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Cited by 129Chemotherapy-induced organ toxicity mitigationChemotherapy-induced cardiotoxicity and mitigationChemotherapy-related skin toxicity

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

d -limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats

Rehman, Muneeb U, Tahir, Mir, Khan, Abdul Quaiyoom, Khan, Rehan, Oday-O-Hamiza, Lateef, Abdul, Hassan, Syed Kazim, Rashid, Sumaya, Ali, Nemat, Zeeshan, Mirza, Sultana, Sarwat·2014·Experimental Biology and Medicine
DOI 10.1177/1535370213520112
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Abstract

D-limonene is a naturally occurring monoterpene and has been found to posses numerous therapeutic properties. In this study, we used D-limonene as a protective agent against the nephrotoxic effects of anticancer drug doxorubicin (Dox). Rats were given D-limonene at doses of 5% and 10% mixed with diet for 20 consecutive days. Dox was give at the dose of 20 mg/kg body weight intraperitoneally. The protective effects of D-limonene on Dox-induced oxidative stress and inflammation were investigated by assaying oxidative stress biomarkers, lipid peroxidation, serum toxicity markers, proinflammatory cytokines, and expression of nuclear factor kappa B (NFκB), cyclo-oxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) and Nitrite levels. Administration of Dox (20 mg/kg body weight) in rats enhanced renal lipid peroxidation; depleted glutathione content and anti-oxidant enzymes; elevated levels of kidney toxicity markers viz. kidney injury molecule-1 (KIM-1), blood urea nitrogen (BUN), and creatinine; enhanced expression of NFκB, COX-2, and iNOS and nitric oxide. Treatment with D-limonene prevented oxidative stress by restoring the levels of antioxidant enzymes, further both doses of 5% and 10% showed significant decrease in inflammatory response. Both the doses of D-limonene significantly decreased the levels of kidney toxicity markers KIM-1, BUN, and creatinine. D-limonene also effectively decreased the Dox induced overexpression of NF-κB, COX-2, and iNOS and nitric oxide. Data from the present study indicate the protective role of D-limonene against Dox-induced renal damage.

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Crossref · 10.1177/1535370213520112

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Research works printed but not linked: 9

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Metadata

Authors
Rehman, M. U., Tahir, M., Khan, A. Q., Khan, R., Oday-O-Hamiza, Lateef, A., Hassan, S. K., Rashid, S., Ali, N., Zeeshan, M., & Sultana, S.
Affiliations
  • Jamia Hamdard (IN)
  • Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India
ORCID
Venue
Experimental Biology and Medicine
Publisher
Frontiers Media SA
Published
2014-02-28
Volume
239
Issue
4
Pages
465-476
ISSN
  • 0071-3384 (ISSN-L)
  • 1535-3702
  • 1535-3699
DOI
10.1177/1535370213520112
OpenAlex
W2327491744
Cited by
128
References
58
Citations by year
2026: 5 · 2025: 9 · 2024: 12 · 2023: 12 · 2022: 14 · 2021: 16 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 9 · 2016: 4 · 2015: 6 · 2014: 2
FWCI
5.20
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Experimental Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Chemotherapy-induced organ toxicity mitigation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
  • Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
Keywords
D-limonene, doxorubicin, nephrotoxicity, oxidative stress, inflammation, cyclooxygenase-2, inducible nitric oxide synthase, NF-κB, nitric oxide, lipid peroxidation, antioxidant enzymes, glutathione, KIM-1, inflammatory cytokines, renal protection, monoterpenes
MeSH terms
Limonene, Animals, Antioxidants, Doxorubicin, Glutathione, Kidney, Nitrites, Terpenes, Lipid Peroxidation, Biomarkers, Cytokines, NF-kappa B, Rats, Wistar, Oxidative Stress, Protective Agents, Rats, Cyclooxygenase 2, Nitric Oxide Synthase Type II, Cyclohexenes

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