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Wijeratne, E. M. K., Xu, Y.-M., Scherz‐Shouval, R., Marron, M. T., Rocha, D. D., Liu, M. X., Costa-Lotufo, L. V., Santagata, S., Lindquist, S. L., Whitesell, L. J., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401279n · Cited by 75 · see citing works

Rhizospheric biological weapons for growth enhancement and Meloidogyne incognita management in Withania somnifera cv. Poshita

Saikia, S. K., Tiwari, S., & Pandey, R. (2013) · Biological Control · doi:10.1016/j.biocontrol.2013.01.014 · Cited by 74 · see citing works

Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal models

Lee, W., Kim, T. H., Ku, S., Min, K., Lee, H., Kwon, T. K., & Bae, J. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.04.025 · Cited by 72 · see citing works

Standardized extract of Withania somnifera (Ashwagandha) markedly offsets rotenone-induced locomotor deficits, oxidative impairments and neurotoxicity in Drosophila melanogaster

Manjunath, M. J., & Muralidhara (2015) · Journal of Food Science and Technology · doi:10.1007/s13197-013-1219-0 · Cited by 69 · see citing works

Withania somnifera (Linn.) Dunal: a review of chemical and pharmacological diversity

Kalra, R., & Kaushik, N. (2017) · Phytochemistry Reviews · doi:10.1007/s11101-017-9504-6 · Cited by 69 · see citing works

Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells

Dar, N. J., Bhat, J. A., Satti, N. K., Sharma, P. R., Hamid, A., & Ahmad, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0044-7 · Cited by 69 · see citing works

Pharmacokinetic Study of Withanosides and Withanolides from Withania somnifera Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS)

Modi, S. J., Tiwari, A., Ghule, C., Pawar, S., Saste, G., Jagtap, S., Singh, R., Deshmukh, A., Girme, A., & Hingorani, L. (2022) · Molecules · doi:10.3390/molecules27051476 · Cited by 68 · see citing works

Role of mitogen‐activated protein kinases and Mcl‐1 in apoptosis induction by withaferin A in human breast cancer cells

Hahm, E., Lee, J., & Singh, S. V. (2013) · Molecular Carcinogenesis · doi:10.1002/mc.22050 · Cited by 68 · see citing works

Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells

Lee, J., Sehrawat, A., & Singh, S. V. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2239-6 · Cited by 68 · see citing works

Inhibitors of Intracellular Signaling Pathways that Lead to Stimulated Epidermal Pigmentation: Perspective of Anti-Pigmenting Agents

Imokawa, G., & Ishida, K. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058293 · Cited by 68 · see citing works

The Integration of Metabolomics and Next-Generation Sequencing Data to Elucidate the Pathways of Natural Product Metabolism in Medicinal Plants

Scossa, F., Benina, M., Alseekh, S., Zhang, Y., & Fernie, A. R. (2018) · Planta Medica · doi:10.1055/a-0630-1899 · Cited by 68 · see citing works

Rational use of Ashwagandha in Ayurveda (Traditional Indian Medicine) for health and healing

Joshi, V. K., & Joshi, A. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114101 · Cited by 65 · see citing works

A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study

Auddy, B., Hazra, J., Mitra, A., Abedon, B., Ghosal, S., & Nagar, B. (2008) · Cited by 65 · see citing works

Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review

Lerose, V., Ponticelli, M., Benedetto, N., Carlucci, V., Lela, L., Tzvetkov, N. T., & Milella, L. (2024) · Plants · doi:10.3390/plants13060771 · Cited by 63 · see citing works

An Aqueous Extract of <i>Withania somnifera</i> Root Inhibits Amyloid β Fibril Formation <i>In Vitro</i>

Kumar, S., Harris, R. J., Seal, C. J., & Okello, E. J. (2012) · Phytotherapy Research · doi:10.1002/ptr.3512 · Cited by 62 · see citing works

Unique Medicinal Properties of Withania somnifera: Phytochemical Constituents and Protein Component

Dar, P. A., Singh, L. R., Kamal, M. A., & Dar, T. A. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151125001751 · Cited by 61 · see citing works

Computational Evidence to Inhibition of Human Acetyl Cholinesterase by Withanolide A for Alzheimer Treatment

Grover, A., Shandilya, A., Agrawal, V., Bisaria, V. S., & Sundar, D. (2012) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2012.10507408 · Cited by 60 · see citing works

Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance

Rahman, M. M., Wang, X., Islam, M. R., Akash, S., Supti, F. A., Mitu, M. I., Harun-Or-Rashid, M., Aktar, M. N., Kali, M. S. K., Jahan, F. I., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.976385 · Cited by 59 · see citing works

Production of reactive oxygen species by withaferin A causes loss of type collagen expression and COX-2 expression through the PI3K/Akt, p38, and JNK pathways in rabbit articular chondrocytes

Yu, S., & Kim, S. J. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.08.026 · Cited by 59 · see citing works

Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway

Dar, N. J., Satti, N. K., Dutt, P., Hamid, A., & Ahmad, M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0515-5 · Cited by 57 · see citing works

Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model

Wongtrakul, J., Thongtan, T., Kumrapich, B., Saisawang, C., & Ketterman, A. J. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08172 · Cited by 52 · see citing works

Antiparkinsonian Effects of Aqueous Methanolic Extract of Hyoscyamus niger Seeds Result From its Monoamine Oxidase Inhibitory and Hydroxyl Radical Scavenging Potency

Sengupta, T. K., Vinayagam, J., Nagashayana, N., Gowda, B., Jaisankar, P., & Mohanakumar, K. P. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0289-x · Cited by 51 · see citing works

Withania somnifera (L.) Dunal (Ashwagandha); current understanding and future prospect as a potential drug candidate

Bhat, J. A., Akther, T., Najar, R. A., Rasool, F., & Hamid, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1029123 · Cited by 51 · see citing works

The antioxidant and neurochemical activity of Apium graveolens L. and its ameliorative effect on MPTP-induced Parkinson-like symptoms in mice

Chonpathompikunlert, P., Boonruamkaew, P., Sukketsiri, W., Hutamekalin, P., & Sroyraya, M. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2166-0 · Cited by 49 · see citing works

Withania somnifera Improves Ischemic Stroke Outcomes by Attenuating PARP1-AIF-Mediated Caspase-Independent Apoptosis

Raghavan, A., & Shah, Z. A. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8907-2 · Cited by 47 · see citing works

Role of ashwagandha methanolic extract in the regulation of thyroid profile in hypothyroidism modeled rats

Abdel-Wahhab, K. G., Mourad, H. H., Mannaa, F. A. E., Morsy, F. A., Hassan, L. K., & Taher, R. F. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04721-x · Cited by 47 · see citing works

Nephroprotective Effect ofWithania somnifera:A Dose-Dependent Study

Jeyanthi, T., & Subramanian, P. (2009) · Renal Failure · doi:10.3109/08860220903150320 · Cited by 47 · see citing works

Withania somnifera Root Extract Has Potent Cytotoxic Effect against Human Malignant Melanoma Cells

Halder, B., Singh, S., & Thakur, S. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137498 · Cited by 46 · see citing works

Effect of Withania somnifera Supplementation on Rotenone-Induced Oxidative Damage in Cerebellum and Striatum of the Male Mice Brain

Manjunath, M. J., & ., M. (2013) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524911313010007 · Cited by 45 · see citing works

Withania somnifera Prevents Morphine Withdrawal-Induced Decrease in Spine Density in Nucleus Accumbens Shell of Rats: A Confocal Laser Scanning Microscopy Study

Kasture, S. B., Vinci, S., Ibba, F., Puddu, A., Marongiu, M., Balasubramanian, M., Pisanu, A., Lecca, D., Zernig, G., & Acquas, E. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9069-2 · Cited by 44 · see citing works

Withaferin A Analogs That Target the AAA+ Chaperone p97

Tao, S., Tillotson, J., Wijeratne, E. M. K., Xu, Y.-M., Kang, M., Wu, T., Lau, E. C., Mesa, C., Mason, D. J., Brown, R. V., et al. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00367 · Cited by 44 · see citing works

Clinical pharmacokinetic evaluation of Withania somnifera (L.) Dunal root extract in healthy human volunteers: A non-randomized, single dose study utilizing UHPLC-MS/MS analysis

Vaidya, V. G., Naik, N., Ganu, G. P., Parmar, V., Jagtap, S., Saste, G., Bhatt, A., Mulay, V. P., Girme, A., Modi, S. J., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117603 · Cited by 43 · see citing works

Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts

Wadhwa, R., Konar, A., & Kaul, S. C. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.09.001 · Cited by 43 · see citing works

Phytomedicine

Srivastava, A., Srivastava, P., Pandey, A., Khanna, V., & Pant, A. B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814619-4.00025-2 · Cited by 43 · see citing works

Protection against cerebral infarction by Withaferin A involves inhibition of neuronal apoptosis, activation of PI3K/Akt signaling pathway, and reduced intimal hyperplasia via inhibition of VSMC migration and matrix metalloproteinases

Zhang, Q., GUO, Y.-D., Li, H.-M., Wang, R.-Z., Guo, S., & Du, Y. (2017) · Advances in Medical Sciences · doi:10.1016/j.advms.2016.09.003 · Cited by 42 · see citing works

Efficacy of Natural Compounds in Neurodegenerative Disorders

Srivastava, P., & Yadav, R. S. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_7 · Cited by 41 · see citing works

Clinical safety and tolerability evaluation of Withania somnifera (L.) Dunal (Ashwagandha) root extract in healthy human volunteers

Vaidya, V. G., Gothwad, A., Ganu, G. P., Girme, A., Modi, S. J., & Hingorani, L. (2023) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2023.100859 · Cited by 40 · see citing works

Plant-Derived Natural Products for Parkinson’s Disease Therapy

Sengupta, T. K., Vinayagam, J., Singh, R. P., Jaisankar, P., & Mohanakumar, K. P. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_23 · Cited by 39 · see citing works

Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry

Dcruz, M. M., & Andrade, C. (2022) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2022.2121699 · Cited by 38 · see citing works

Aqueous Leaf Extract of Withania somnifera as a Potential Neuroprotective Agent in Sleep-deprived Rats: a Mechanistic Study

Manchanda, S., Mishra, R., Singh, R., Kaur, T., & Kaur, G. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9883-5 · Cited by 38 · see citing works

A Review on Pharmacological Profile of Withania somnifera (Ashwagandha).

Kaur, N., Niazi, J., & Raman, B. (2013) · HAL · Cited by 38 · see citing works

Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment

Ahmed, M. E., Javed, H., Khan, M. M., Vaibhav, K., Ahmad, A., Khan, A., Tabassum, R., Islam, F., Safhi, M. M., & Islam, F. (2013) · PROTOPLASMA · doi:10.1007/s00709-013-0482-2 · Cited by 37 · see citing works

Withania somnifera - a magic plant targeting multiple pathways in cancer related inflammation

Kumar, P., Sharma, R., & Garg, N. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154137 · Cited by 37 · see citing works

Mucuna pruriens seeds in treatment of Parkinson’s disease: pharmacological review

Kasture, S. B., Mohan, M., & Kasture, V. S. (2013) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-013-0126-2 · Cited by 36 · see citing works

Alcoholic Extract of Bacopa monniera Linn. Protects Against 6-Hydroxydopamine-Induced Changes in Behavioral and Biochemical Aspects: A Pilot Study

Shobana, C., Kumar, R. R., & Sumathi, T. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9833-3 · Cited by 35 · see citing works

Neuroprotective activity of Stereospermum suaveolens DC against 6-OHDA induced Parkinson′s disease model

Chandrashekhar, V. M., Shalavadi, M. H., Avinash, S., Sowmya, C. S., & Ramkishan, A. (2012) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.103275 · Cited by 34 · see citing works

Evaluation of toxicological and antioxidant potential of Nardostachys jatamansi in reversing haloperidol-induced catalepsy in rats

Ibrahim, M. O. (2010) · International Journal of General Medicine · doi:10.2147/ijgm.s9156 · Cited by 33 · see citing works

Complete Comparison Display (CCD) evaluation of ethanol extracts of Centella asiatica and Withania somnifera shows that they can non-synergistically ameliorate biochemical and behavioural damages in MPTP induced Parkinson's model of mice

Bhatnagar, M., Goel, I., Roy, T., Shukla, S. D., & Khurana, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177254 · Cited by 32 · see citing works

Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson’s Disease: Drug Effects of Withania somnifera (Dunal) Administration

Rose, F. D., Marotta, R., Poddighe, S., Talani, G., Catelani, T., Setzu, M. D., Solla, P., Marrosu, F., Sanna, E., Kasture, S. B., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146140 · Cited by 31 · see citing works

An Extract of Withania somnifera Attenuates Endothelin‐1‐stimulated Pigmentation in Human Epidermal Equivalents through the Interruption of PKC Activity Within Melanocytes

Nakajima, H., Wakabayashi, Y., Wakamatsu, K., & Imokawa, G. (2011) · Phytotherapy Research · doi:10.1002/ptr.3552 · Cited by 30 · see citing works

Effect and Mechanism of Chinese Herbal Medicine on Parkinson's Disease

Zeng, B. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.02.004 · Cited by 29 · see citing works

Neuropharmacological Properties of Withania somnifera - Indian Ginseng: An Overview on Experimental Evidence with Emphasis on Clinical Trials and Patents

Yenisetti, S. C., Manjunath, M. J., & ., M. (2016) · Recent Patents on CNS Drug Discovery · doi:10.2174/1574889810666160615014106 · Cited by 29 · see citing works

Withanolides against TLR4‐Activated Innate Inflammatory Signalling Pathways: A Comparative Computational and Experimental Study

Purushotham, P. M., Kim, J., Jo, E., & Senthil, K. (2016) · Phytotherapy Research · doi:10.1002/ptr.5746 · Cited by 29 · see citing works

Piriformospora indica elicitation of withaferin A biosynthesis and biomass accumulation in cell suspension cultures of Withania somnifera

Ahlawat, S., Saxena, P., Ali, A., & Abdin, M. Z. (2015) · Symbiosis · doi:10.1007/s13199-015-0364-9 · Cited by 28 · see citing works

Protective effects of ethanolic extract of Delphinium denudatum in a rat model of Parkinson's disease

Ahmad, M., Yousuf, S., Khan, M. B., Ahmad, A. S., Saleem, S., Hoda, M. N., & Islam, F. (2006) · Human & Experimental Toxicology · doi:10.1191/0960327106ht635oa · Cited by 28 · see citing works

Natural antioxidants in the management of Parkinson’s disease: Review of evidence from cell line and animal models

Abdul-Latif, R., Stupans, I., Allahham, A., Adhikari, B., & Thrimawithana, T. R. (2021) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2021.03.007 · Cited by 27 · see citing works

Organic Farming Practice for Quality Improvement of Tea and Its Anti Parkinsonism Effect on Health Defense

Bagchi, A. (2015) · Journal of Physical Chemistry & Biophysics · doi:10.4172/2161-0398.1000178 · Cited by 27 · see citing works

Neuroprotective effects of Withania somnifera in the SH-SY5Y Parkinson cell model

Wongtrakul, J., Thongtan, T., Kumrapich, B., Saisawang, C., & Ketterman, A. J. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08172 · Cited by 52 · see citing works

Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism

Prakash, J., Yadav, S. K., Chouhan, S., & Singh, S. P. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1005-4 · Cited by 128 · see citing works

Behavioral and biochemical observations on the neuroprotective impact of Withania somnifera extract in a rat model of Parkinson’s disease

Padole, V. S., Lobo, R. O., Nangude, M. S., Balde, G. H., Pal, R., Renuka Jyothi, S., Paricharak, S. P., & William, N. R. (2025) · JOURNAL OF EXPERIMENTAL ZOOLOGY INDIA · doi:10.51470/jez.2026.29.1.771

Withania somnifera Alleviates Parkinsonian Phenotypes by Inhibiting Apoptotic Pathways in Dopaminergic Neurons

Prakash, J., Chouhan, S., Yadav, S. K., Westfall, S., Nand, S., & Singh, S. P. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1443-7 · Cited by 211 · see citing works

Protective effects of ethanolic extract of Delphinium denudatum in a rat model of Parkinson's disease

Ahmad, M., Yousuf, S., Khan, M. B., Ahmad, A. S., Saleem, S., Hoda, M. N., & Islam, F. (2006) · Human & Experimental Toxicology · doi:10.1191/0960327106ht635oa · Cited by 28 · see citing works