CoChat
Sign Up
Cited by 48Circadian rhythm and melatoninCancer, Stress, Anesthesia, and Immune ResponseDietary Effects on Health

Circadian timing in cancer treatment: the biological foundation for an integrative approach

Open access
Lis, Christopher G., Grutsch, James F., Wood, Patricia, You, Mark, Rich, Ivan, Hrushesky, William J M·2003·Integrative Cancer Therapies
DOI 10.1177/1534735403002002002
Open this paper in CoChat — free account

Abstract

Despite the many innovations that have occurred in cancer treatment, the age-specific mortality for most adult tumors has remained stable during the past 30 years. There have been clinically significant improvements in the outcomes of young and middle-aged patients, yet the vast majority of cancer patients are more than 50 years of age, among whom we observe few improvements in clinical outcomes. Clearly, many of today's cytotoxic agents have been shown to be effective in-vitro and in animal model systems; however, few have proved efficacious in dramatically improving survival outcomes in adult cancer. There is now increasing evidence to suggest that the administration of cytotoxic agents, at the appropriate circadian phase, can significantly increase the therapeutic index of current cancer therapies.

Integrity signals

Registry

Crossref · 10.1177/1534735403002002002

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Night-shift workers have a higher risk of developing cancer and poorer cancer prognosis.

    “Epidemiological studies have revealed that individuals who work night-shifts are at higher risk for developing cancer (Hansen, 2001; Kloog et al., 2009; Megdal et al., 2005; Schernhammer et al., 2006; Schernhammer et al., 2001; Viswanathan et al., 2007) or display poorer cancer prognosis (Lis et al., 2003).”

    From Circadian Rhythm Disruption Promotes Lung Tumorigenesis (2016) · cites this paper as Lis et al., 2003

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Lis, C. G., Grutsch, J. F., Wood, P., You, M., Rich, I., & Hrushesky, W. J. M.
Affiliations
Cancer Treatment Centers of America (US)
ORCID
Hrushesky, William J M
Venue
Integrative Cancer Therapies
Publisher
SAGE Publications
Published
2003-06
Volume
2
Issue
2
Pages
105-111
ISSN
  • 1534-7354 (ISSN-L)
  • 1552-695X
DOI
10.1177/1534735403002002002
OpenAlex
W2074945663
Cited by
48
References
36
Citations by year
2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
1.31
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Integrative Cancer Therapies (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
circadian rhythm, circadian timing, cancer therapy, cytotoxic drugs, timing of drug administration, therapeutic index, integrative oncology
MeSH terms
Adult, Age Factors, Aged, Antineoplastic Combined Chemotherapy Protocols, Circadian Rhythm, Clinical Trials as Topic, Drug Interactions, Female, Humans, Male, Middle Aged, Neoplasms, Risk Factors, Sensitivity and Specificity, Time Factors, Survival Analysis, Treatment Outcome, Risk Assessment, Chronotherapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review