Withania somnifera: an Indian ginseng
Abstract
Withania somnifera, popularly known as Ashwagandha is widely considered as the Indian ginseng. In Ayurveda, it is classified as a rasayana (rejuvenation) and expected to promote physical and mental health, rejuvenate the body in debilitated conditions and increase longevity. Having wide range of activity, it is used to treat almost all disorders that affect the human health. The present review discusses the pharmacological basis of the use of W. somnifera in various central nervous system (CNS) disorders, particularly its indication in epilepsy, stress and neurodegenerative diseases such as Parkinson's and Alzheimer's disorders, tardive dyskinesia, cerebral ischemia, and even in the management of drug addiction.
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Withanolide A can reconstruct neuronal networks.
“Withanolide A can reconstruct neuronal networks as well [166].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
Hydromethanolic root extracts inhibit lipid peroxidation in male Swiss Albino mice.
“| Hydromethanolic root extracts | Potent anti-oxidant | Male Swiss Albino mice | Increase in CAT, SOD, GSH, and GST | [166,286, |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
Hydromethanolic root extracts are potent anti-oxidants in male Swiss Albino mice.
“| Hydromethanolic root extracts | Potent anti-oxidant | Male Swiss Albino mice | Increase in CAT, SOD, GSH, and GST | [166,286, |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
Methanol extract regenerates neurites in SH-SY5Y cells.
“| Methanol extract | Revitalize nerve cells | SH-SY5Y cells | Regenerates neurites and reconstruct synapses | [166] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
Methanol extract reconstructs synapses in SH-SY5Y cells.
“| Methanol extract | Revitalize nerve cells | SH-SY5Y cells | Regenerates neurites and reconstruct synapses | [166] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
Methanol extract revitalizes nerve cells in SH-SY5Y cells.
“| Methanol extract | Revitalize nerve cells | SH-SY5Y cells | Regenerates neurites and reconstruct synapses | [166] |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
Hydromethanolic root extracts increase SOD in male Swiss Albino mice.
“| Hydromethanolic root extracts | Potent anti-oxidant | Male Swiss Albino mice | Increase in CAT, SOD, GSH, and GST | [166,286, |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
Hydromethanolic root extracts increase CAT in male Swiss Albino mice.
“| Hydromethanolic root extracts | Potent anti-oxidant | Male Swiss Albino mice | Increase in CAT, SOD, GSH, and GST | [166,286, |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
Hydromethanolic root extracts increase GST in male Swiss Albino mice.
“| Hydromethanolic root extracts | Potent anti-oxidant | Male Swiss Albino mice | Increase in CAT, SOD, GSH, and GST | [166,286, |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
Hydromethanolic root extracts increase GSH in male Swiss Albino mice.
“| Hydromethanolic root extracts | Potent anti-oxidant | Male Swiss Albino mice | Increase in CAT, SOD, GSH, and GST | [166,286, |”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [166]
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- Authors
- Kulkarni, S. K., & Dhir, A.
- Affiliations
- Panjab University (IN)
- Corresponding author
- Kulkarni, S.K.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 32
- Issue
- 5
- Pages
- 1093-1105
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2037441124
- Cited by
- 416
- References
- 72
- Citations by year
- 2026: 20 · 2025: 22 · 2024: 38 · 2023: 30 · 2022: 32 · 2021: 33 · 2020: 29 · 2019: 22 · 2018: 13 · 2017: 36 · 2016: 27 · 2015: 20 · 2014: 22 · 2013: 21 · 2012: 18
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- Withania somnifera, Ayurveda, Rasayana, central nervous system disorders, epilepsy, stress, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, tardive dyskinesia, cerebral ischemia, drug addiction, pharmacological activity
- MeSH terms
- Animals, Central Nervous System Diseases, Humans, Phytotherapy, Plant Preparations, Withania
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