Cited by 129Chemotherapy-induced organ toxicity mitigationChemotherapy-induced cardiotoxicity and mitigationChemotherapy-related skin toxicity

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

d -limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats

Rehman, Muneeb U, Tahir, Mir, Khan, Abdul Quaiyoom, Khan, Rehan, Oday-O-Hamiza, Lateef, Abdul, Hassan, Syed Kazim, Rashid, Sumaya, Ali, Nemat, Zeeshan, Mirza, Sultana, Sarwat·2014·Experimental Biology and Medicine

DOI 10.1177/1535370213520112

Open this paper in CoChat — free account

Abstract

D-limonene is a naturally occurring monoterpene and has been found to posses numerous therapeutic properties. In this study, we used D-limonene as a protective agent against the nephrotoxic effects of anticancer drug doxorubicin (Dox). Rats were given D-limonene at doses of 5% and 10% mixed with diet for 20 consecutive days. Dox was give at the dose of 20 mg/kg body weight intraperitoneally. The protective effects of D-limonene on Dox-induced oxidative stress and inflammation were investigated by assaying oxidative stress biomarkers, lipid peroxidation, serum toxicity markers, proinflammatory cytokines, and expression of nuclear factor kappa B (NFκB), cyclo-oxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) and Nitrite levels. Administration of Dox (20 mg/kg body weight) in rats enhanced renal lipid peroxidation; depleted glutathione content and anti-oxidant enzymes; elevated levels of kidney toxicity markers viz. kidney injury molecule-1 (KIM-1), blood urea nitrogen (BUN), and creatinine; enhanced expression of NFκB, COX-2, and iNOS and nitric oxide. Treatment with D-limonene prevented oxidative stress by restoring the levels of antioxidant enzymes, further both doses of 5% and 10% showed significant decrease in inflammatory response. Both the doses of D-limonene significantly decreased the levels of kidney toxicity markers KIM-1, BUN, and creatinine. D-limonene also effectively decreased the Dox induced overexpression of NF-κB, COX-2, and iNOS and nitric oxide. Data from the present study indicate the protective role of D-limonene against Dox-induced renal damage.

Integrity signals

Registry

Crossref · 10.1177/1535370213520112

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Glutathione S-Transferases
Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42083-8 · Cited by 18,509
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061
Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382
Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite
Jollow, D. J., Mitchell, J. R., ZAMPAGLIONE, N. G., & Gillette, J. R. (2008) · Pharmacology · doi:10.1159/000136485 · Cited by 3,291
Purification and characterization of the flavoenzyme glutathione reductase from rat liver.
Carlberg, I., & Mannervik, B. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41206-4 · Cited by 2,024
CRC handbook of methods for oxygen radical research
Bogomolets, B. B. (1985) · Experimental Gerontology · doi:10.1016/0531-5565(85)90021-x · Cited by 1,551
Interleukin‐10: new perspectives on an old cytokine
Mosser, D. M., & Zhang, X. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00706.x · Cited by 1,077
Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.
Benson, A. M., Hunkeler, M. J., & Talalay, P. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5216 · Cited by 750
Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney
Mohandas, J., Marshall, J. J., Duggin, G. G., HORVATH, J. S., & TILLER, D. J. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90353-8 · Cited by 738
The Regulation of Rat Liver Xanthine Oxidase
Stirpe, F., Corte, E. D., & Lorenzoni, E. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36428-1 · Cited by 733
The immune system and cardiac repair
Frangogiannis, N. G. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.007 · Cited by 667
[67] Lactic dehydrogenase of muscle
Kornberg, A. (1955) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(55)01072-0 · Cited by 664
Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer.
Mohandas, J., Marshall, J. J., Duggin, G. G., HORVATH, J. S., & TILLER, D. J. (1984) · PubMed · Cited by 543
Untitled work
(2007) · PubMed · Cited by 500
Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages—Induction by multiple nonphagocytic stimuli
Pick, E., & Keisari, Y. (1981) · Cellular Immunology · doi:10.1016/0008-8749(81)90411-1 · Cited by 488
Cytosolic factors which affect microsomal lipid peroxidation in lung and liver
Wright, J. R., Colby, H. D., & Miles, P. R. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90095-3 · Cited by 471
Adriamycin-induced heart failure: mechanisms and modulation
Singal, P. K., Li, T., Kumar, D., Danelisen, I., & Iliskovic, N. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007094214460 · Cited by 434
NF‐κB and virus infection: who controls whom
SANTORO, M. G., Rossi, A., & Amici, C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg267 · Cited by 401
Collateral Damage in Cancer Chemotherapy: Oxidative Stress in Nontargeted Tissues
Chen, Y., Jungsuwadee, P., Vore, M. E., Butterfield, D. A., & Clair, D. K. S. (2007) · Molecular Interventions · doi:10.1124/mi.7.3.6 · Cited by 388
Oxidative Damage of Cardiomyocytes Is Limited by Extracellular Regulated Kinases 1/2-mediated Induction of Cyclooxygenase-2
Adderley, S. R., & Fitzgerald, D. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.5038 · Cited by 375
Comparison of Kidney Injury Molecule-1 and Other Nephrotoxicity Biomarkers in Urine and Kidney Following Acute Exposure to Gentamicin, Mercury, and Chromium
Zhou, Y., Vaidya, V. S., Brown, R. P., Zhang, J., Rosenzweig, B. A., Thompson, K. L., Miller, T. J., Bonventre, J. V., & Goering, P. L. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm260 · Cited by 296
β-Amyloid Stimulation of Inducible Nitric-oxide Synthase in Astrocytes Is Interleukin-1β- and Tumor Necrosis Factor-α (TNFα)-dependent, and Involves a TNFα Receptor-associated Factor- and NFκB-inducing Kinase-dependent Signaling Mechanism
Akama, K. T., & Van Eldik, L. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7918 · Cited by 287
Potent Metalloporphyrin Peroxynitrite Decomposition Catalyst Protects Against the Development of Doxorubicin-Induced Cardiac Dysfunction
Pacher, P., Liaudet, L., Bai, P., Mabley, J. G., Kaminski, P. M., Virág, L., Deb, A., Szabó, É., Ungvari, Z. I., Wolin, M. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000048192.52098.dd · Cited by 279
Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity
Yılmaz, S., Ateşşahín, A., Şahna, E., Karahan, İ., & Ozer, S. (2005) · Toxicology · doi:10.1016/j.tox.2005.10.015 · Cited by 268
The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats
Saad, S. Y., Najjar, T. A. O., & Al‐Rikabi, A. C. (2001) · Pharmacological Research · doi:10.1006/phrs.2000.0769 · Cited by 265
Phase I and pharmacokinetic study of d -limonene in patients with advanced cancer
Vigushin, D. M., Poon, G. K., Boddy, A. V., English, J., Halbert, G., Pagonis, C., Jarman, M., & Coombes, R. C. (1998) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050793 · Cited by 251
Safety Evaluation And Risk Assessment Of d -Limonene
Kim, Y. W., Kim, M. J., Chung, B. Y., Bang, D. Y., Lim, S. K., Choi, S. M., Lim, D. S., Cho, M. C., Yoon, K., Kim, H. S., et al. (2013) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2013.769418 · Cited by 221
Doxorubicin and mechanical performance of cardiac trabeculae after acute and chronic treatment: a review
de Beer, E. L., Bottone, A. E., & Voest, E. E. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00765-8 · Cited by 185
Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFκB, TNF-α and caspase-3 expression in wistar rats
Arjumand, W., Seth, A., & Sultana, S. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.05.012 · Cited by 178
Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver
Patel, N., Joseph, C. K., Corcoran, G. B., & Ray, S. D. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.02.002 · Cited by 171
2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: Implications for the reactive oxygen species-mediated mechanisms of chemobrain
Aluise, C. D., Miriyala, S., Noel, T. J., Rukhsana Sultana, A., Jungsuwadee, P., Taylor, T. J., Cai, J., Pierce, W. M. J., Vore, M. E., Moscow, J. A., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.009 · Cited by 161
Alleviation of doxorubicin-induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats
Rashid, S., Ali, N., Nafees, S., Ahmad, S. T., Arjumand, W., Hasan, S. K., & Sultana, S. (2012) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2012.759306 · Cited by 158
The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis
Ghosh, J., Das, J., Manna, P., & Sil, P. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.048 · Cited by 155
Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation.
Handa, K., & Sato, S. (1975) · PubMed · Cited by 153
Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron (III) complex
Gutteridge, J. M. C. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90340-x · Cited by 133
Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats
Mohan, M., Kamble, S. M., Gadhi, P., & Kasture, S. B. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.10.042 · Cited by 126
Effects of caffeic acid phenethyl ester and alpha‐tocopherol on reperfusion injury in rat brain
Irmak, M. K., Fadıllıoğlu, E., Söğüt, S., Erdoğan, H., Güleç, M., Ozer, M., Yağmurca, M., & Gözükara, M. E. (2003) · Cell Biochemistry and Function · doi:10.1002/cbf.1024 · Cited by 123
Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: Plausible role of NF-κB
Rehman, M. U., Tahir, M., Khan, A. Q., Khan, R., Lateef, A., Oday-O-Hamiza, Qamar, W., Ali, F., & Sultana, S. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.11.013 · Cited by 123
Human metabolism of the experimental cancer therapeutic agent d-limonene
Crowell, P. L., Elson, C. E., Bailey, H. H., Elegbede, A., Haag, J. D., & Gould, M. N. (1994) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00686281 · Cited by 115
Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C60(OH)24 via suppression of oxidative stress.
Injac, R., Bošković, M., Perše, M., Furlan, E. K., Cerar, A., Djordjevic, A. N., & Štrukelj, B. (2008) · PubMed · Cited by 110
Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity
Ajith, T. A., Aswathy, M. S., & Hema, U. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.07.004 · Cited by 103
Epicatechin attenuates doxorubicin-induced brain toxicity: Critical role of TNF-α, iNOS and NF-κB
Mohamed, R. H., Karam, R. A., & Amer, M. G. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.07.001 · Cited by 97
Increased Plasma Endothelin-1 and Cardiac Nitric Oxide during Doxorubicin-Induced Cardiomyopathy
Sayed‐Ahmed, M. M., Khattab, M. M., Gad, M. Z., & Osman, A. M. (2001) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2001.d01-148.x · Cited by 91
Antioxidant potential of aroma compounds obtained by limonene biotransformation of orange essential oil
Maróstica, M. R., Silva, T. A. A. D. R. E., Franchi, G. C., Nowill, A. E., Pastore, G. M., & Hyslop, S. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.01.084 · Cited by 74
Ceramide Reduction and Transcriptional Up-Regulation of Glucosylceramide Synthase through Doxorubicin-Activated Sp1 in Drug-Resistant HL-60/ADR Cells
Uchida, Y., Itoh, M., Taguchi, Y., Yamaoka, S., Umehara, H., Ichikawa, S., Hirabayashi, Y., Holleran, W. M., & Okazaki, T. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1476 · Cited by 73
Resveratrol attenuates doxorubicin-induced cellular damage by modulating nitric oxide and apoptosis
Öktem, G., Uysal, A., Oral, O., Sezer, E., Olukman, M., Erol, A., Akgür, S. A., & Bılır, A. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.11.001 · Cited by 72
Effects of erdosteine treatment against doxorubicin-induced toxicity through erythrocyte and plasma oxidant/antioxidant status in rats
Fadıllıoğlu, E. (2003) · Pharmacological Research · doi:10.1016/s1043-6618(03)00010-0 · Cited by 69
Melatonin protects against myocardial doxorubicin toxicity in rats: role of physiological concentrations
Şahna, E., Parlakpınar, H., Özer, M. K., Öztürk, F., Özuğurlu, F., & Acet, A. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00084.x · Cited by 65
Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC–MS and chemometric resolution methods
Zhao, C., Zeng, Y., Wan, M.-Z., Li, R., Liang, Y., Li, C., Zeng, Z., & Chau, F. (2009) · Journal of Separation Science · doi:10.1002/jssc.200800484 · Cited by 56
Diet, Natural Products and Cancer Chemoprevention
Singletary, K. W. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.465s · Cited by 42
Efficiency of propolis extract against mitochondrial stress induced by antineoplasic agents (doxorubicin and vinblastin) in rats.
Benguedouar, L., Boussenane, H. N., Kebsa, W., Alyane, M., Rouibah, H., & Lahouel, M. (2008) · PubMed · Cited by 38
Basal and drug-induced antioxidant enzyme activities correlate with age-dependent doxorubicin oxidative toxicity
Pritsos, C. A., & Ma, J. (2000) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00159-9 · Cited by 33
Influence of a low-molecular-weight heparin derivative on the nitric oxide levels and apoptotic DNA damage in adriamycin-induced cardiac and renal toxicity
Deepa, P. R., & Varalakshmi, P. (2005) · Toxicology · doi:10.1016/j.tox.2005.09.009 · Cited by 28
Protection of doxorubicin-induced DNA damage by sodium selenite and selenomethionine in Wistar rats
dos Santos, R. A., Jordão, A. A., Vannucchi, H., & Takahashi, C. S. (2007) · Nutrition Research · doi:10.1016/j.nutres.2007.04.007 · Cited by 21
Differential induction and activation of NF‐κB transcription complexes in radiation‐induced chromosomally unstable cell lines
Snyder, A. R., & Morgan, W. F. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20092 · Cited by 18
Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
Antunes, L. M. G., & Takahashi, C. S. (1999) · Genetics and Molecular Biology · doi:10.1590/s1415-47571999000200015 · Cited by 16
Erlotinib Preserves Renal Function and Prevents Salt Retention in Doxorubicin Treated Nephrotic Rats
Matar, R. N. B., Klein, J. D., & Sands, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054738 · Cited by 16

Research works printed but not linked: 9

Handa K, 1975, Gann, 66, 43
10.1016/j.freeradbiomed.2011.03.009 · DOI
Antunes LMG, 1999, Genet Mol Biol, 2, 225
Benguedouar L, 2008, Ind J Exp Biol, 46, 112
Mohandas M, 1984, Cancer Res, 44, 5086
Injac R, 2008, Pharmacol Rep, 60, 742
Ogunbayode I, 2010, Afr J Pharma Sci Pharmacy, 1, 96
Irmak MK, 2003, Cell Biochem Funct, 26, 783
Sun J, 2007, Alt Med Rev, 12, 2007

Sorted by citations

Limonene: Aroma of innovation in health and disease
Vieira, A. J., Beserra, F. P., de Souza, M. C., Totti, B. M., & Rozza, A. L. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.02.007 · Cited by 388
D‐limonene: A multifunctional compound with potent therapeutic effects
Anandakumar, P., Kamaraj, S., & Vanitha, M. K. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13566 · Cited by 347
Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus
Nuutinen, T. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.07.076 · Cited by 285
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases
Kim, T., Song, B., Cho, K. S., & Lee, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062187 · Cited by 282
Terpenes from Forests and Human Health
Cho, K. S., Lim, Y., Lee, K., Lee, J., Lee, J. H., & Lee, I. (2017) · Toxicological Research · doi:10.5487/tr.2017.33.2.097 · Cited by 237

See all 129

Authors: Rehman, M. U., Tahir, M., Khan, A. Q., Khan, R., Oday-O-Hamiza, Lateef, A., Hassan, S. K., Rashid, S., Ali, N., Zeeshan, M., & Sultana, S.
Affiliations: Jamia Hamdard (IN)
Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India
ORCID: Rehman, Muneeb U
Khan, Rehan
Ali, Nemat
Sultana, Sarwat
Venue: Experimental Biology and Medicine
Publisher: Frontiers Media SA
Published: 2014-02-28
Volume: 239
Issue: 4
Pages: 465-476
ISSN: 0071-3384 (ISSN-L)
1535-3702
1535-3699
DOI: 10.1177/1535370213520112
OpenAlex: W2327491744
Cited by: 128
References: 58
Citations by year: 2026: 5 · 2025: 9 · 2024: 12 · 2023: 12 · 2022: 14 · 2021: 16 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 9 · 2016: 4 · 2015: 6 · 2014: 2
FWCI: 5.20
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Experimental Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Chemotherapy-induced organ toxicity mitigation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
Keywords: D-limonene, doxorubicin, nephrotoxicity, oxidative stress, inflammation, cyclooxygenase-2, inducible nitric oxide synthase, NF-κB, nitric oxide, lipid peroxidation, antioxidant enzymes, glutathione, KIM-1, inflammatory cytokines, renal protection, monoterpenes
MeSH terms: Limonene, Animals, Antioxidants, Doxorubicin, Glutathione, Kidney, Nitrites, Terpenes, Lipid Peroxidation, Biomarkers, Cytokines, NF-kappa B, Rats, Wistar, Oxidative Stress, Protective Agents, Rats, Cyclooxygenase 2, Nitric Oxide Synthase Type II, Cyclohexenes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

d -limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks