Angeles (US)
Corresponding author
Kaiser, Natalie C.
ORCID
Venue
American Journal of Alzheimer's Disease & Other Dementias®
Publisher
SAGE Publications
Published
2012-09-17
Volume
27
Issue
7
Pages
520-529
ISSN
  • 0888-4897 (ISSN-L)
  • 1533-3175
  • 1938-2731
DOI
10.1177/1533317512459798
PMC
PMC4112191
OpenAlex
W2167680209
Cited by
68
References
2
Citations by year
2026: 5 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 17 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 1
FWCI
2.74
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • American Journal of Alzheimer s Disease & Other Dementias® (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R01AG034499-3, R01AG034499)
  • National Institute of Mental Health (R01MH056031, R01MH56031)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
early-onset Alzheimer's disease, late-onset Alzheimer's disease, executive function, FDG-PET hypometabolism, confrontation naming, verbal recognition memory, hippocampal-dependent memory, neuroimaging biomarkers, neuropsychological markers, frontal hypometabolism
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition Disorders, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Age of Onset, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography, Functional Neuroimaging

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