Cited by 129Chemotherapy-induced organ toxicity mitigationChemotherapy-induced cardiotoxicity and mitigationChemotherapy-related skin toxicity

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d -limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats

Rehman, Muneeb U, Tahir, Mir, Khan, Abdul Quaiyoom, Khan, Rehan, Oday-O-Hamiza, Lateef, Abdul, Hassan, Syed Kazim, Rashid, Sumaya, Ali, Nemat, Zeeshan, Mirza, Sultana, Sarwat·2014·Experimental Biology and Medicine

DOI 10.1177/1535370213520112

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Abstract

D-limonene is a naturally occurring monoterpene and has been found to posses numerous therapeutic properties. In this study, we used D-limonene as a protective agent against the nephrotoxic effects of anticancer drug doxorubicin (Dox). Rats were given D-limonene at doses of 5% and 10% mixed with diet for 20 consecutive days. Dox was give at the dose of 20 mg/kg body weight intraperitoneally. The protective effects of D-limonene on Dox-induced oxidative stress and inflammation were investigated by assaying oxidative stress biomarkers, lipid peroxidation, serum toxicity markers, proinflammatory cytokines, and expression of nuclear factor kappa B (NFκB), cyclo-oxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) and Nitrite levels. Administration of Dox (20 mg/kg body weight) in rats enhanced renal lipid peroxidation; depleted glutathione content and anti-oxidant enzymes; elevated levels of kidney toxicity markers viz. kidney injury molecule-1 (KIM-1), blood urea nitrogen (BUN), and creatinine; enhanced expression of NFκB, COX-2, and iNOS and nitric oxide. Treatment with D-limonene prevented oxidative stress by restoring the levels of antioxidant enzymes, further both doses of 5% and 10% showed significant decrease in inflammatory response. Both the doses of D-limonene significantly decreased the levels of kidney toxicity markers KIM-1, BUN, and creatinine. D-limonene also effectively decreased the Dox induced overexpression of NF-κB, COX-2, and iNOS and nitric oxide. Data from the present study indicate the protective role of D-limonene against Dox-induced renal damage.

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Authors: Rehman, M. U., Tahir, M., Khan, A. Q., Khan, R., Oday-O-Hamiza, Lateef, A., Hassan, S. K., Rashid, S., Ali, N., Zeeshan, M., & Sultana, S.
Affiliations: Jamia Hamdard (IN)
Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062, India
ORCID: Rehman, Muneeb U
Khan, Rehan
Ali, Nemat
Sultana, Sarwat
Venue: Experimental Biology and Medicine
Publisher: Frontiers Media SA
Published: 2014-02-28
Volume: 239
Issue: 4
Pages: 465-476
ISSN: 0071-3384 (ISSN-L)
1535-3702
1535-3699
DOI: 10.1177/1535370213520112
OpenAlex: W2327491744
Cited by: 128
References: 58
Citations by year: 2026: 5 · 2025: 9 · 2024: 12 · 2023: 12 · 2022: 14 · 2021: 16 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 9 · 2016: 4 · 2015: 6 · 2014: 2
FWCI: 5.20
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Experimental Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Chemotherapy-induced organ toxicity mitigation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Chemotherapy-induced cardiotoxicity and mitigation
Health Sciences › Medicine › Dermatology › Chemotherapy-related skin toxicity
Keywords: D-limonene, doxorubicin, nephrotoxicity, oxidative stress, inflammation, cyclooxygenase-2, inducible nitric oxide synthase, NF-κB, nitric oxide, lipid peroxidation, antioxidant enzymes, glutathione, KIM-1, inflammatory cytokines, renal protection, monoterpenes
MeSH terms: Limonene, Animals, Antioxidants, Doxorubicin, Glutathione, Kidney, Nitrites, Terpenes, Lipid Peroxidation, Biomarkers, Cytokines, NF-kappa B, Rats, Wistar, Oxidative Stress, Protective Agents, Rats, Cyclooxygenase 2, Nitric Oxide Synthase Type II, Cyclohexenes

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d -limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFκB in kidneys of Wistar rats

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