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Cited by 131Phytochemicals and Medicinal PlantsCancer survivorship and careComplementary and Alternative Medicine Studies

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.

Effect of Withania somnifera (Ashwagandha) on the Development of Chemotherapy-Induced Fatigue and Quality of Life in Breast Cancer Patients

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Biswal, Biswa Mohan, Sulaiman, Siti Amrah, Ismail, Hasanah Che, Zakaria, Hasmat, Musa, Kamarul Imran·2013·Integrative Cancer Therapies
DOI 10.1177/1534735412464551
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Abstract

UNLABELLED: Hypothesis. Withania somnifera is an herb with antioxidant, anti-inflammatory, anticancer, antistress, and adaptogenic properties. Previous studies have shown its antistress effects in animals. Traditional Indian medicine has used it for centuries to alleviate fatigue and improve general well-being. METHODS: This is an open-label prospective nonrandomized comparative trial on 100 patients with breast cancer in all stages undergoing either a combination of chemotherapy with oral Withania somnifera or chemotherapy alone. The chemotherapy regimens were either taxotere, adriamycin, and cyclophosphamide or 5-fluorouracil, epirubicin, and cyclophosphamide. Withania somnifera root extract was administered to patients in the study group at a dose of 2 g every 8 hours, throughout the course of chemotherapy. The quality-of-life and fatigue scores were evaluated before, during, and on the last cycles of chemotherapy using the EORTC QLQ-C30 (Version 3), Piper Fatigue Scale (PFS), and Schwartz Cancer Fatigue Scale (SCFS-6). RESULTS: The median age distributions in the study and control arm were 51 years (range = 36-70) and 50.5 years (range = 32-71), respectively. The majority (77%) of patients had stage II and III disease. Patients in the control arm experienced statistically significant higher estimated marginal means of fatigue score compared with the study group (P < .001 PFS, P < .003 SCFS-6). Furthermore, various symptom scales of the EORTC QLQ-C30 were statistically significant in 7 out of 18 symptoms in the intervention group compared with the control group (P < .001). The 24-month overall survival for all stages in study and control group patients were 72% versus 56%, respectively; however, the result was not significant (P = .176), at a median follow-up duration of 26 months. CONCLUSIONS: Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life. However, further study with a larger sample size in a randomized trial is warranted to validate our findings.

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Citations

Cites

Research works printed but not linked: 16

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Metadata

Authors
Biswal, B. M., Sulaiman, S. A., Ismail, H. C., Zakaria, H., & Musa, K. I.
Affiliations
Universiti Sains Malaysia (MY)
ORCID
Venue
Integrative Cancer Therapies
Publisher
SAGE Publications
Published
2012-11-09
Volume
12
Issue
4
Pages
312-322
ISSN
  • 1534-7354 (ISSN-L)
  • 1552-695X
DOI
10.1177/1534735412464551
OpenAlex
W1986443532
Cited by
131
References
33
Citations by year
2026: 13 · 2025: 18 · 2024: 10 · 2023: 7 · 2022: 13 · 2021: 13 · 2020: 12 · 2019: 8 · 2018: 6 · 2017: 12 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 2
FWCI
13.19
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Integrative Cancer Therapies (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
Keywords
Withania somnifera, breast cancer, chemotherapy-induced fatigue, cancer-related fatigue, quality of life, complementary and alternative medicine, root extract, EORTC QLQ-C30, Piper Fatigue Scale, overall survival
MeSH terms
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Fatigue, Female, Humans, Phytotherapy, Middle Aged, Plant Extracts, Quality of Life, Treatment Outcome, Withania, Medication Adherence

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