The value of plasma neurotensin and cytokine measurement for the detection of bowel ischaemia in clinically doubtful cases: A prospective study
Abstract
The aim of this prospective study was to examine whether serum neurotensin, interleukin (IL)-6, and IL-8 are early predictor of bowel ischaemia especially in clinically equivocal cases. To this end, 56 patients were assigned to the following groups according to their disease: bowel ischaemia (group 1: n = 14), small bowel obstruction (group 2: n = 12), acute inflammation (group 3: n = 6), perforation (group 4: n = 8), and colorectal adenocarcinoma (group 5: n = 16). Fifteen healthy controls were assigned to group 6. Blood samples were obtained at enrollment, all measurements were done blindly, and all patients underwent surgery. Pretreatment doubtful diagnosis comprised of ileus, mild abdominal pain, and indeterminate imaging. Blood urea nitrogen, lactic acidosis, diagnostic workup, and IL-6 were predictors of diagnosis in univariate analysis. In multivariate analysis, IL-6 ( P < 0.001) and diagnostic workup ( P < 0.01) were independent predictors of the definite diagnosis. Neurotensin and IL-8 did not differentiate among groups. Considering clinically doubtful cases, IL-6 perfectly differentiates mesenteric ischaemia (of infarction/embolic/occlusive aetiology) from the rest of the indeterminate pathologies. The optimum cut-off point for IL-6 was 27.66 pg/mL. The value of serum IL-6 (27.66 pg/mL) had sensitivity = 1 and specificity = 1. In conclusion, plasma IL-6 measurement on admission might be an additional diagnostic tool that can predict bowel ischaemia in doubtful clinical situations.
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Serum IL-8 had sensitivity 88% and specificity 100% in a single study.
“Serum IL-8 (88 and 100%) [71].”
From Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis (2023) · cites this paper as [71]
Inflammatory biomarkers may not be able to distinguish between severe inflammation in the bowel or peritoneal cavity of other causes and mesenteric ischaemia.
“At the same time, inflammatory biomarkers may not be able to distinguish between severe inflammation in the bowel/peritoneal cavity of other causes vs. mesenteric ischaemia [71].”
From Diagnostic accuracy of biomarkers to detect acute mesenteric ischaemia in adult patients: a systematic review and meta-analysis (2023) · cites this paper as [71]
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- Authors
- Sgourakis, G., Papapanagiotou, A., Kontovounisios, C., Karamouzis, M. V., Lanitis, S., Konstantinou, C., Karaliotas, C., & Papavassiliou, A. G.
- Affiliations
- Hellenic Red Cross (GR)
- Department of Biological Chemistry, University of Athens Medical School, 11527 Athens, Greece
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Papavassiliou, Athanasios G
- ORCID
- Venue
- Experimental Biology and Medicine
- Publisher
- Frontiers Media SA
- Published
- 2013-07-04
- Volume
- 238
- Issue
- 8
- Pages
- 874-880
- ISSN
- 0071-3384 (ISSN-L)
- 1535-3702
- 1535-3699
- OpenAlex
- W2075789642
- Cited by
- 14
- References
- 17
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National and Kapodistrian University of Athens
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Keywords
- intestinal ischemia, mesenteric ischemia, interleukin-6, interleukin-8, neurotensin, plasma cytokines, small bowel obstruction, colorectal adenocarcinoma, perforation, diagnostic biomarkers, early diagnosis, lactic acidosis
- MeSH terms
- Adenocarcinoma, Adult, Aged, Aged, 80 and over, Diagnosis, Differential, Female, Humans, Intestinal Obstruction, Intestine, Small, Ischemia, Male, Middle Aged, Neurotensin, Prospective Studies, Colorectal Neoplasms, Biomarkers, Interleukin-6, Case-Control Studies, Interleukin-8
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